Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Frank Burslem"'
Publikováno v:
The American Journal of Pathology. 171:32-42
Psoriasis has been considered an autoimmune, T cell-mediated disorder in which adaptive immune responses predominate over those of non-antigen-specific innate immunity. To test this hypothesis, we profiled the transcriptome of psoriatic tissue and co
Autor:
Franz Hofmann, Stuart J. Marshall, Gary Salmon, J. Thomas Peterson, Steve P. Watson, Robert Feil, Yotis A. Senis, Jocelyn M. Auger, Frank Burslem
Publikováno v:
Blood. 103:2601-2609
Glycoprotein Ib-IX-V (GPIb-IX-V) mediates platelet tethering to von Willebrand factor (VWF), recruiting platelets into the thrombus, and activates integrin αIIbβ3 through a pathway that is dependent on Src kinases. In addition, recent reports indic
Publikováno v:
Proceedings of the National Academy of Sciences. 99:2965-2970
UV radiation is the most important environmental skin aggressor, causing cancer and other problems. This paper reports the use of oligonucleotide microarray technology to determine changes in gene expression in human keratinocytes after UVB treatment
Autor:
Tom Forsén, Lars Lind, Shobha Potluri, Leif Groop, Yik Ying Teo, Andrew P. Morris, Frank Burslem, Jason Flannick, Torben Jørgensen, Tanya M. Teslovich, Noël P. Burtt, Jaspal S. Kooner, Patrick Sulem, Nicola L. Beer, Sekar Kathiresan, Ivan Brandslund, Heather M. Stringham, James G. Wilson, Jeff K. Trimmer, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Zachary Dymek, Yossi Farjoun, Tim Rolph, Unnur Thorsteinsdottir, Karen L. Mohlke, Jaakko Tuomilehto, John C. Chambers, Gudmar Thorleifsson, Rasmus Ribel-Madsen, Anubha Mahajan, Christian Fuchsberger, Jasmina Kravic, Kari Stefansson, Benjamin F. Voight, Craig L. Hanis, John Blangero, Veikko Salomaa, Desiree Douglas, Rafn Benediktsson, Benjamin Glaser, David R. Cox, Ann Marie Richard, Torben Hansen, Hanna Skärstrand, Gil Atzmon, Pål R. Njølstad, Suzanne B.R. Jacobs, Erik Ingelsson, Bo Isomaa, Yoon Shin Cho, Ayellet V. Segrè, Julia Brosnan, Thomas Meitinger, David Altshuler, Kristian Hveem, Astradur B. Hreidarsson, Pierre Fontanillas, Gisli Masson, Daniel F. Gudbjartsson, Cramer Christensen, Tiinamaija Tuomi, Augustine Kong, Fariba Vaziri-Sani, Anders Molven, Rainer Rauramaa, Niels Grarup, Stacey Gabriel, Michael Boehnke, Ravindranath Duggirala, Donald W. Bowden, Oluf Pedersen, Marit E. Jørgensen, Markku Laakso, Jong-Young Lee, Stefan Johansson, E. Shyong Tai, Allan Linneberg, Mark I. McCarthy, Timothy Fennell
Publikováno v:
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsen, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jorgensen, T, Jorgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Saloemaa, V, Segre, A V, Skarstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Voight, B F, Boehnke, M, McCarthy, M I, Njolstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K, Altshuler, D, Go, T D C & Consortium, T D-G 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Nature Genetics; Vol 46
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsén, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jørgensen, T, Jørgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Salomaa, V, Segrè, A V, Skärstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Wilson, J G, Boehnke, M, McCarthy, M I, Njølstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K & Altshuler, D 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Nature Genetics; Vol 46
