Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Frank Bradke"'
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002267 (2023)
Science does not take place in a vacuum: The physical and social workplace has a profound influence on scientific discoveries. Everyone at a research institute can contribute to its scientific output and productivity, from faculty research groups to
Externí odkaz:
https://doaj.org/article/91401429b26e4dcd93306228a9f7fdc9
Autor:
Jarred M Griffin, Frank Bradke
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-29 (2020)
Abstract The recent years saw the advent of promising preclinical strategies that combat the devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials. However, individually, these treatments produce only modest l
Externí odkaz:
https://doaj.org/article/1c25af98327d4a3bb36110b1cf7fd81d
Autor:
Irina Alecu, Andrea Tedeschi, Natascha Behler, Klaus Wunderling, Christian Lamberz, MarioA.R. Lauterbach, Anne Gaebler, Daniela Ernst, Paul P. Van Veldhoven, Ashraf Al-Amoudi, Eicke Latz, Alaa Othman, Lars Kuerschner, Thorsten Hornemann, Frank Bradke, Christoph Thiele, Anke Penno
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 42-59 (2017)
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, su
Externí odkaz:
https://doaj.org/article/e23646b731034a248bd71501da457f6c
Autor:
Chintan Chhatbar, Claudia N. Detje, Elena Grabski, Katharina Borst, Julia Spanier, Luca Ghita, David A. Elliott, Marta Joana Costa Jordão, Nora Mueller, James Sutton, Chittappen K. Prajeeth, Viktoria Gudi, Michael A. Klein, Marco Prinz, Frank Bradke, Martin Stangel, Ulrich Kalinke
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 118-129.e4 (2018)
Summary: In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon int
Externí odkaz:
https://doaj.org/article/bbf9da8643584d2ba5d0dca8adc964b6
Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis
Autor:
Fanny Ehret, Steffen Vogler, Sherin Pojar, David A. Elliott, Frank Bradke, Barbara Steiner, Gerd Kempermann
Publikováno v:
Neurobiology of Disease, Vol 75, Iss , Pp 131-141 (2015)
Could impaired adult hippocampal neurogenesis be a relevant mechanism underlying CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)? Memory symptoms in CADASIL, the most common hereditary form of vasc
Externí odkaz:
https://doaj.org/article/8e5c748dd5dc49a985f6fd278e852a05
Autor:
Morgane Belle, David Godefroy, Chloé Dominici, Céline Heitz-Marchaland, Pavol Zelina, Farida Hellal, Frank Bradke, Alain Chédotal
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1191-1201 (2014)
Clearing techniques have been developed to transparentize mouse brains, thereby preserving 3D structure, but their complexity has limited their use. Here, we show that immunolabeling of axonal tracts followed by optical clearing with solvents (3DISCO
Externí odkaz:
https://doaj.org/article/79c5b43caa5b408187a1c34a93ac2398
Autor:
Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlüter, Frank Bradke, Jianrong Lu, André Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 1, Pp 52-63 (2012)
Abstract Histone deacetylases (HDACs) are currently being discussed as promising therapeutic targets to treat neurodegenerative diseases. However, the role of specific HDACs in cognition and neurodegeneration remains poorly understood. Here, we inves
Externí odkaz:
https://doaj.org/article/5404a8897502471e8a704c0dbd7a484c
Autor:
Diana Raju, Sophie Schonauer, Hussein Hamzeh, Kevin C Flynn, Frank Bradke, Katharina Vom Dorp, Peter Dörmann, Yildiz Yildiz, Christian Trötschel, Ansgar Poetsch, Bernadette Breiden, Konrad Sandhoff, Heinz G Körschen, Dagmar Wachten
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005063 (2015)
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellular functions. Accumulation of the simple glycosphingolipid glucosylceramide results in life-threatening lipid storage-diseases or in male infertility.
Externí odkaz:
https://doaj.org/article/84518ab1fa044772b1427f7ce8368369
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002406 (2011)
During herpes simplex virus 1 (HSV1) egress in neurons, viral particles travel from the neuronal cell body along the axon towards the synapse. Whether HSV1 particles are transported as enveloped virions as proposed by the 'married' model or as non-en
Externí odkaz:
https://doaj.org/article/d4b83b637cd341a4a55b3bf045e70ca9
Autor:
Jarred M Griffin, Sonia Hingorani Jai Prakash, Till Bockemühl, Jessica M Benner, Barbara Schaffran, Victoria Moreno-Manzano, Ansgar Büschges, Frank Bradke
Publikováno v:
Brain communications 5(1), fcad005 (2023). doi:10.1093/braincomms/fcad005
Microtubule stabilization through epothilones is a promising preclinical therapy for functional recovery following spinal cord injury that stimulates axon regeneration, reduces growth-inhibitory molecule deposition and promotes functional improvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa36aceccafe34765c3d639df66c999f
https://pub.dzne.de/record/249930
https://pub.dzne.de/record/249930
