Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Frank J. Urban"'
Autor:
Kathleen S. Zandi, William Kissel, Brian M. Andresen, Chiu Charles K, John Charles Kath, David C. Whritenour, Matthew Frank Brown, Tung Le, Z. Jane Li, Eric Dias, Richard A. Buzon, Michel Couturier, Bryan Li, John L. Tucker, V. John Jasys, Joanna Teresa Negri, Poss Christopher Stanley, Frank J. Urban
Publikováno v:
Organic Process Research & Development. 9:466-471
Process development for the synthesis of 2-quinoxalinecarboxamide, N-[(1S,2S,4R)-4-(aminocarbonyl)-1-[(3-fluorophenyl)methyl]-2,7-dihydroxy-7-methyloctyl] is described. An optimized and streamlined process starting from lactone 2 was developed: Lacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfdf67bd0fea0a89f37efcd9381a33b
https://doi.org/10.1021/op050059w
https://doi.org/10.1021/op050059w
Autor:
Enrique Vazquez, Susan Deborah Lagreca, Mark Guinn, Michel Couturier, Marcus Ewing, Karl Ng, A. Morgan Stewart, Lulin Wei, Raggon Jeffrey W, Brian M. Andresen, John L. Tucker, V. John Jasys, Frank J. Urban, Garrett Moraski, Derek L. Tickner, Joel M. Hawkins, B. J. Cronin, Joseph Peter Lyssikatos, Michael D'occhio
Publikováno v:
Organic Process Research & Development. 8:643-650
As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62f35f47fd9303eb09dc350ab597f78f
https://doi.org/10.1021/op049935g
https://doi.org/10.1021/op049935g
Autor:
Devries Keith Michael, Frank J. Urban, Michael W. Snyder, Brian C. Vanderplas, Raggon Jeffrey W, Fox Darrell E
Publikováno v:
Organic Process Research & Development. 8:583-586
A scaleable synthesis of the β-3 adrenergic receptor agonist, (4-{2-[2-(6-aminopyridin-3-yl)-(2R)-hydroxy-ethylamino]ethoxy}phenyl)acetic acid is presented. The key coupling step utilizes a silyl-p...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f9a3a675b0283cd924875d53aea249
https://doi.org/10.1021/op049969o
https://doi.org/10.1021/op049969o
Autor:
Frank J. Urban, V. John Jasys
Publikováno v:
Organic Process Research & Development. 8:169-175
Two processes for the preparation of lactone [2S-(3-fluorophenyl)-1S-(5-oxotetrahydrofuran-2-yl)ethyl]carbamic acid tert-butyl ester 1 starting from S-BOC-(3-fluorophenyl)alanine 3 are described. (S)-(3-Fluorophenyl)alanine N-methyl-N-methoxy amide 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9b5e9c4010c83a9b8deb760b0350d75
https://doi.org/10.1021/op030207n
https://doi.org/10.1021/op030207n
Autor:
John D. Weaver, Richard A. Buzon, Raggon Jeffrey W, James F. Eggler, Paul D. Hill, V. John Jasys, Frank J. Urban
Publikováno v:
Synthetic Communications. 33:2029-2043
A novel synthesis of the anti-inflammatory agent 1-(1,2,3,5,6,7- hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl] urea 1 is described. Sulfonamide 5 was prepared starting from ethyl 3-furoate 2. Key steps were a one-pot sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b35460ac9fada93ff99a5abe82176a
https://doi.org/10.1081/scc-120021029
https://doi.org/10.1081/scc-120021029
Publikováno v:
Organic Process Research & Development, 5(6), 575-580. American Chemical Society
An efficient synthesis of the PDE IV inhibitor, 9H-cyclopentyl-7-ethyl-3-(thiophen-2-yl)-pyrazolo[3,4-c]-1,2,4-triazolo-5,6-dihydro-[4,3-a]pyridine 1 is described. Starting from commercially available γ-caprolactone, the synthesis was carried out in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238146dfb20b97b091e461a89a267286
https://doi.org/10.1021/op010222x
https://doi.org/10.1021/op010222x
Publikováno v:
Organic Process Research & Development. 3:460-464
Two syntheses of the novel CNS agent, 2-fluoro-4-(trans)-(4-(3‘H-spiro[cyclohex-1,1‘-isobenzofuran]-4-yl)-piperazin-1-yl)-benzonitrile, 1, are presented. The first relied on a reductive alkylation with low regioselectivity (1:1) but was sufficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c98d40d44b8b0f5e235619b91f89ef
https://doi.org/10.1021/op990191u
https://doi.org/10.1021/op990191u
Autor:
Frank J. Urban, Ralph Breitenbach
Publikováno v:
Synthetic Communications. 29:645-653
A synthesis of 6-nitro and 6-amino 2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolines using a bis-alkylation process is described. 5-(Aminomethyl)-1-(p-methoxybenzyl)-triazole was prepared by a regioselective route from 1,2,4-triazole.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb1b2c10947545eb1b2d7398bfe6b7f
https://doi.org/10.1080/00397919908085813
https://doi.org/10.1080/00397919908085813
Publikováno v:
The Journal of Organic Chemistry. 63:4116-4119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14da76bedb12650b3d3fac76c152385e
https://doi.org/10.1021/jo972184e
https://doi.org/10.1021/jo972184e
Autor:
Peter J. Daniels, Sally Gut, Peter J. Dunn, and Susan L. Orrill, Ralph Breitenbach, Richard A. Buzon, Lehner Richard S, Frank J. Urban, Jr.† Harry A. Watson
Publikováno v:
Organic Process Research & Development. 2:66-70
This paper describes process research leading to the successful scale-up of a potent cholesterol absorption inhibitor 4‘‘,6‘‘-bis((2-fluorophenyl)carbamoyl)hecogenyl β-O-cellobioside 3. The synthesis of 3 from hecogenyl β-O-cellobioside 4 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7dc2d73ccff1d378a6f220b69536c0
https://doi.org/10.1021/op9702206
https://doi.org/10.1021/op9702206