Výsledky vyhledávání - "Frank D. Mills"

Residue specific partitioning of KL4 into phospholipid bilayers

Autor: Gail E. Fanucci, Joanna R. Long, Austin L. Turner, Frank D. Mills, Otonye Braide

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1838(12):3212-3219

KL4, which has demonstrated success in the treatment of respiratory distress, is a synthetic helical, amphipathic peptide mimetic of lung surfactant protein B. The unusual periodicity of charged residues within KL4 and its relatively high hydrophobic

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Penetration Depth of Surfactant Peptide KL4 into Membranes Is Determined by Fatty Acid Saturation

Autor: Frank D. Mills, Vijay C. Antharam, Douglas W. Elliott, R. Suzanne Farver, Edward Sternin, Joanna R. Long

Publikováno v: Biophysical Journal. 96:4085-4098

KL(4) is a 21-residue functional peptide mimic of lung surfactant protein B, an essential protein for lowering surface tension in the alveoli. Its ability to modify lipid properties and restore lung compliance was investigated with circular dichroism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e9e17f189e6b89651af0c92d460ca6
https://doi.org/10.1016/j.bpj.2008.12.3966

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Interactions of the C-terminus of lung surfactant protein B with lipid bilayers are modulated by acyl chain saturation

Autor: Vijay C. Antharam, Katherine H. Sippel, R. Suzanne Farver, Douglas W. Elliott, Anna Kuznetsova, Joanna R. Long, Frank D. Mills, Edward Sternin

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778:2544-2554

Lung surfactant protein B (SP-B) is critical to minimizing surface tension in the alveoli. The C-terminus of SP-B, residues 59-80, has much of the surface activity of the full protein and serves as a template for the development of synthetic surfacta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5ab4f7edf5c5573a1e839550664c80
https://doi.org/10.1016/j.bbamem.2008.07.013

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The Helical Structure of Surfactant Peptide KL4 When Bound to POPC: POPG Lipid Vesicles

Autor: Frank D. Mills, Joanna R. Long, Vijay C. Antharam, Omjoy K. Ganesh, Doug W. Elliott, Seth A. McNeill

Publikováno v: Biochemistry. 47:8292-8300

KL 4 is a 21-residue peptide employed as a functional mimic of lung surfactant protein B, which successfully lowers surface tension in the alveoli. A mechanistic understanding of how KL 4 affects lipid properties has proven elusive as the secondary s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f8b4c9cd1be4888dc84373c4f04bd8
https://doi.org/10.1021/bi702551c

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A high resolution structure of the putative hinge region in M2 channel-lining segments of the nicotinic acetylcholine receptor

Autor: Frank Raucci, Joanna R. Long, Frank D. Mills

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768:2961-2970

Transmembrane peptide helices play key roles in signal transduction across cell membranes, yet little is known about their high-resolution structure or the role membrane composition plays in their association, structure, dynamics and ultimately their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ea7b2618d426c1356825df9c5b1c53
https://doi.org/10.1016/j.bbamem.2007.10.012

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ChemInform Abstract: One-Step Synthesis of Methyl Esters from Nitriles

Autor: Richard T. Brown, Frank D. Mills

Publikováno v: ChemInform. 22

Polyphosphate ester that contains methanol easily converts aromatic and alkyl nitriles in one step and in high yield to the corresponding methyl ester at 120° – 150°c.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b54817f63c6b3f21f9d620b243ac8cc
https://doi.org/10.1002/chin.199115134

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Determination of peptide backbone torsion angles using double-quantum dipolar recoupling solid-state NMR spectroscopy

Autor: Frank D. Mills, Seth A. McNeill, Matthew T. Eddy, M. A. Mehta, Joanna R. Long

Publikováno v: Journal of the American Chemical Society. 130(7)

Several approaches for utilizing dipolar recoupling solid-state NMR (ssNMR) techniques to determine local structure at high resolution in peptides and proteins have been developed. However, many of these techniques measure only one torsion angle or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba70d1a9e0f74fa54065a40cf83e6162
https://pubmed.ncbi.nlm.nih.gov/18220389

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One-Step Synthesis of Methyl Esters from Nitriles

Autor: Frank D. Mills, Richard T. Brown

Publikováno v: Synthetic Communications. 20:3131-3135

Polyphosphate ester that contains methanol easily converts aromatic and alkyl nitriles in one step and in high yield to the corresponding methyl ester at 120° – 150°c.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5278ddd1612a3ce3f1a892bd0e6a61eb
https://doi.org/10.1080/00397919008051536

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Preparation and catalytic hydrogenation of 4,6-dimethyl- and 4,7-dimethyl-8-methoxycoumarins. A 4-methyldihydrocoumarin synthesis

Autor: Frank D. Mills

Publikováno v: Journal of Heterocyclic Chemistry. 17:1597-1600

Reduction of the title coumarins at 1500 psi and 150° over 10% palladium on charcoal provides a simple route to dihydrocoumarins and/or ethyl butanoates, hydrogenolysis products of the lactone. Lower pressures and temperatures tend to yield only the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e0c892004364292586e3c016ada9ef
https://doi.org/10.1002/jhet.5570170749

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