Výsledky vyhledávání - "Frank C. Stomski"

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Autor: Suraiya A Onnesha, Frank C. Stomski, Mara Dottore, Denis Tvorogov, Angel F. Lopez, Johannes Foßelteder, David M. Ross, Andreas Reinisch, Chloe Al Thompson-Peach, Kelly Sy Lim, Daniel Thomas

Publikováno v: Blood. 138:3597-3597

Introduction: Mutations within the gene encoding calreticulin (CALR) are the second most common genetic aberration associated with primary myelofibrosis (PMF), observed in 70% of non-JAK2 V617F cases. Importantly, patients with CALR mutations do not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddbcf5885c4c0cd447e14b2839e9073a
https://doi.org/10.1182/blood-2021-154332

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Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Autor: Frank C. Stomski, Winnie L. Kan, Mara Dottore, Ravindra Majeti, Vinay Tergaonkar, Timothy P. Hughes, Jeffrey J. Babon, Denis Tvorogov, Daniel Thomas, Nicholas P. D. Liau, Angel F. Lopez, Maya Lathi, Timothy R. Hercus, Michael W. Parker, David M. Ross, Emma F Barry

Publikováno v: Science Advances

Pathological drug withdrawal syndrome is linked to accumulation of JAK2 phosphorylation in V617F myelofibrosis.
Treatment of patients with myelofibrosis with the type I JAK (Janus kinase) inhibitor ruxolitinib paradoxically induces JAK2 activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8125c8839c0723efed1e6f629ed18144
https://pubmed.ncbi.nlm.nih.gov/30498775

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Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Autor: Ravindra Majeti, Timothy P. Hughes, Nicholas P. D. Liau, Frank C. Stomski, David M. Ross, Winnie L. Kan, T.R. Hercus, Denis Tvorogov, Michael W. Parker, Vinay Tergaonkar, Jeffrey J. Babon, Angel F. Lopez, Daniel Thomas, Emma F Barry, Maya Lathi, Mara Dottore

Publikováno v: Blood. 132:1787-1787

Patients with myelofibrosis who are treated with the Type I ATP competitive JAK inhibitor ruxolitinib derive symptomatic benefit from improvement in cytokine-mediated symptoms, and show cytoreductive responses in disease manifestations, such as splen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76e8ea69ba4c21c3c02a2295cca09b66
https://doi.org/10.1182/blood-2018-99-115760

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The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Autor: William J. McKinstry, Michael W. Parker, Guido Hansen, Mark A. Guthridge, Frank C. Stomski, Jason A. Powell, Angel F. Lopez, Barbara J. McClure, Hayley S. Ramshaw, Joanna M. Woodcock, Mara Dottore, Yibin Xu, Timothy R. Hercus

Publikováno v: Cell. 134:496-507

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that controls the production and function of blood cells, is deregulated in clinical conditions such as rheumatoid arthritis and leukemia, yet offers therapeutic valu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3032121b1ceebf72ca2fed48bf54286
https://doi.org/10.1016/j.cell.2008.05.053

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The Dimeric Versus Monomeric Status of 14-3-3ζ Is Controlled by Phosphorylation of Ser58 at the Dimer Interface

Autor: Joanna M. Woodcock, Jane E. Murphy, Angel F. Lopez, Michael C. Berndt, Frank C. Stomski

Publikováno v: Journal of Biological Chemistry. 278:36323-36327

The 14-3-3 proteins play a central role in the regulation of cell growth, cycling, and apoptosis by modulating the functional activities of key signaling proteins. Through binding to a phosphoserine motif, 14-3-3 alters target proteins activities by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68173d41086602851103886777fc3c4e
https://doi.org/10.1074/jbc.m304689200

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Threonine 391 Phosphorylation of the Human Prolactin Receptor Mediates a Novel Interaction with 14-3-3 Proteins

Autor: Monilola A. Olayioye, Frank C. Stomski, Mark A. Guthridge, Angel F. Lopez, Geoffrey J. Lindeman, Jane E. Visvader

Publikováno v: Journal of Biological Chemistry. 278:32929-32935

The prolactin receptor (PrlR) is a member of the cytokine receptor superfamily that lacks an intrinsic kinase domain and relies on the cytoplasmic Jak tyrosine kinases to transduce signals. Prolactin-induced Jak2 activation and consequent tyrosine ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6f77700ed5932c65224eac85ce7569
https://doi.org/10.1074/jbc.m302910200

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Site-Specific Serine Phosphorylation of the IL-3 Receptor Is Required for Hemopoietic Cell Survival

Autor: Mara Dottore, Michael C. Berndt, Frank C. Stomski, Barbara J. McClure, Wendy R. Winnall, Angel F. Lopez, Joanna M. Woodcock, Mark A. Guthridge, Emma F Barry

Publikováno v: Molecular Cell. 6:99-108

In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a188298f1f4ab312d01a871cb1aebe
https://doi.org/10.1016/s1097-2765(05)00002-x

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The Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated by GM-CSF, Interleukin-3, or Interleukin-5

Autor: Barbara J. McClure, Frank C. Stomski, M J Elliott, Joanna M. Woodcock, Angel F. Lopez, Christopher J. Bagley

Publikováno v: Blood. 90:3005-3017

The granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor is expressed on normal and malignant hematopoietic cells as well as on cells from other organs in which it transduces a variety of functions. Despite the widespread expression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::657e45a7523c64eadf01610e06686c9e
https://doi.org/10.1182/blood.v90.8.3005

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The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors

Autor: Frank C. Stomski, Joanna M. Woodcock, Angel F. Lopez, Christopher J. Bagley

Publikováno v: Blood. 89:1471-1482

CYTOKINE RECEPTORS are cell-surface glycoproteins that bind specifically to cytokines and transduce their signals. These receptors enable cells to communicate with the extracellular environment by responding to signals generated in the vicinity or in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085ae267c9e685559527ead7f4501c8d
https://doi.org/10.1182/blood.v89.5.1471.1471_1471_1482

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