Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Frank Bolkenius"'
Autor:
Axel J. Ganzhorn, Frank Bolkenius
Publikováno v:
General Pharmacology: The Vascular System. 31:655-659
1. Peptidylglycine alpha-amidating mono-oxygenase (PAM) is a bifunctional key enzyme in the bioactivation of neuropeptides. Its biosynthesis, distribution, functional role, and pharmacological manipulation are discussed. 2. PAM biosynthesis from a si
Publikováno v:
European Journal of Pharmacology. 298:37-43
Neurological disorders, such as stroke, trauma, tardive dyskinesia, Alzheimer's and Parkinson's diseases, may be partially attributed to excessive exposition of the nervous tissue to oxygen-derived radicals. A novel water-soluble α-tocopherol analog
Publikováno v:
European Journal of Pharmacology. 255:215-222
Oxygen-derived free radicals are involved in myocardial reperfusion injury. In the present study MDL 74,405 (S-(-)-3,4-dihydro-6-hydroxy-N,N,N-2,5,7,8-heptamethyl-2H-1-benzo pyran-2-ethanaminium 4-methylbenzenesulfonate), a hydrophilic derivative of
Publikováno v:
European Journal of Pharmacology. 233:63-70
Free radicals may cause part of the irreversible injury which occurs during myocardial infarction and reperfusion. In the present study MDL 73404, a hydrophilic, cardioselective, free radical scavenger analogue of alpha-tocopherol, was evaluated for
Publikováno v:
ChemInform. 26
Analogues of alpha-tocopherol and ascorbic acid with permanently cationic substituents, i.e., phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were synthesized, and the 2R and 2S enantiomers of the alpha-tocophe
Autor:
Frank Bolkenius
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1095:23-29
Human leukocytes stimulated by opsonized zymosan increase their NADPH oxidase-catalysed reduction of molecular oxygen. This leads to enhanced formation of superoxyl radicals and subsequently hydrogen peroxide. The leukocyte enzyme myeloperoxidase gen
Autor:
E. R. Wagner, M. A. Petty, J. Dow, Joseph Wagner, J. M. Grisar, W. De Jong, K. D. Haegele, Frank Bolkenius
Publikováno v:
Journal of Medicinal Chemistry. 34:257-260
The alpha-tocopherol analogue 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8- heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate (1a, MDL 73404) and its O-acetate 1b (MDL 74270) were synthesized. Compound 1a was found to be hydrophilic (log P =
Publikováno v:
Biochemical pharmacology. 53(11)
Peptidylglycine α-hydroxylating monooxygenase (PHM; EC 1.14.17.3) catalyses the ratelimiting step in the post-translational activation of substance P, among other neuropeptides, from its glycine-extended precursor. Comparative kinetic studies were p
Publikováno v:
Journal of medicinal chemistry. 38(15)
Analogues of alpha-tocopherol and ascorbic acid with permanently cationic substituents, i.e., phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were synthesized, and the 2R and 2S enantiomers of the alpha-tocophe
Autor:
Denis Monard, Frank Bolkenius
Publikováno v:
Neurochemistry international. 26(6)
Neuronal viability is affected by reactive oxygen species. Lipid peroxidation is often defined as a major reason for cellular breakdown. Additionally, certain indispensable proteins are possible targets for excessively formed reactive oxygen species.