Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Frank A. Sinicrope"'
Autor:
Michael H. Storandt, Kara R. Rogen, Anushka Iyyangar, Rylie R. Schnell, Jessica L. Mitchell, Joleen M. Hubbard, Frank A. Sinicrope, Aminah Jatoi, Amit Mahipal, Qian Shi, Zhaohui Jin
Publikováno v:
Cancers, Vol 15, Iss 14, p 3570 (2023)
Over the past 20 years, rates of early-onset colorectal cancer (eoCRC), defined as MUTYH (4.8%), CHEK2 (3.6%), APC, BMPR1A, and TP53 (1.3% each). Among those with aoCRC, 109 patients (61%) completed genetic testing, among which 88% had either a dMMR
Externí odkaz:
https://doaj.org/article/c8400c426c764414b713c0f79eed4fe2
Autor:
Ferga C. Gleeson, Michael J. Levy, Anja C. Roden, Lisa A. Boardman, Frank A. Sinicrope, Robert R. McWilliams, Lizhi Zhang
Publikováno v:
Endoscopy International Open, Vol 06, Iss 10, Pp E1278-E1282 (2018)
Background and study aims The US FDA recently approved a cancer treatment with pembrolizumab based upon the tumor biomarker status of deficient mismatch repair (dMMR) rather than a specific disease-based approach. We sought to determine if endoscopic
Externí odkaz:
https://doaj.org/article/19f61d0b612243309f5607f2127fa67f
Autor:
Zhaohui Jin, Frank A. Sinicrope
Publikováno v:
Cancers, Vol 13, Iss 2, p 300 (2021)
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Universal MMR/MSI testing is standard of care for all patients with newly diagnosed CRC based on multi-society guidelines in the United States. Such testing is intended to
Externí odkaz:
https://doaj.org/article/bd8b94befd1647129fa60ca483ccbb35
Autor:
Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann
Publikováno v:
Haematologica, Vol 99, Iss 1 (2014)
Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers di
Externí odkaz:
https://doaj.org/article/c8ce24c260924fff83b4f73d3d068613
Autor:
Claire Gallois, Qian Shi, Jeffrey P. Meyers, Timothy Iveson, Steven R. Alberts, Aimery de Gramont, Alberto F. Sobrero, Daniel G. Haller, Eiji Oki, Anthony Frank Shields, Richard M. Goldberg, Rachel Kerr, Sara Lonardi, Greg Yothers, Caroline Kelly, Ioannis Boukovinas, Roberto Labianca, Frank A. Sinicrope, Ioannis Souglakos, Takayuki Yoshino, Jeffrey A. Meyerhardt, Thierry André, Demetris Papamichael, Julien Taieb
Publikováno v:
Journal of Clinical Oncology. 41:803-815
PURPOSE Oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (CC) for 6 months remains a standard in high-risk stage III patients. Data are lacking as to whether early discontinuation of all treatment (ETD) or early discont
Supplementary Figure 1 legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806cded3b7d93cd37fe86e00fc59a6dd
https://doi.org/10.1158/1541-7786.22593321
https://doi.org/10.1158/1541-7786.22593321
Deubiquitinases identified from the Biogrid database that may potentially interact with ZEB1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c72f5f344cfbe0ac948ced3c19093f
https://doi.org/10.1158/1541-7786.22593318
https://doi.org/10.1158/1541-7786.22593318
Schematic Model. Constitutive activation of the RAS/RAS/MEK/ERK axis phosphorylates the deubiquitinase USP10 at serine 236, and this phosphorylation induces the dissociation of USP10 from ZEB1 resulting in stabilization of ZEB1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191a2b40a2519471f6a2d9d87eedcb73
https://doi.org/10.1158/1541-7786.22593324
https://doi.org/10.1158/1541-7786.22593324
Zinc finger E-box–binding homeobox 1 (ZEB1) is a transcription factor that can promote tumor invasion and metastasis by inducing epithelial-to-mesenchymal transition (EMT). To date, regulation of ZEB1 by RAS/RAF signaling remains unclear, and few s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fdbaaf7bca6af5f1454d7a63fca1ea
https://doi.org/10.1158/1541-7786.c.6573876.v1
https://doi.org/10.1158/1541-7786.c.6573876.v1
Autor:
Stephen Sontag, Chung S. Yang, Nathan R. Foster, Jeffrey P. Meyers, Paul J. Limburg, Asad Umar, Gary Della'Zanna, Árpád V. Patai, Abdul M. Kalaiger, Christopher J. Gostout, John B. Kisiel, Robert E. Sedlack, Mark V. Larson, Robert E. Kraichely, Kenneth W. Schroeder, Louis M. Wong Kee Song, Navtej S. Buttar, Thomas R. Viggiano, Frank A. Sinicrope
Polyphenon E (Poly E) is a green tea polyphenol preparation whose most active component is epigallocatechin gallate (EGCG). We studied the cancer preventive efficacy and safety of Poly E in subjects with rectal aberrant crypt foci (ACF), which repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f977b030648386dc91fb713987725e
https://doi.org/10.1158/1940-6207.c.6546958.v1
https://doi.org/10.1158/1940-6207.c.6546958.v1