Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Frank C Ko"'
Autor:
Kyle D Anderson, Christian Beckmann, Saskia Heermant, Frank C Ko, Bryan Dulion, Imad Tarhoni, Jeffrey A Borgia, Amarjit S Virdi, Markus A Wimmer, D Rick Sumner, Ryan D Ross
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT An increasing number of patients with type 2 diabetes (T2DM) will require total joint replacement (TJR) in the next decade. T2DM patients are at increased risk for TJR failure, but the mechanisms are not well understood. The current study us
Externí odkaz:
https://doaj.org/article/e5de1822a7364e4cb362b8e66e444812
Autor:
Brittany M Wilson, Brittany R Witkiewics, Robin M Voigt, Christopher B Forysth, Ali Keshavarzian, Frank C Ko, Amarjit S Virdi, D Rick Sumner
Publikováno v:
JBMR Plus, Vol 6, Iss 3, Pp n/a-n/a (2022)
ABSTRACT Many lifestyle factors affect bone. Sleep deprivation increases risk for fractures and alcohol consumption can lead to alterations in the skeleton. How combined exposure to these two risk factors affects bone is unclear. Thus, we sought to d
Externí odkaz:
https://doaj.org/article/dcc11a2b65134f30a3ddb22a579a2157
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0250715 (2021)
Disuse-induced bone loss is seen following spinal cord injury, prolonged bed rest, and exposure to microgravity. We performed whole transcriptomic profiling of cortical bone using RNA sequencing (RNAseq) and RNA molecular barcoding (NanoString) on a
Externí odkaz:
https://doaj.org/article/90e739680cc34044a034ef5219db46f1
Publikováno v:
Journal of Orthopaedic Research. 40:1834-1843
Canonical Wnt signaling plays an important role in skeletal development, homeostasis, and both endochondral and intramembranous repair. While studies have demonstrated that the inhibition of Wnt signaling impairs intramembranous bone regeneration, ho
Autor:
Frank C. Ko, Sarah B. Jochum, Brittany M. Wilson, Amal Adra, Nikhil Patel, Hoomin Lee, Sherry Wilber, Maliha Shaikh, Christopher Forsyth, Ali Keshavarzian, Garth R. Swanson, D. Rick Sumner
Publikováno v:
Bone.
The circadian clock system regulates multiple metabolic processes, including bone metabolism. Previous studies have demonstrated that both central and peripheral circadian signaling regulate skeletal growth and homeostasis in mice. Disruption in cent
Autor:
Frank C. Ko, Spencer Fullam, Markus A. Wimmer, Amarjit S. Virdi, Ryan D. Ross, Kyle D. Anderson, Sumner
Publikováno v:
J Orthop Res
Bone microarchitectural parameters significantly contribute to implant fixation strength but the role of bone matrix composition is not well understood. To determine the relative contribution of microarchitecture and bone matrix composition to implan
Autor:
Frank C. Ko, D. Rick Sumner
Publikováno v:
Developmental Dynamics. 250:377-392
Postnatal intramembranous bone regeneration plays an important role during a wide variety of musculoskeletal regeneration processes such as fracture healing, joint replacement and dental implant surgery, distraction osteogenesis, stress fracture heal
Publikováno v:
Curr Osteoporos Rep
PURPOSE OF REVIEW: The purpose of this review is to critically evaluate the current literature regarding implant fixation in osteoporotic bone. RECENT FINDINGS: Clinical studies have not only demonstrated the growing prevalence of osteoporosis in pat
Autor:
Meghan M. Moran, Frank C. Ko, Larry D. Mesner, Gina M. Calabrese, Basel M. Al-Barghouthi, Charles R. Farber, D. Rick Sumner
Publikováno v:
Bone
There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been identified in human subj
Autor:
Frank C. Ko, Maleeha Mashiatulla, Matthew J. Meagher, Ryan D. Ross, Amarjit S. Virdi, Dale R. Sumner
Publikováno v:
J Orthop Res
Mechanical fixation of the implant to host bone is an important contributor to orthopaedic implant survivorship. The relative importance of bone-implant contact, trabecular bone architecture, and cortical bone geometry to implant fixation strength ha