Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Frank A. Duca"'
Autor:
Taylor M. Martinez, Hallie R. Wachsmuth, Rachel K. Meyer, Savanna N. Weninger, Adelina I. Lane, Archana Kangath, Gabriele Schiro, Daniel Laubitz, Jennifer H. Stern, Frank A. Duca
Publikováno v:
Nutrition & Metabolism, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background The gut microbiome is a salient contributor to the development of obesity, and diet is the greatest modifier of the gut microbiome, which highlights the need to better understand how specific diets alter the gut microbiota to impa
Externí odkaz:
https://doaj.org/article/3c058da9c52d406fae9ccc5d926f798b
Autor:
Savanna N. Weninger, Chloe Herman, Rachel K. Meyer, Eve T. Beauchemin, Archana Kangath, Adelina I. Lane, Taylor M. Martinez, Tahia Hasneen, Sierra A. Jaramillo, Jason Lindsey, Gayatri Vedantam, Haijiang Cai, Emily K. Cope, J. Gregory Caporaso, Frank A. Duca
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Background Upper small intestinal dietary lipids activate a gut-brain axis regulating energy homeostasis. The prebiotic, oligofructose (OFS) improves body weight and adiposity during metabolic dysregulation but the exact mechanisms remain un
Externí odkaz:
https://doaj.org/article/b5f6a5e76ea84f92a3f3d295a21f0069
Autor:
Savanna N. Weninger, Angela Ding, Elizabeth N. Browne, Morgan L. Frost, Gabriele Schiro, Daniel Laubitz, Frank A. Duca
Publikováno v:
Metabolites, Vol 13, Iss 5, p 660 (2023)
The complex development of type 2 diabetes (T2D) creates challenges for studying the progression and treatment of the disease in animal models. A newly developed rat model of diabetes, the Zucker Diabetic Sprague Dawley (ZDSD) rat, closely parallels
Externí odkaz:
https://doaj.org/article/5a2ea1d04c3a44bf86bb51f76fefc9f7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The gastrointestinal tract participates in maintaining metabolic homeostasis in part through nutrient-sensing and subsequent gut-brain signalling. Here the authors review the role of small intestinal nutrient-sensing in regulation of energy intake an
Externí odkaz:
https://doaj.org/article/a95c8ae22f0042f1b3ef962d4051972d
Autor:
Caroline E. Geisler, Susma Ghimire, Stephanie M. Bruggink, Kendra E. Miller, Savanna N. Weninger, Jason M. Kronenfeld, Jun Yoshino, Samuel Klein, Frank A. Duca, Benjamin J. Renquist
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109301- (2021)
Summary: Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To as
Externí odkaz:
https://doaj.org/article/4b2355ca544d494dbd7dc0fa2939ed72
Autor:
T. M. Zaved Waise, Mozhgan Rasti, Frank A. Duca, Song-Yang Zhang, Paige V. Bauer, Christopher J. Rhodes, Tony K. T. Lam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin (TOR) functions as an energy sensor and contributes to the control of glucose homeostasis. Here, the authors show that mTOR in the upper small intestine regulates hepatic glucose production and is required for the
Externí odkaz:
https://doaj.org/article/ed627460bddc4b5ba603759563251b83
Autor:
Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan, Tony K. T. Lam
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic h
Externí odkaz:
https://doaj.org/article/39518d1b32d94bf387969a5e946ba9b7
Autor:
Emily C. Peters, Luke Safayan, Tyler J. Marx, Emily Ngu, Anastasiia Vasileva, India Zappia, William H. Powell, Frank A. Duca, Jennifer H. Stern
Publikováno v:
Biogerontology. 23:741-755
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30–40% calorie restriction to investigate these benefits. The goal of our study was to investigate the effects of calor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adea3dd4b33905658c7c655d1fb13cbf
https://doi.org/10.1007/s10522-022-09996-5
https://doi.org/10.1007/s10522-022-09996-5
Autor:
Rachel Katherine Meyer, Frank A Duca
Publikováno v:
Journal of Endocrinology.
The gastrointestinal system is now considered the largest endocrine organ, highlighting the importance of gut-derived peptides and metabolites in metabolic homeostasis. Gut peptides are secreted from intestinal enteroendocrine cells in response to nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3181f66435b10c7cbec9634da267d1a0
https://doi.org/10.1530/joe-23-0019
https://doi.org/10.1530/joe-23-0019
Publikováno v:
Experimental & Molecular Medicine. 54:377-392
The gastrointestinal tract plays a role in the development and treatment of metabolic diseases. During a meal, the gut provides crucial information to the brain regarding incoming nutrients to allow proper maintenance of energy and glucose homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29a3fbb5cde4965fd1c1cce047fab58
https://doi.org/10.1038/s12276-021-00677-w
https://doi.org/10.1038/s12276-021-00677-w