Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Frank Burkamp"'
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
BRAFV600E mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d6408b8cab0676bbd02a08487f75275
https://doi.org/10.1158/1535-7163.c.6538074.v1
https://doi.org/10.1158/1535-7163.c.6538074.v1
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
Table S1: Top 20 pathways identified by IPA containing genes significantly upregulated between poor and good prognostic BRAFMT stage II/III CRC in GSE39582; Table S2: Top 20 pathways identified by IPA containing genes significantly downregulated betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b887ea2b5d55c1a80d85664426d65089
https://doi.org/10.1158/1535-7163.22505463
https://doi.org/10.1158/1535-7163.22505463
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31719381cc8c9646ee4cd28f7f8621c1
https://doi.org/10.1158/1535-7163.22505460
https://doi.org/10.1158/1535-7163.22505460
Autor:
Ian G. Mills, Claudio Isella, Jessica-Anne Weir, Frank Burkamp, Nicholas Forsythe, Arman Javadi, Wendy L. Allen, Patrick G. Johnston, Heba Emam, Hajrah Khawaja, Puthen V. Jithesh, Alaa Refaat, Sandra Van Schaeybroeck, Vlad Popovici, Melissa J. LaBonte
Publikováno v:
Queen's University Belfast-PURE
Forsythe, N, Refaat, A, Javadi, A, Khawaja, H, Weir, J-A, Emam, H, Allen, W L, Burkamp, F, Popovici, V, Jithesh, P V, Isella, C, Labonte, M J, Mills, I G, Johnston, P G & Van Schaeybroeck, S 2018, ' The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer ', Molecular Cancer Therapeutics . https://doi.org/10.1158/1535-7163.MCT-17-0603
Forsythe, N, Refaat, A, Javadi, A, Khawaja, H, Weir, J-A, Emam, H, Allen, W L, Burkamp, F, Popovici, V, Jithesh, P V, Isella, C, Labonte, M J, Mills, I G, Johnston, P G & Van Schaeybroeck, S 2018, ' The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer ', Molecular Cancer Therapeutics . https://doi.org/10.1158/1535-7163.MCT-17-0603
BRAF V600E mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0e2d5386ed420b89f0e97e61b9730e
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Nicholas, Forsythe, Alaa, Refaat, Arman, Javadi, Hajrah, Khawaja, Jessica-Anne, Weir, Heba, Emam, Wendy L, Allen, Frank, Burkamp, Vlad, Popovici, Puthen V, Jithesh, Claudio, Isella, Melissa J, Labonte, Ian G, Mills, Patrick G, Johnston, Sandra, Van Schaeybroeck
Publikováno v:
Molecular cancer therapeutics. 17(6)
BRAFV600E mutations occur in ~10% of colorectal cancer (CRC) cases, are associated with poor survival and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbf58fc285411c22fcdaae70e02b8efd
https://pubmed.ncbi.nlm.nih.gov/29483217
https://pubmed.ncbi.nlm.nih.gov/29483217
Autor:
Ewelina Rozycka, Stephanie Burton, Natalie Page, Christina Bell, Steven Whitehead, Matthew Helm, Colin O'Dowd, Oliver Barker, Frank Burkamp, Steven Shepherd, Gerald Gavory, Eamon Cassidy, Shane Rountree, Tim Harrison, Peter Hewitt, Xavier Jacq, Mark Wappett
Publikováno v:
Cancer Research. 79:LB-049
The current interest in protein homeostasis as a therapeutic strategy has highlighted the importance of protein ubiquitination as a post-translational modification. Protein degradation has been enabled by several approaches (e.g. small molecule degra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b335541ffa3408590a07af3c2fc2b81e
https://doi.org/10.1158/1538-7445.am2019-lb-049
https://doi.org/10.1158/1538-7445.am2019-lb-049
Autor:
Adam Treder, Gerald Gavory, Frank Burkamp, Robert M. Mader, Christophe Chardonnens, Tim Harrison, Grégoire Vuagniaux, Stefania Rigotti, Caroline Boyd, Frederic Massière, Colin O'Dowd, Anne Vaslin Chessex, Andrea Zaffalon, Astrid A. Glück
Publikováno v:
Cancer Research. 79:4423-4423
Background: The Wee1 tyrosine kinase is activated upon DNA damage and regulates the G2-M cell cycle checkpoint. Inhibition of Wee1, in conjunction with additional genetic alterations and/or addition of a DNA damaging agent, results in mitotic catastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afb4a2c289317b603d1a2dfe9aaa95aa
https://doi.org/10.1158/1538-7445.am2019-4423
https://doi.org/10.1158/1538-7445.am2019-4423
Autor:
Colin O'Dowd, Adam Treder, Eamon Cassidy, Joana Costa, Christina Bell, Ashling Henderson, Gerald Gavory, Oliver Barker, Ewelina Rozycka, Matt Helm, Timothy Harrison, Natalie Page, Frank Burkamp, Mary McFarland, Anthony Dossang, Mark Wappett, Steven Shepherd, Hugues Miel, Peter Hewitt, Stephanie Burton, Caroline Hughes, Shane Rountree, Lauren Proctor, Steven Whitehead
Publikováno v:
Cancer Research. 78:1935-1935
Over the past decade, protein ubiquitination has emerged as an important post-translational modification with regulatory functions in all important cellular processes. Deubiquitinating enzymes (DUBs) including ubiquitin specific proteases (USPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aadcc8acfb17ff79c7e20112a76d2c81
https://doi.org/10.1158/1538-7445.am2018-1935
https://doi.org/10.1158/1538-7445.am2018-1935
Autor:
Zenobia C. D’Costa, Paul B. Mullan, Samira Bouzzaoui, Kishore K.D. Gaddale, Sharon L. Eddie, Kerry A. Ness, Rich Williams, Andrew Young, Dominic Janssen, Christopher J. Scott, Frank Burkamp, Catherine A. Higgins, Amy Templeman, Tim Harrison, Roberta E. Burden, Linda Jordan
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(23)
This Letter describes the continued SAR exploration of small molecule Legumain inhibitors with the aim of developing a potent and selective in vitro tool compound. Work continued in this Letter explores the use of alternative P2-P3 linker units and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014805c56ecb7f3a57c57c4f1c135caf
https://pubmed.ncbi.nlm.nih.gov/26522952
https://pubmed.ncbi.nlm.nih.gov/26522952
Autor:
Frank Burkamp, Kevin J. Hodgetts, Rajagopal Bakthavatchalam, Robert Clarkson, Hutchison Alan J, Stéphane De Lombaert, Daniel N. Cortright, A. Brian Jones, Charles A. Blum, Peter Blurton, Harry Brielmann, Xiaozhang Zheng, Jayaraman Chandrasekhar, Marci Crandall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5217-5221
Bioisosteric replacement of piperazine with an aryl ring in lead VR1 antagonist 1 led to the biarylamide series. The development of B-ring SAR led to the conformationally constrained analog 70. The resulting aminoquinazoline 70 represents a novel VR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfc1872ffb6d5bc79dc219aaca6d3f4
https://doi.org/10.1016/j.bmcl.2006.07.010
https://doi.org/10.1016/j.bmcl.2006.07.010