Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Frank Chinga"'
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 861-871 (2016)
The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells
Externí odkaz:
https://doaj.org/article/6774ad7c2a1d49808063d722144b909a
Autor:
Frank Chinga, Serge Y. Fuchs, Zoya Ignatova, Jiangbin Ye, Crystal S. Conn, Weixuan Fu, Constantinos Koumenis, Andrew V. Kossenkov, Carlo Salas Salinas, Ioannis I. Verginadis, Nektaria Maria Leli, Ravi K. Amaravadi, Christine Polte, Paul P. Wang, Alexandra M Monroy, Davide Ruggero, J. Alan Diehl, Feven Tameire, Rani Ojha
Publikováno v:
Nature cell biology, vol 21, iss 7
Nature cell biology
Nature cell biology
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f738c982d153fa8258254dd5ce12da
https://doi.org/10.1038/s41556-019-0347-9
https://doi.org/10.1038/s41556-019-0347-9
Autor:
Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, J. Alan Diehl, Serge Y. Fuchs, Ellen Puré, Constantinos Koumenis
Publikováno v:
Nature cell biology. 24(6)
Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples cell growth and survival to bioenergetic demands. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374b585dbc21540d90e876209b13f267
https://pubmed.ncbi.nlm.nih.gov/35654838
https://pubmed.ncbi.nlm.nih.gov/35654838
Autor:
Ioannis I. Verginadis, Harris Avgousti, Kyle Kim, Giorgos Skoufos, Frank Chinga, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Artemis G. Hatzigeorgiou, Sandra Ryeom, Alan J. Diehl, Serge Y. Fuchs, Ellen Puré, Constantinos Koumenis
Publikováno v:
Cancer Research. 82:3178-3178
Despite recent advances in prevention and treatment, including immune checkpoint inhibitors, malignant melanoma remains a particularly aggressive and deadly malignancy, which is partly attributed to its highly heterogeneous TME. However, malignant ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c2225c668afbe96ccf2bf86d41ae259
https://doi.org/10.1158/1538-7445.am2022-3178
https://doi.org/10.1158/1538-7445.am2022-3178
Autor:
Ioannis Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Nektaria Maria Leli, Ilias Karagounis, Brett Bell, Carlo Salas Salinas, Yang Li, Jiangbin Ye, David Scott, Andrei Osterman, Arjun Sengupta, Aalim Weljie, Enrico Radaelli, John Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis Hatzigeorgiou, Sandra Ryeom, J Alan Diehl, Serge Fuchs, Ellen Pure', Constantinos Koumenis
ATF4 is a major effector of the Integrated Stress Response (ISR), a homeostatic mechanism coupling cell growth and survival to bioenergetic demands. Although the pro-tumorigenic role of the ISR in a tumor cell-intrinsic manner has been established, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce6f12c9365c81264086551773491cc
https://doi.org/10.21203/rs.3.rs-122088/v1
https://doi.org/10.21203/rs.3.rs-122088/v1
Autor:
Bo Young Nam, Jihwan Park, Tae Hyun Yoo, Jung Tak Park, Szu Yuan Li, Mei Yan Wu, Frank Chinga, Seung Hyeok Han, Shin Wook Kang, Katalin Susztak
Publikováno v:
Journal of the American Society of Nephrology. 28:3312-3322
Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in fibrosis development. The molecular mechanism of Notch-induced fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb776d4eb2d7a8e3bd6f19d333f9e6d
https://doi.org/10.1681/asn.2017020130
https://doi.org/10.1681/asn.2017020130
Autor:
Jianling Tao, Seung Hyeok Han, Katalin Susztak, Laura Malaga-Dieguez, Frank Chinga, Kimberly J. Reidy, Hyun Mi Kang
Publikováno v:
Journal of the American Society of Nephrology. 27:439-453
Renal tubule epithelial cells are high-energy demanding polarized epithelial cells. Liver kinase B1 (LKB1) is a key regulator of polarity, proliferation, and cell metabolism in epithelial cells, but the function of LKB1 in the kidney is unclear. Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ae07d687cf2f77c3367df725e68e04
https://doi.org/10.1681/asn.2014121181
https://doi.org/10.1681/asn.2014121181
Autor:
Katalin Susztak, Ira J. Goldberg, Seung Hyeok Han, Erwin P. Bottinger, Hyun Mi Kang, James Pullman, Yi-An Ko, Jianling Tao, Peter S. Choi, Seon Ho Ahn, Kumar Sharma, Ae Seo Deok Park, Frank Chinga
Publikováno v:
Nature Medicine. 21:37-46
Renal fibrosis is the histological manifestation of a progressive, usually irreversible process causing chronic and end-stage kidney disease. We performed genome-wide transcriptome studies of a large cohort (n = 95) of normal and fibrotic human kidne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c372aadd554b30de3d7f1077d9097930
https://doi.org/10.1038/nm.3762
https://doi.org/10.1038/nm.3762
Autor:
Nektaria Maria Leli, Frank Chinga, Christine Polte, Paul P. Wang, Davide Ruggero, Feven Tameire, Ioannis I. Verginadis, Alexandra M Monroy, Constantinos Koumenis, Crystal S. Conn, Weixuan Fu, Rani Ojha, J. Alan Diehl, Zoya Ignatova, Andrew V. Kossenkov, Serge Y. Fuchs, Jiangbin Ye, Ravi K. Amaravadi, Carlo Salas Salinas
Publikováno v:
Nature Cell Biology. 21:1052-1052
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a123b4967d78b305f68c31eb172892bd
https://doi.org/10.1038/s41556-019-0370-x
https://doi.org/10.1038/s41556-019-0370-x