Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Frank A. Fitzpatrick"'
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13545 (2010)
PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism. Adaptation of a redox-sensitive cysteinyl thiol in PTEN for signal transduction by hydrogen peroxide may have sup
Externí odkaz:
https://doaj.org/article/a60878cab3fd4c3a89365b9924f555e7
Autor:
David M. Burnett, Amanda Alexander, Margaret Yu, Wolfram E. Samlowski, Mazin A. Al-Salihi, Frank A. Fitzpatrick
Publikováno v:
Scopus-Elsevier
5-Aza-2'-deoxycytidine (decitabine) is a drug targeting the epigenetic abnormalities of tumors. The basis for its limited efficacy in solid tumors is unresolved, but may relate to their indolent growth, their p53 genotype or both. We report that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef781a943060bdaba6f9b833adc0ed4b
https://doi.org/10.4161/epi.6.8.16064
https://doi.org/10.4161/epi.6.8.16064
Publikováno v:
Journal of Biological Chemistry. 282:32623-32629
Human peroxiredoxins serve dual roles as anti-oxidants and regulators of H2O2-mediated cell signaling. The functional versatility of peroxiredoxins depends on progressive oxidation of key cysteine residues. The sulfinic or sulfonic forms of peroxired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c671d286ed77a2c114151d017acc0e61
https://doi.org/10.1074/jbc.m704369200
https://doi.org/10.1074/jbc.m704369200
Autor:
Pamela B. Cassidy, Philip J. Moos, Chad C. Nelson, Frank A. Fitzpatrick, Kornelia Edes, Krishna Parsawar
Publikováno v:
Carcinogenesis. 27:2538-2549
Previous studies demonstrate that the covalent modification of thioredoxin reductase (TrxR) by both endogenous and exogenous electrophiles results in disruption of the conformation of the tumor suppressor protein p53. Here we report that the loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184e3ea1a7d27d29d38eceb6428d91e2
https://doi.org/10.1093/carcin/bgl111
https://doi.org/10.1093/carcin/bgl111
Publikováno v:
Journal of Biological Chemistry. 281:2598-2604
LKB1, a unique serine/threonine kinase tumor suppressor, modulates anabolic and catabolic homeostasis, cell proliferation, and organ polarity. Chemically reactive lipids, e.g. cyclopentenone prostaglandins, formed a covalent adduct with LKB1 in MCF-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5c9d26b7036256213fa42d8ff47d7c6
https://doi.org/10.1074/jbc.m509723200
https://doi.org/10.1074/jbc.m509723200
Autor:
Kenneth M. Boucher, David A. Jones, Pamela B. Cassidy, Patricia Porter-Gill, Wolfram E. Samlowski, Mark Wade, Frank A. Fitzpatrick, Richard H. Wheeler, Adam R. Karpf, Sancy A. Leachman, Leslie T. Busby
Publikováno v:
Journal of Clinical Oncology. 23:3897-3905
Purpose The nucleoside analog 5-aza-2′-deoxycytidine (5-aza-CdR, decitabine) is a potent inhibitor of DNA methylation in vitro. Cellular treatment with this agent induces the re-expression of methylation-silenced genes. It remains unclear to what e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc4e354dfe99e6a0d0aac82841d04cf
https://doi.org/10.1200/jco.2005.06.118
https://doi.org/10.1200/jco.2005.06.118
Publikováno v:
Journal of Biological Chemistry. 279:28028-28035
The selenoenzyme thioredoxin reductase regulates redox-sensitive proteins involved in inflammation and carcinogenesis, including ribonucleotide reductase, p53, NFκB, and others. Little is known about endogenous cellular factors that modulate thiored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed2a3ee6eb0dd46f3286245ac071566
https://doi.org/10.1074/jbc.m313939200
https://doi.org/10.1074/jbc.m313939200
Publikováno v:
Journal of Biological Chemistry. 276:30366-30373
Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated alpha,beta-unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner analogous to prostaglandins of the A series. Like the prostaglandins o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12651b8fe058b8c8e142aaecf82c932
https://doi.org/10.1074/jbc.m102198200
https://doi.org/10.1074/jbc.m102198200
Autor:
Frank A. Fitzpatrick, Robert A. Lepley
Publikováno v:
Archives of Biochemistry and Biophysics. 356:71-76
A region of basic amino acids spanning residues 639-656 in the human 5-lipoxygenase sequence resembles a consensus bipartite nuclear localizing sequence. A synthetic peptide consisting of the Kaposi fibroblast growth factor signal sequence fused to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f5f81eee8d8a258a76dde003233eb
https://doi.org/10.1006/abbi.1998.0744
https://doi.org/10.1006/abbi.1998.0744
Autor:
Frank A. Fitzpatrick, Robert A. Lepley
Publikováno v:
Archives of Biochemistry and Biophysics. 331:141-144
In Ca2+ ionophore-activated HL-60 granulocytes the mitogen-activated protein kinase kinase-1 inhibitor, PD098059, blocked translocation of 5-lipoxygenase from the cytosol to the nuclear membrane and the corresponding enzyme activation. PD098059 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcd62622c8c39b19c7e69d2eee63ed5
https://doi.org/10.1006/abbi.1996.0292
https://doi.org/10.1006/abbi.1996.0292