Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Frank B, Furnari"'
Autor:
Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma, Anthony Y. Jeong, Jacqueline Lara, Nancy K. Tran, Jeffrey M. Smith, Jeremy N. Rich, J. Silvio Gutkind, Shigeki Miyamoto, Frank B. Furnari, Joan Heller Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In silico interrogation of glioblastoma (GBM) in The Cancer Genome Atlas (TCGA) revealed upregulation of GNA12 (Gα12), encoding the alpha subunit of the heterotrimeric G-protein G12, concomitant with overexpression of multiple G-protein cou
Externí odkaz:
https://doaj.org/article/e419c358a7d24206a72d5cdef498840f
Autor:
Frank B. Furnari, Corina Anastasaki, Shan Bian, Howard A. Fine, Tomoyuki Koga, Lu Q. Le, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/ce1de40fcd154f57adc3a04a5aab3822
Autor:
Peiyu Wang, Renwu Zhou, Rusen Zhou, Shuo Feng, Liqian Zhao, Wenshao Li, Jinyong Lin, Aleksandra Rajapakse, Chia-Hwa Lee, Frank B. Furnari, Antony W. Burgess, Jennifer H. Gunter, Gang Liu, Kostya (Ken) Ostrikov, Derek J. Richard, Fiona Simpson, Xiaofeng Dai, Erik W. Thompson
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 102976- (2024)
Cold atmospheric plasma (CAP) holds promise as a cancer-specific treatment that selectively kills various types of malignant cells. We used CAP-activated media (PAM) to utilize a range of the generated short- and long-lived reactive species. Specific
Externí odkaz:
https://doaj.org/article/ca52f582515c4dddb079d227045ead42
Autor:
Tomoyuki Koga, Isaac A. Chaim, Jorge A. Benitez, Sebastian Markmiller, Alison D. Parisian, Robert F. Hevner, Kristen M. Turner, Florian M. Hessenauer, Matteo D’Antonio, Nam-phuong D. Nguyen, Shahram Saberi, Jianhui Ma, Shunichiro Miki, Antonia D. Boyer, John Ravits, Kelly A. Frazer, Vineet Bafna, Clark C. Chen, Paul S. Mischel, Gene W. Yeo, Frank B. Furnari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The dearth of glioblastoma model systems that accurately recapitulate the disease remains a challenge. Here, the authors develop cancer avatars using genetically engineered human induced pluripotent cells.
Externí odkaz:
https://doaj.org/article/129339bec1d846d6beb84462802c2cb9
Autor:
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957- (2021)
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodies
Externí odkaz:
https://doaj.org/article/8516b7196aa84c49af33aefb9f94a103
Autor:
Elisa Helena Farias Jandrey, Marcelle Bezerra, Lilian Tiemi Inoue, Frank B. Furnari, Anamaria Aranha Camargo, Érico Tosoni Costa
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
There are no effective strategies for the successful treatment of glioblastomas (GBM). Current therapeutic modalities effectively target bulk tumor cells but leave behind marginal GBM cells that escape from the surgical margins and radiotherapy field
Externí odkaz:
https://doaj.org/article/dee71aedd8e94a8a974125ad8932222a
Autor:
Benjamin Lin, Julia Ziebro, Erin Smithberger, Kasey R Skinner, Eva Zhao, Timothy F Cloughesy, Zev A Binder, Donald M O’Rourke, David A Nathanson, Frank B Furnari, C Ryan Miller
Publikováno v:
Neuro-Oncology. 24:2035-2062
The Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal neoplasm glioblastoma (GBM) that through a series of negative clinical t
Autor:
Jorge A. Benitez, Jianhui Ma, Matteo D’Antonio, Antonia Boyer, Maria Fernanda Camargo, Ciro Zanca, Stephen Kelly, Alireza Khodadadi-Jamayran, Nathan M. Jameson, Michael Andersen, Hrvoje Miletic, Shahram Saberi, Kelly A. Frazer, Webster K. Cavenee, Frank B. Furnari
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
PTEN mutations are frequent in glioblastoma and often are associated with therapeutic resistance. Here, the authors demonstrate that PTEN regulates gene expression at the chromatin level by interacting with the histone chaperone DAXX and H3.3, and th
Externí odkaz:
https://doaj.org/article/552fe99f5f044c3ab87a7c0942b022b9
Autor:
Toshiyasu Taniguchi, Frank B. Furnari, Muneesh Tewari, Xiaofeng Zhou, Patrick S. Mitchell, Webster K. Cavenee, Ming Li, Jen-Wei Huang, Yemin Wang
Precise regulation of DNA damage response is crucial for cellular survival after DNA damage, and its abrogation often results in genomic instability in cancer. Phosphorylated histone H2AX (γH2AX) forms nuclear foci at sites of DNA damage and facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d89b363157a71694822535dbe9620eb
https://doi.org/10.1158/1541-7786.c.6542050
https://doi.org/10.1158/1541-7786.c.6542050
Autor:
Toshiyasu Taniguchi, Frank B. Furnari, Muneesh Tewari, Xiaofeng Zhou, Patrick S. Mitchell, Webster K. Cavenee, Ming Li, Jen-Wei Huang, Yemin Wang
PDF file - 1581K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1bac8c7412c775504eadbfcee02f81
https://doi.org/10.1158/1541-7786.22518658.v1
https://doi.org/10.1158/1541-7786.22518658.v1