Zobrazeno 1 - 10
of 1 041
pro vyhledávání: '"Frank Tacke"'
Autor:
Miriam Hägele, Johannes Eschrich, Lukas Ruff, Maximilian Alber, Simon Schallenberg, Adrien Guillot, Christoph Roderburg, Frank Tacke, Frederick Klauschen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In this paper we present a deep learning segmentation approach to classify and quantify the two most prevalent primary liver cancers – hepatocellular carcinoma and intrahepatic cholangiocarcinoma – from hematoxylin and eosin (H&E) staine
Externí odkaz:
https://doaj.org/article/d08e9148e45f44629cc40f3db86efa21
Autor:
Sylvia M. Brakenhoff, Thymen Theijse, Peter van Wijngaarden, Christian Trautwein, Jonathan F. Brozat, Frank Tacke, Pieter Honkoop, Thomas Vanwolleghem, Dirk Posthouwer, Stefan Zeuzem, Ulrike Mihm, Heiner Wedemeyer, Thomas Berg, Solko W. Schalm, Robert J. de Knegt
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background and Aims Systematic reviews and medical guidelines are widely used in clinical practice. However, these are often not up-to-date and focussed on the average patient. We therefore aimed to evaluate a guideline add-on, TherapySelect
Externí odkaz:
https://doaj.org/article/c576f08441324371baa5a462203e8cd0
Autor:
Can Kamali, Philipp Brunnbauer, Kaan Kamali, Al-Hussein Ahmed Saqr, Alexander Arnold, Gulcin Harman Kamali, Julia Babigian, Eriselda Keshi, Raphael Mohr, Matthäus Felsenstein, Simon Moosburner, Karl-Herbert Hillebrandt, Jasmin Bartels, Igor Maximilian Sauer, Frank Tacke, Moritz Schmelzle, Johann Pratschke, Felix Krenzien
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Liver fibrosis progressing to cirrhosis is a major risk factor for liver cancer, impacting surgical treatment and survival. Our study focuses on the role of extracellular nicotinamide adenine dinucleotide (eNAD+) in liver fibrosis, analyzing
Externí odkaz:
https://doaj.org/article/ac5cefb1237e4ca48bf1eab5058ca5bd
Autor:
Elena Sena, Frank Tacke, Quentin M. Anstee, Nicholas Di Prospero, Mette Skalshøi- Kjær, Sergio Muñoz-Martínez, Jesús Rivera-Esteban, Alba Jiménez-Masip, Jesús M. Bañales, María Martínez-Gómez, Franz Koenig, Joan Genescà, Vlad Ratziu, Juan M. Pericàs
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-8 (2024)
Abstract Background The EU Patient-cEntric clinicAl tRial pLatforms (EU-PEARL) project (IMI2-853966) aimed to develop tools to establish integrated research platforms (IRP) for conducting adaptive-design trials in various diseases, including metaboli
Externí odkaz:
https://doaj.org/article/56b347d335b94f00aa100ba39c9f7709
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Hepatocellular carcinoma (HCC) poses a significant clinical challenge, necessitating the integration of immunotherapeutic approaches. Palbociclib, a selective CDK4/6 inhibitor, has demonstrated promising efficacy in preclinical HCC models an
Externí odkaz:
https://doaj.org/article/98910cd9e30942b5a5cfac1927fa60df
Autor:
Andreas Göhrig, Georg Hilfenhaus, Friederike Rosseck, Martina Welzel, Benjamin Moser, Gianluca Barbone, Catarina Alisa Kunze, Johannes Rein, Gregor Wilken, Michael Böhmig, Thomas Malinka, Frank Tacke, Marcus Bahra, Katharina M. Detjen, Christian Fischer
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background Surgery represents the only curative treatment option for pancreatic ductal adenocarcinoma (PDAC), but recurrence in more than 85% of patients limits the success of curative-intent tumor resection. Neural invasion (NI), particular
Externí odkaz:
https://doaj.org/article/44afbf779418478c978dd8d20a1cf953
Autor:
Hanyang Liu, Guo Yin, Marlene Sophia Kohlhepp, Fabian Schumacher, Jana Hundertmark, Mohamed I. Abdelwahab Hassan, Felix Heymann, Tobias Puengel, Burkhard Kleuser, Alexander Sandy Mosig, Frank Tacke, Adrien Guillot
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is hallmarked by hepatic steatosis, cell injury, inflammation, and fibrosis. This study elaborates on a multicellular biochip‐based liver sinusoid model to mimic MASLD path
Externí odkaz:
https://doaj.org/article/9272a9bbb3c4464797bd2b110a66e0f0
Autor:
Oliver Schnell, Katharine Barnard-Kelly, Tadej Battelino, Antonio Ceriello, Helena Elding Larsson, Beatriz Fernández-Fernández, Thomas Forst, Juan-Pablo Frias, James R. Gavin, Francesco Giorgino, Per-Henrik Groop, Hiddo J. L. Heerspink, Stephan Herzig, Michael Hummel, George Huntley, Mahmoud Ibrahim, Baruch Itzhak, Stephan Jacob, Linong Ji, Mikhail Kosiborod, Nebosja Lalic, Sofia Macieira, Rayaz A. Malik, Boris Mankovsky, Nikolaus Marx, Chantal Mathieu, Timo D. Müller, Kausik Ray, Helena W. Rodbard, Peter Rossing, Lars Rydén, Petra-Maria Schumm-Draeger, Peter Schwarz, Jan Škrha, Frank Snoek, Frank Tacke, Bruce Taylor, Britta Tendal Jeppesen, Solomon Tesfaye, Pinar Topsever, Tina Vilsbøll, Xuefeng Yu, Eberhard Standl
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exch
Externí odkaz:
https://doaj.org/article/167ffccba8024cf1934fce0e0b20bdf0
Autor:
Anjana Singh, Adriaan O. Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C. A. de Jager, Ilze Bot, Sergei P. Atamas, Theo J. C. van Berkel, J. Wouter Jukema, Iain Comerford, Shaun R. McColl, Barend Mees, Johan W. M. Heemskerk, Gerry A. F. Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the r
Externí odkaz:
https://doaj.org/article/573017efcc53412a84624e171b71058e
Autor:
Sven H. Loosen, Fabian Benz, Raphael Mohr, Philipp A. Reuken, Theresa H. Wirtz, Lioba Junker, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Alexander Wree, Johanna Reißing, Münevver Demir, Wenyi Gu, Mihael Vucur, Robert Schierwagen, Andreas Stallmach, Anselm Kunstein, Johannes Bode, Christian Trautwein, Frank Tacke, Tom Luedde, Tony Bruns, Jonel Trebicka, Christoph Roderburg
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101054- (2024)
Background & Aims: Transjugular intrahepatic portosystemic shunt (TIPS) is the most effective therapy for complications of portal hypertension. However, clinical outcomes following TIPS placement vary widely between patients and identifying ideal can
Externí odkaz:
https://doaj.org/article/1c0266d113654c7496f7e96b4601da0f