Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Frank A. Simmen"'
Autor:
Melissa E. Heard-Lipsmeyer, Iad Alhallak, Frank A. Simmen, Stepan B. Melnyk, Rosalia C. M. Simmen
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Endometriosis is a chronic, estrogen-dependent gynecologic disorder that affects reproductive-aged women and to a lesser extent, post-menopausal women on hormone therapy. The condition is associated with systemic and local immune dysfunctions. While
Externí odkaz:
https://doaj.org/article/7d31c90c98c74fb7b8390db863e82a14
Autor:
Lorenzo M. Fernandes, Ahmed Al-Dwairi, Rosalia C. M. Simmen, Meera Marji, Dustin M. Brown, Sarah W. Jewell, Frank A. Simmen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of
Externí odkaz:
https://doaj.org/article/899beda0f140402686c9d2bb53f53cc2
Autor:
Frank A. Simmen, John Mark P. Pabona, Ahmed Al-Dwairi, Iad Alhallak, Maria Theresa E. Montales, Rosalia C. M. Simmen
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6613
Malic Enzyme 1 (ME1) supports lipogenesis, cholesterol synthesis, and cellular redox potential by catalyzing the decarboxylation of L-malate to pyruvate, and the concomitant reduction of NADP to NADPH. We examined the contribution of ME1 to the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70cf6e781a6c18daa021490682d4dc
Autor:
Lin-Xi Li, Rosalia C. M. Simmen, Stacy A Petty, Keith G. Wolter, Iad Alhallak, Frank A. Simmen, Richard J Ward, Ana Castro Munoz
Publikováno v:
J Mol Endocrinol
Epidemiological studies inversely associate BMI with breast cancer risk in premenopausal women, but the pathophysiological linkage remains ill-defined. Despite the documented relevance of the ‘local’ environment to breast cancer progression and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7d4739907561bd349bbeb3779ddab9
https://doi.org/10.1530/jme-21-0100
https://doi.org/10.1530/jme-21-0100
Publikováno v:
Environ Sci Process Impacts
Trichloroethylene (TCE) is an environmental contaminant associated with immune-mediated inflammatory disorders and neurotoxicity. Based on known negative effects of developmental overnutrition on neurodevelopment, we hypothesized that developmental e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0530924be2dc2e912776352abf9a0fdc
https://doi.org/10.1039/c9em00514e
https://doi.org/10.1039/c9em00514e
Autor:
Shi J Liu, Frank A. Simmen, Dustin M. Brown, Eric R. Siegel, Alexander F. Burnett, Iad Alhallak, John Mark P. Pabona, Tyler Rose, Maria Theresa E. Montales, Rosalia C. M. Simmen, Charles M. Quick
Publikováno v:
Reproductive Sciences
Metformin (MET) is increasingly implicated in reducing the incidence of multiple cancer types in patients with diabetes. However, similar effects of MET in non-diabetic women with endometrial cancer (EC) remain unknown. In a pilot study, obese non-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a350265e001b8153a6bf24ee965ca6
http://europepmc.org/articles/PMC7077930
http://europepmc.org/articles/PMC7077930
Autor:
Adam R. Brown, Iad Alhallak, Rosalia C. M. Simmen, Stepan B. Melnyk, Melissa E. Heard-Lipsmeyer, Maria Theresa E. Montales, Daniel Habenicht, Trang T. Van, Frank A. Simmen
Publikováno v:
Cancers; Volume 14; Issue 7; Pages: 1737
Obesity, oxidative stress, and inflammation are risk factors for hepatocellular carcinoma (HCC). We examined, in mice, the effects of Krüppel-like factor 9 (KLF9) knockout on: adiposity, hepatic and systemic oxidative stress, and hepatic expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065726639fe2a0c3cfe627b2a38a9fe4
https://pubmed.ncbi.nlm.nih.gov/35406507
https://pubmed.ncbi.nlm.nih.gov/35406507
Autor:
Ahmed Al-Dwairi, Adam R Brown, John Mark P Pabona, Trang H Van, Hamdan Hamdan, Charles P Mercado, Charles M Quick, Patricia A Wight, Rosalia C M Simmen, Frank A Simmen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113058 (2014)
The small intestine participates in lipid digestion, metabolism and transport. Cytosolic malic enzyme 1 (ME1) is an enzyme that generates NADPH used in fatty acid and cholesterol biosynthesis. Previous work has correlated liver and adipose ME1 expres
Externí odkaz:
https://doaj.org/article/8b6b042edb714e438b1b26e489d96330
Publikováno v:
J Mol Endocrinol
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690e4512d5d743da2ba84219d7f4b3f5
https://pubmed.ncbi.nlm.nih.gov/33064660
https://pubmed.ncbi.nlm.nih.gov/33064660
Autor:
Frank A. Simmen, Iad Alhallak, Rosalia C. M. Simmen, Keith G Wolter, Stacy A Petty, Richard Jon Ward
Publikováno v:
Journal of the Endocrine Society
Obesity is a major risk factor for many chronic diseases including postmenopausal breast cancer. Paradoxically, breast cancer susceptibility is inversely linked to obesity in pre-menopausal women. Adipose tissues are active endocrine organs that play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82a62da4aeaadbe8a07bfdc07f93e8b
https://doi.org/10.1210/jendso/bvaa046.143
https://doi.org/10.1210/jendso/bvaa046.143