Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Frank C Nichols"'
Autor:
Alexander Bontempo, Alexandra Chirino, Alireza Heidari, Alexandra Lugo, Satoru Shindo, Maria R. Pastore, Riccardo Madonia, Sibel A. Antonson, Cristina Godoy, Frank C. Nichols, Jan Potempa, Mary Ellen Davey, Toshihisa Kawai, Mark J. Cayabyab
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT The COVID-19 pandemic persists despite the availability of vaccines, and it is, therefore, crucial to develop new therapeutic and preventive approaches. In this study, we investigated the potential role of oral microbiome in SARS-CoV-2 infec
Externí odkaz:
https://doaj.org/article/ca9be7f51c8d413ea79582e6281a76ce
Autor:
Shirin Ghods, Artur Muszyński, Hyojik Yang, Ratnam S. Seelan, Asal Mohammadi, Jacob S. Hilson, Griffin Keiser, Frank C. Nichols, Parastoo Azadi, Robert K. Ernst, Fata Moradali
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundThis study unveils the intricate functional association between cyclic di-3’,5’-adenylic acid (c-di-AMP) signaling, cellular bioenergetics, and the regulation of lipopolysaccharide (LPS) profile in Porphyromonas gingivalis, a Gram-negat
Externí odkaz:
https://doaj.org/article/1015e19a0cc64c33918977091768a1d6
Autor:
Benjamin Yu, Julia Kanaan, Hannah Shames, James Wicander, Makunda Aryal, Yunfeng Li, George Korza, Stanley Brul, Gertjan Kramer, Yong-qing Li, Frank C. Nichols, Bing Hao, Peter Setlow
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
2Duf, named after the presence of a transmembrane (TM) Duf421 domain and a small Duf1657 domain in its sequence, is likely located in the inner membrane (IM) of spores in some Bacillus species carrying a transposon with an operon termed spoVA2mob. Th
Externí odkaz:
https://doaj.org/article/e359860d0fff42fbbfe298de7c358097
Autor:
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host. Studies have shown that synthesis of these lipids (dihydroceramides [DHCs]) is invo
Externí odkaz:
https://doaj.org/article/bd65764485e146b3970171b41ba48073
Autor:
Courtney L. Millar, Liya Anto, Chelsea Garcia, Mi-Bo Kim, Anisha Jain, Anthony A. Provatas, Robert B. Clark, Ji-Young Lee, Frank C. Nichols, Christopher N. Blesso
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100192- (2022)
Oral and gut Bacteroidetes produce unique classes of serine-glycine lipodipeptides and glycine aminolipids that signal through host Toll-like receptor 2. These glycine lipids have also been detected in human arteries, but their effects on atheroscler
Externí odkaz:
https://doaj.org/article/97638e4dc9a04deb962fec36a945af7d
Autor:
Frank C. Nichols, Robert B. Clark, Mark W. Maciejewski, Anthony A. Provatas, Jeremy L. Balsbaugh, Floyd E. Dewhirst, Michael B. Smith, Amanda Rahmlow
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1645-1657 (2020)
Porphyromonas gingivalis is a Gram-negative anaerobic periodontal microorganism strongly associated with tissue-destructive processes in human periodontitis. Following oral infection with P. gingivalis, the periodontal bone loss in mice is reported t
Externí odkaz:
https://doaj.org/article/56dcaa6d33894f36a4e0c605a68138d7
Autor:
Frank C. Nichols, Kruttika Bhuse, Robert B. Clark, Anthony A. Provatas, Elena Carrington, Yu-Hsiung Wang, Qiang Zhu, Mary E. Davey, Floyd E. Dewhirst
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Toll-like receptor 2 (TLR2) activation has been implicated in the pathogenesis of periodontal disease but the identity of the TLR2 agonists has been an evolving story. The serine/glycine lipids produced by Porphyromonas gingivalis are reported to eng
Externí odkaz:
https://doaj.org/article/3c1d426a63a042f2b614d17c383c0c71
Autor:
Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter, Robert B. Clark
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination. Studies indicate that Toll-like receptor 2 (TLR2) signaling contributes to b
Externí odkaz:
https://doaj.org/article/56edee858d88429d8e4b78af18a06534
Autor:
Reza Nemati, Christopher Dietz, Emily J. Anstadt, Jorge Cervantes, Yaling Liu, Floyd E. Dewhirst, Robert B. Clark, Sydney Finegold, James J. Gallagher, Michael B. Smith, Xudong Yao, Frank C. Nichols
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1999-2007 (2017)
Multiple reaction monitoring-MS analysis of lipid extracts from human carotid endarterectomy and carotid artery samples from young individuals consistently demonstrated the presence of bacterial serine dipeptide lipid classes, including Lipid 654, an
Externí odkaz:
https://doaj.org/article/df9241ae138b4bc29b8ee4755f991d00
Autor:
George Korza, Sarah DePratti, Daniel Fairchild, James Wicander, Julia Kanaan, Hannah Shames, Frank C Nichols, Ann Cowan, Stanley Brul, Peter Setlow
Publikováno v:
Journal of Applied Microbiology, 134(3):lxad040. Wiley-Blackwell
AimsThis work aimed to characterize spore inner membrane (IM) properties and the mechanism of spore killing by wet heat and H2O2 with spores overexpressing the 2Duf protein, which is naturally encoded from a transposon found only in some Bacillus str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434d9d2429e6ca826fda01d615b6db8e
https://doi.org/10.1093/jambio/lxad040
https://doi.org/10.1093/jambio/lxad040