Flannick, J, Thorleifsson, G, Beer, N L, Jacobs, S B R, Grarup, N, Burtt, N P, Mahajan, A, Fuchsberger, C, Atzmon, G, Benediktsson, R, Blangero, J, Bowden, D W, Brandslund, I, Brosnan, J, Burslem, F, Chambers, J, Cho, Y S, Christensen, C, Douglas, D A, Duggirala, R, Dymek, Z, Farjoun, Y, Fennell, T, Fontanillas, P, Forsén, T, Gabriel, S, Glaser, B, Gudbjartsson, D F, Hanis, C, Hansen, T, Hreidarsson, A B, Hveem, K, Ingelsson, E, Isomaa, B, Johansson, S, Jørgensen, T, Jørgensen, M E, Kathiresan, S, Kong, A, Kooner, J, Kravic, J, Laakso, M, Lee, J Y, Lind, L, Lindgren, C M, Linneberg, A, Masson, G, Meitinger, T, Mohlke, K L, Molven, A, Morris, A P, Potluri, S, Rauramaa, R, Ribel-Madsen, R, Richard, A M, Rolph, T, Salomaa, V, Segrè, A V, Skärstrand, H, Steinthorsdottir, V, Stringham, H M, Sulem, P, Tai, E S, Teo, Y Y, Teslovich, T, Thorsteinsdottir, U, Trimmer, J K, Tuomi, T, Tuomilehto, J, Vaziri-Sani, F, Voight, B F, Wilson, J G, Boehnke, M, McCarthy, M I, Njølstad, P R, Pedersen, O, Groop, L, Cox, D R, Stefansson, K & Altshuler, D 2014, ' Loss-of-function mutations in SLC30A8 protect against type 2 diabetes ', Nature Genetics, vol. 46, no. 4, pp. 357-363 . https://doi.org/10.1038/ng.2915
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b7f58ef7f0659b2cc5ed7dd42c8306
https://portal.findresearcher.sdu.dk/da/publications/49910ede-b220-458f-a961-6e9f6447521c
https://portal.findresearcher.sdu.dk/da/publications/49910ede-b220-458f-a961-6e9f6447521c
Autor:
Tim Rolph, Christopher Newton-Cheh, Jeff K. Trimmer, Ervin R. Fox, Jose C. Florez, Joel N. Hirschhorn, Leif Groop, Anders Molven, Christine E. Seidman, David R. Cox, Henrik Irgens, Pål R. Njølstad, Stacey Gabriel, Nicola L. Beer, Sekar Kathiresan, Christopher J. O'Donnell, James G. Wilson, Alexander G. Bick, Vineeta Agarwala, James B. Meigs, Stefan Johansson, Frank Burslem, M. Julia Brosnan, Herman A. Taylor, Namrata Gupta, David Altshuler, Valeriya Lyssenko, Noël P. Burtt, Janne Molnes, Tiinamaija Tuomi, Jason Flannick, Jonathan G. Seidman
Publikováno v:
Nature Genetics
Genome sequencing can identify individuals in the general population who harbor rare coding variants in genes for Mendelian disorders1–7 – and who consequently may have increased disease risk. However, previous studies of rare variants in phenoty
Publikováno v:
ChemInform. 32
Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a–o and their carboxylic acid analogues 2a–o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH2)3Ph, P2′=t-Bu) select
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(4)
Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a–o and their carboxylic acid analogues 2a–o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH2)3Ph, P2′=t-Bu) select
Autor:
Shawn P. Macauley, Jane S. Gibson, Gillian Murphy, Gregory S. Schultz, Michael Stacey, Frank Burslem, Neil T. Bennett, Naomi Trengove
Publikováno v:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 7(6)
To assess the differences in proteolytic activity of acute and chronic wound environments, wound fluids were collected from acute surgical wounds (22 samples) and chronic wounds (25 samples) of various etiologies, including mixed vessel disease ulcer
Autor:
Shawn P. Macauley, Jane S. Gibson, Lyle L. Moldawer, Naomi Trengrove, Michael Stacey, Roy W. Tarnuzzer, Bruce A. Mast, Gregory S. Schultz, Frank Burslem
Publikováno v:
Growth Factors and Wound Healing ISBN: 9781461273219
Wound healing in the skin is a complex biological process that has been extensively characterized at the light microscope level. However, regulation of skin wound healing is only partially understood at the molecular level. Skin wound healing can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdbe17d1bb78245610cb37a55bd7a49b
https://doi.org/10.1007/978-1-4612-1876-0_12
https://doi.org/10.1007/978-1-4612-1876-0_12
Publikováno v:
Genome Biology. 6:R5
Wound healing is a complex process requiring the collaborative efforts of different tissues and cell lineages, and involving the coordinated interplay of several phases of proliferation, migration, matrix synthesis and contraction. Tissue damage also