Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Frank A. Horrigan"'
Autor:
Michael D. Kim, Samuel Chung, Nathalie Baumlin, Liang Sun, Neerupma Silswal, John S. Dennis, Makoto Yoshida, Juan Sabater, Frank T. Horrigan, Matthias Salathe
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L468-L479
Propylene glycol (PG) is a common delivery vehicle for nicotine and flavorings in e-cigarette (e-cig) liquids and is largely considered safe for ingestion. However, little is known about its effects as an e-cig aerosol on the airway. Here, we investi
Autor:
Xiaolei Wang, Jia Song, Yue Yuan, Luge Li, Issam Abu-Taha, Jordi Heijman, Liang Sun, Shokoufeh Dobrev, Markus Kamler, Liang Xie, Xander H.T. Wehrens, Frank T. Horrigan, Dobromir Dobrev, Na Li
Publikováno v:
Circulation Research.
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the function of FKBP5 in the heart remains unknown. Here, we elucidate the consequen
Autor:
Stephanie L. LeValley, Markus Kalkum, Frank T. Horrigan, Robert A. Britton, Daniel Röth, Catherine Tomaro-Duchesneau, Liang Sun, Joseph M. Hyser
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Early work in germ-free rodents highlighted the gut microbiota’s importance in metabolic disease, including Type II Diabetes Mellitus (T2DM) and obesity. Glucagon-like peptide-1 (GLP-1) is an incretin secreted by enteroendocrine L-cells lining the
Autor:
Sebastian F. Salathe, Nathalie Baumlin, Philip L. Whitney, Juan R. Sabater, Matthias Salathe, Michael D. Kim, Adam Wanner, Frank T. Horrigan, Juliette Sailland, William M. Abraham, John Dennis, Deepika Polineni, Joseph K. David, Charles A. Peloquin, Makoto Yoshida
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:313-324
Rationale: Despite therapeutic progress in treating cystic fibrosis (CF) airway disease, airway inflammation with associated mucociliary dysfunction remains largely unaddressed. Inflammation reduces the activity of apically expressed large-conductanc
Publikováno v:
Biophysical Journal. 116:104a
Publikováno v:
Biophysical Journal. 116:248a
Autor:
Frank T. Horrigan
Publikováno v:
Journal of General Physiology. 140:625-634
Large conductance calcium- and voltage-dependent BK potassium channels (aka BKCa, MaxiK, Slo1, KCa1.1, and KCNMA1) are expressed in a wide variety of tissues throughout the body and are activated by both intracellular Ca2+ and membrane depolarization
Publikováno v:
Proceedings of the National Academy of Sciences. 104:18270-18275
The voltage-sensor domain (VSD) of voltage-dependent ion channels and enzymes is critical for cellular responses to membrane potential. The VSD can also be regulated by interaction with intracellular proteins and ligands, but how this occurs is poorl
Autor:
Guangping Zhang, Frank T. Horrigan
Publikováno v:
The Journal of General Physiology
The Ca2+-activated K+ (BK) channel α-subunit contains many cysteine residues within its large COOH-terminal tail domain. To probe the function of this domain, we examined effects of cysteine-modifying reagents on channel gating. Application of MTSET
Autor:
Guangping Zhang, Zhongming Ma, Frank T. Horrigan, Gayathri Krishnamoorthy, Fred H. Sieling, Jingyi Shi, Lei Hu, Jianmin Cui
Publikováno v:
Proceedings of the National Academy of Sciences. 100:10488-10493
The S4 transmembrane segment is the primary voltage sensor in voltage-dependent ion channels. Its movement in response to changes in membrane potential leads to the opening of the activation gate, which is formed by a separate structural component, t