Výsledky vyhledávání - "Frank, Toner"

Support for Regulatory Assessment of Percutaneous Absorption of Retronecine-type Pyrrolizidine Alkaloids through Human Skin

Autor: Clive Roper, Alberto Plaza, James A. Harris, Peter Ottersbach, Frank Toner, Catherine Mahony

Publikováno v: Planta Medica. 88:144-151

1,2-unsaturated pyrrolizidine alkaloids are found naturally in Symphytum officinale, well known as comfrey, which has a longstanding use for the topical treatment of painful muscle and joint complaints. Pyrrolizidine alkaloids (PA) are a relevant con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b9bf35eeea3ac5062802454ee598a9
https://doi.org/10.1055/a-1505-8524

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Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs

Autor: Joanna Hummer, Thomas Birngruber, Frank Sinner, Leanne Page, Frank Toner, Clive S. Roper, David J. Moore, Mark B. Baker, Mila Boncheva Bettex

Publikováno v: International journal of pharmaceutics. 620

This paper describes a new approach to the early-stage optimization of topical products and selection of lead formulation candidates. It demonstrates the application of open flow microperfusion in vitro in conjunction with the Franz diffusion cell to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25ba4526ef55c2e9b192c1b95fd65ef
https://pubmed.ncbi.nlm.nih.gov/35413396

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Comparison of In Vitro and In Vivo Percutaneous Absorption Across Human Skin Using BAY1003803 Formulated as Ointment and Cream

Autor: Alen Jambrecina, Timm Schmidt, Frank Toner, Rüdiger Nave, Kristin Kowal, Clemens Günther

Publikováno v: Clinical Pharmacology in Drug Development

Direct comparisons between skin absorption data and clinical pharmacokinetic data are rare. Here we use the lipophilic nonsteroidal selective glucocorticoid receptor agonist BAY1003803 to make such a comparison. The objective is to find the extent to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1bd196763c80c7a49f341d42521a11
http://europepmc.org/articles/PMC7383986

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Use of an in vitro human skin permeation assay to assess bioequivalence of two topical cream formulations containing butenafine hydrochloride (1%, w/w)

Autor: Susan Craig, Clive Roper, Thomas A. Meyer, Frank Toner, Nanhye Kim, Amitava Mitra, Darren Spark

Publikováno v: Regulatory Toxicology and Pharmacology. 82:14-19

The primary objective of this work was to investigate, using an in vitro human skin permeation study, whether changes in the excipients of butenafine hydrochloride cream would have any effect on bioperformance of the formulation. Such in vitro data w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6721fd0691339ab3deae91d43e8db0
https://doi.org/10.1016/j.yrtph.2016.11.008

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Multi-laboratory evaluation of SkinEthic HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemicals testing

Autor: Nathalie Alépée, Marie-Hélène Grandidier, L. Nardelli, Marisa Meloni, C J Vinall, Virginie Leblanc, A.R. Van Rompay, Els Adriaens, Frank Toner, Clive Roper, José Cotovio

Publikováno v: Toxicology in Vitro. 34:55-70

A prospective multicentre study of the reconstructed human corneal epithelial tissue-based in vitro test method (SkinEthic™ HCE) was conducted to evaluate its usefulness to identify chemicals as either not classified for serious eye damage/eye irri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bd1298308e8299afecbf99bc345b42
https://doi.org/10.1016/j.tiv.2016.02.014

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Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone

Autor: Carsten Goebel, Cindy A. Ryan, Frank Toner, Clive Roper, Petra S. Kern, Leanne Page, Joanne Vinall, Helga Rothe, Heike Scheffler

Publikováno v: Regulatory toxicology and pharmacology : RTP. 91

Use of quantitative risk assessment (QRA) for assessing the skin sensitization potential of chemicals present in consumer products requires an understanding of hazard and product exposure. In the absence of data, consumer exposure is based on relevan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5911ad279c3654deb12dbab9c9b44f32
https://pubmed.ncbi.nlm.nih.gov/29080845

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An in vitro Skin Penetration Model for Compromised Skin: Estimating Penetration of Polyethylene Glycol [14C]-PEG-7 Phosphate

Autor: Frank Toner, Leanne Page, Swatee Dey, Robert O’Connor, Ken Wehmeyer, Helga Rothe, Shaoying Zhou, Sara Farahmand, Randy Marsh

Publikováno v: Skin Pharmacology and Physiology. 28:12-21

Background/Aims: Establishing dermal penetration rates is important to better understand the safety of topically applied materials, especially for premature infant skin with compromised skin barrier function. Skin prematurity involves thinner stratum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e10fc4e8ee28545675926f9f3d72102
https://doi.org/10.1159/000362284

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