Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frank Buquicchio"'
Autor:
Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli, Luisa Albano, Carrie Margulies, Frank Buquicchio, Elena Fontana, Stefano Beretta, Ivan Merelli, Andrea Cappelleri, Paola MV Rancoita, Vassilios Lougaris, Alessandro Plebani, Maria Kanariou, Arjan Lankester, Francesca Ferrua, Eugenio Scanziani, Cecilia Cotta‐Ramusino, Anna Villa, Luigi Naldini, Pietro Genovese
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-25 (2021)
Abstract Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X‐linked hyper‐IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here, we developed a on
Externí odkaz:
https://doaj.org/article/9aef4eba41804327af789ffa8b24647a
Autor:
Anne Bothmer, Tanushree Phadke, Luis A. Barrera, Carrie M Margulies, Christina S. Lee, Frank Buquicchio, Sean Moss, Hayat S. Abdulkerim, William Selleck, Hariharan Jayaram, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
CRISPR-Cas9 has rapidly become a common molecular biology tool for modifying genomes and has been modified to generate single-strand nicks as well as double-strand breaks. Here the authors explore the DNA repair pathways activated by the different va
Externí odkaz:
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
Autor:
Karyn Schmidt, Cailin E. Joyce, Frank Buquicchio, Adam Brown, Justin Ritz, Robert J. Distel, Charles H. Yoon, Carl D. Novina
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 2025-2037 (2016)
Long non-coding RNAs (lncRNAs) have been implicated in numerous physiological processes and diseases, most notably cancers. However, little is known about the mechanism of many functional lncRNAs. We identified an abundantly expressed lncRNA associat
Externí odkaz:
https://doaj.org/article/a0d312177fc84848ba8b1e3d13f865fa
Autor:
Ansuman T. Satpathy, Frank Buquicchio
Publikováno v:
Trends Immunol
CRISPR-Cas9 technologies have transformed the study of genetic pathways governing cellular differentiation and function. Recent advances have adapted these methods to immune cells, which has accelerated the pace of functional genomics in immunology a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69669c88efe8bc61cfff7797fa04345
https://doi.org/10.1016/j.it.2021.03.003
https://doi.org/10.1016/j.it.2021.03.003
Autor:
Cecilia Cotta-Ramusino, Hayat S Abdulkerim, Eugenio Marco, Frank Buquicchio, Cecilia Fernández, John A. Zuris, Lucas Cohen, Ramya Viswanathan, Kenneth W Gareau, Anne Bothmer, Vic E. Myer
Publikováno v:
The CRISPR Journal. 3:177-187
Multiplexed genome editing with DNA endonucleases has broad application, including for cellular therapies, but chromosomal translocations, natural byproducts of inducing simultaneous genomic breaks, have not been explored in detail. Here we apply var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506b5c5ea84f305da86d539021e88dce
https://doi.org/10.1089/crispr.2019.0074
https://doi.org/10.1089/crispr.2019.0074
Autor:
Frank Buquicchio, Raissa Fonseca, Julia Belk, Maximilien Evrard, Andreas Obers, Yanyan Qi, Bence Daniel, Kathryn Yost, Ansuman T. Satpathy, Laura K. Mackay
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bdb6fb0070f3718168ffc4f233c146
https://doi.org/10.2139/ssrn.4099073
https://doi.org/10.2139/ssrn.4099073
Autor:
Luis A. Barrera, Hayat S Abdulkerim, Frank Buquicchio, Hariharan Jayaram, Carrie M Margulies, Tanushree Phadke, Christina S. Lee, Anne Bothmer, William Selleck, Sean Moss, Vic E. Myer, Cecilia Cotta-Ramusino
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa93048e8052b83f4e7c2904994bda74
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
https://doaj.org/article/0e7ab32becea4c83bb655f0d5113f731
Publikováno v:
Journal of Biological Methods. 4:e67
Long non-coding RNAs (lncRNAs) regulate critical cellular processes and their dysregulation contributes to multiple diseases. Although only a few lncRNAs have defined mechanisms, many of these characterized lncRNAs interact with transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3256b6d1399fcf3aa5079f598c863d6
https://doi.org/10.14440/jbm.2017.171
https://doi.org/10.14440/jbm.2017.171
Autor:
Will Selleck, Blythe D. Sather, Jon C. Jones, G. Grant Welstead, Christopher Heath Nye, Alex Baturevych, Justin Fang, McKensie Collins, Hari Jayaram, Frank Buquicchio, Sherri Mudri, David Bumcrot, Ruth Salmon
Publikováno v:
Molecular Therapy. 24:S229
Cancer immunotherapy is an exciting area of cancer treatment bolstered by recent success of anti-immune checkpoint antibodies in the clinic. Engineered T cells that are programmed to attack tumors via chimeric antigen receptors (CARs) have also shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31a8e95f7462c6aee43b4c2510b439e8
https://doi.org/10.1016/s1525-0016(16)33380-9
https://doi.org/10.1016/s1525-0016(16)33380-9
Autor:
Giulia Schiroli, Elisabetta Mercuri, Andrea Cappelleri, Anna Villa, Genni Enza Marcovecchio, Maria Kanariou, Vassilios Lougaris, Frank Buquicchio, Maria Carmina Castiello, Valentina Vavassori, Carrie M Margulies, Cecilia Cotta-Ramusino, Luigi Naldini, Francesca Ferrua, Stefano Beretta, Eugenio Scanziani, Alessandro Plebani, Arjan C. Lankester, Ivan Merelli, Luisa Albano, Paola Mv Rancoita, Pietro Genovese, Elena Fontana
Publikováno v:
EMBO Molecular Medicine, 13(3). WILEY
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine
Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X‐linked hyper‐IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here, we developed a one‐size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dfdfa21081fbd5ebc50e8159a16629