Case Report: Multifocal EBV-Associated Diffuse Large B-Cell Lymphoma in a Patient With 6-MP Associated Lymphopenia With TPMT Deficiency

Autor: Lara Müller-Scholden, Frank Deinlein, Matthias Eyrich, Paul Gerhardt Schlegel, Verena Wiegering, Matthias Wölfl

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

IntroductionEBV associated lymphoproliferative disorders (EBV LPD) are a known complication following solid organ or hematopoietic stem cell transplantation. The disturbance of the immune system leads to a lack of control of latent EBV-infected B-cel

Externí odkaz: https://doaj.org/article/505cc89bd335495b8b3e10fdd3299b75

Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial

Autor: Christian Hagel, Veronika Sloman, Martin Mynarek, Katharina Petrasch, Denise Obrecht, Joachim Kühl, Frank Deinlein, Renate Schmid, André O. von Bueren, Carsten Friedrich, B. Ole Juhnke, Nicolas U. Gerber, Robert Kwiecien, Hermann Girschick, Alexandra Höller, Antonia Zapf, Katja von Hoff, Stefan Rutkowski

Publikováno v: Hagel, C, Sloman, V, Mynarek, M, Petrasch, K, Obrecht, D, Kühl, J, Deinlein, F, Schmid, R, von Bueren, A O, Friedrich, C, Juhnke, B O, Gerber, N U, Kwiecien, R, Girschick, H, Höller, A, Zapf, A, von Hoff, K & Rutkowski, S 2022, ' Refining M1 stage in medulloblastoma : criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial ', European journal of cancer (Oxford, England : 1990), vol. 164, pp. 30-38 . https://doi.org/10.1016/j.ejca.2021.12.032

BACKGROUND: Medulloblastoma is the most common malignant paediatric brain tumour, and cerebrospinal fluid (CSF) dissemination (M1 stage) is a high-risk prognostic factor. Criteria for CSF evaluation and for differentiating M0 from M1 stage are not cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2606ca2650132764c9c0988e3fa4347
https://doi.org/10.1016/j.ejca.2021.12.032

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

Autor: Camelia M. Monoranu, Klaus Pietschmann, Denise Obrecht, Robert Kwiecien, Marcel Kool, Michael A. Grotzer, Stefan M. Pfister, Torsten Pietsch, Andreas Faldum, Martin Sill, Paul G. Schlegel, Gudrun Fleischhack, Martin Mynarek, Andreas von Deimling, Marina Ryzhova, Rolf-Dieter Kortmann, Markus J. Riemenschneider, Nicolas U. Gerber, Martin Benesch, Carsten Friedrich, Christian Hartmann, Irene Slavc, Natalie Jaeger, Hildegard Dohmen, Katja von Hoff, André O. von Bueren, Felix Sahm, Frank Deinlein, Andrey Korshunov, Christine Haberler, Christian Mawrin, Martin Hasselblatt, Wolfgang Brück, Ori Staszewski, Matthias Meinhardt, Andrey Golanov, Olga Zheludkova, Holger Ottensmeier, Stefan Rutkowski, Ulrich Schüller, Monika Warmuth-Metz, Arend Koch, Elisabeth J. Rushing, Jens Schittenhelm, Tanvi Sharma, Katharina Filipski, Brigitte Bison, Clemens Sommer, Björn-Ole Juhnke

Publikováno v: Journal of clinical oncology, Vol. 38, No 18 (2020) pp. 2028-2040
J Clin Oncol
Journal of clinical oncology 38(18), 2028-2040 (2020). doi:10.1200/JCO.19.03057

PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f778e16e49773fcc31183e526ac4be
https://archive-ouverte.unige.ch/unige:157305

PATH-07. QUALITY ASSURANCE IN CEREBROSPINAL FLUID CYTOLOGY ASSESSMENT FOR MEDULLOBLASTOMA STAGING LEADS TO POTENTIAL IMPROVED RISK-GROUP ASSESSMENT IN THE PROSPECTIVE MULTICENTER HIT-2000 TRIAL

Autor: Nicolas U. Gerber, Carsten Friedrich, Robert Kwiecien, Renate Schmid, Frank Deinlein, Alexandra Höller, Stefan Rutkowski, Katja von Hoff, Christian Hagel, Antonia Zapf, Hermann Girschick, Denise Obrecht, Veronika Sloman, André O. von Bueren, B Ole Juhnke, Martin Mynarek, Katharina Petrasch

Publikováno v: Neuro-Oncology

BACKGROUND Cerebrospinal fluid (CSF) dissemination of medulloblastoma (M1 stage) is a high-risk prognostic factor. However, because diagnostic criteria for M1 staging are missing we specified process-related and cytomorphological parameters influenci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afd5d8efb04d7ade9f2e6edf1136cf6
https://doi.org/10.1093/neuonc/noaa222.643

Treatment of adult nonmetastatic medulloblastoma patients according to the paediatric HIT 2000 protocol: A prospective observational multicentre study

Autor: Stefan Rutkowski, Rolf D. Kortmann, Torsten Pietsch, Monika Warmuth-Metz, Peter Hau, Robert Kwiecien, Frank Deinlein, André O. von Bueren, Joachim Kuehl, Carsten Friedrich, Katja von Hoff

Publikováno v: European Journal of Cancer. 49:893-903

Background Medulloblastoma in adulthood is rare. Knowledge is limited, and the efficacy and toxicity of chemotherapy--especially in nonmetastatic disease--is still elusive. Methods Seventy adults aged ≥21 years (median age: 28.5 years) with nonmeta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138efc9f8a0e9492e78a689c2a3ea5cc
https://doi.org/10.1016/j.ejca.2012.10.006