Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Frank C. Dorsey"'
Autor:
Luke A. Bourner, Linda A. Chung, Haiyan Long, Anne F. McGettrick, Junpeng Xiao, Kenneth Roth, Jade D. Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero, David C. Gemperline, Lin Zhang, Ying C. Wang, Michael J. Chalmers, Chiao-Wen Yang, Jesus A. Gutierrez, Luke A.J. O’Neill, Frank C. Dorsey
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114570- (2024)
Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to
Externí odkaz:
https://doaj.org/article/55ca952d3ac049d4a45d8028c026aed2
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Supplementary Figure Legends & Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057a178b991babc2517ecf5b994d7838
https://doi.org/10.1158/1078-0432.22471418.v1
https://doi.org/10.1158/1078-0432.22471418.v1
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Figure S1. Efficacy of pemetrexed in Lewis Lung carcinoma model and metabolomic analysis of MC38 tumor bearing mice treated with 50 mg/kg of pemetrexed Figure S2. T cell inflamed phenotype induced by pemetrexed is modestly reduced in tumors upon comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf5c80af2bf8dacf087ab7a6132752
https://doi.org/10.1158/1078-0432.22471421
https://doi.org/10.1158/1078-0432.22471421
Autor:
John L. Cleveland, Anders E. Berglund, John M. Koomen, Zhihua Chen, Alexandar Tzankov, Andrea Ballabio, Meredith A. Steeves, Min Liu, Frank C. Dorsey, Stephanie K. Schaub, Seongseok Yun, Weimin Li, Chunying Yang, Franz X. Schaub, Mario R. Fernandez
Supplementary Figure from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11460843442b0396c4b5e694004b1d76
https://doi.org/10.1158/0008-5472.22431508.v1
https://doi.org/10.1158/0008-5472.22431508.v1
Autor:
John L. Cleveland, Anders E. Berglund, John M. Koomen, Zhihua Chen, Alexandar Tzankov, Andrea Ballabio, Meredith A. Steeves, Min Liu, Frank C. Dorsey, Stephanie K. Schaub, Seongseok Yun, Weimin Li, Chunying Yang, Franz X. Schaub, Mario R. Fernandez
Supplementary Data from Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0460b6f75fe6376794a72fd32ccbb485
https://doi.org/10.1158/0008-5472.22431529.v1
https://doi.org/10.1158/0008-5472.22431529.v1
Autor:
John L. Cleveland, Anders E. Berglund, John M. Koomen, Zhihua Chen, Alexandar Tzankov, Andrea Ballabio, Meredith A. Steeves, Min Liu, Frank C. Dorsey, Stephanie K. Schaub, Seongseok Yun, Weimin Li, Chunying Yang, Franz X. Schaub, Mario R. Fernandez
MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcffed14ba84c38302a032e25ef525a9
https://doi.org/10.1158/0008-5472.c.6513925.v1
https://doi.org/10.1158/0008-5472.c.6513925.v1
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Purpose:Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune homeostasis and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d83fcda2c247c186c9439427cc003
https://doi.org/10.1158/1078-0432.c.6527882.v1
https://doi.org/10.1158/1078-0432.c.6527882.v1
Autor:
Mario R. Fernandez, Franz X. Schaub, Chunying Yang, Weimin Li, Seongseok Yun, Stephanie K. Schaub, Frank C. Dorsey, Min Liu, Meredith A. Steeves, Andrea Ballabio, Alexandar Tzankov, Zhihua Chen, John M. Koomen, Anders E. Berglund, John L. Cleveland
Publikováno v:
Cancer Res
MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7d577df9794dbe175e5101ab7a646b
http://hdl.handle.net/11588/883838
http://hdl.handle.net/11588/883838
Autor:
Christos A. Nicolaou, Christine Humblet, Hong Hu, Eva M. Martin, Frank C. Dorsey, Thomas M. Castle, Keith Ian Burton, Haitao Hu, Jorg Hendle, Michael J. Hickey, Joel Duerksen, Jibo Wang, Jon A. Erickson
Publikováno v:
ACS Medicinal Chemistry Letters. 10:278-286
[Image: see text] Increasing the success rate and throughput of drug discovery will require efficiency improvements throughout the process that is currently used in the pharmaceutical community, including the crucial step of identifying hit compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5ea952814b9dd8f845611595f68b37
https://doi.org/10.1021/acsmedchemlett.8b00488
https://doi.org/10.1021/acsmedchemlett.8b00488
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16783 (2011)
Genome reduction is a hallmark of obligate intracellular pathogens such as Chlamydia, where adaptation to intracellular growth has resulted in the elimination of genes encoding biosynthetic enzymes. Accordingly, chlamydiae rely heavily on the host ce
Externí odkaz:
https://doaj.org/article/41e40317d6144fc996f1e6a893407997