Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Autor: Christina Reith, Colin Baigent, Lisa Blackwell, Jonathan Emberson, Enti Spata, Kelly Davies, Heather Halls, Lisa Holland, Kate Wilson, Jane Armitage, Charlie Harper, David Preiss, Alistair Roddick, Anthony Keech, John Simes, Rory Collins, Elizabeth Barnes, Jordan Fulcher, William G Herrington, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, Pierre Amarenco, Philip Barter, D John Betteridge (deceased), Michael Blazing, Jackie Bosch, Louise Bowman, Eugene Braunwald, Christopher P Cannon, Michael Clearfield, Stuart Cobbe, Helen M Colhoun, Björn Dahlöf, Barry Davis, James de Lemos, John R Downs, Paul N Durrington, Bengt Fellström, Ian Ford, Maria Grazia Franzosi, John Fuller (deceased), Curt Furberg, Robert Glynn, David Gordon, Antonio Gotto Jr, Richard Grimm, Ajay Gupta, C Morton Hawkins, Graham A Hitman, Hallvard Holdaas (deceased), Alan Jardine, J Wouter Jukema, John JP Kastelein, Sharon Kean, John Kjekshus, Genell Knatterud (deceased), Robert H Knopp (deceased), Wolfgang Koenig, Michael Koren, Vera Krane, Martin Landray, John LaRosa, Roberto Latini, Eva Lonn, Donata Lucci, Jean MacFadyen, Peter Macfarlane, Stephen MacMahon, Aldo Maggioni, Roberto Marchioli, Ian Marschner, Lemuel Moyé, Sabina Murphy, Andrew Neil, Enrico B Nicolis, Chris Packard, Sarah Parish, Terje R Pedersen, Richard Peto, Marc Pfeffer, Neil Poulter, Sara Pressel, Jeffrey Probstfield, Mahboob Rahman, Paul M Ridker, Michele Robertson, Frank Sacks, Naveed Sattar, Roland Schmieder, Patrick W Serruys, Peter Sever, John Shaw (deceased), James Shepherd (deceased), Lara Simpson, Peter Sleight (deceased), Luigi Tavazzi, Gianni Tognoni, Andrew Tonkin, Stella Trompet, Christoph Wanner, Hans Wedel, Stephen Weis, K Michael Welch, Harvey White, John Wikstrand, Lars Wilhelmsen, Stephen Wiviott, Robin Young, Salim Yusuf, Faiez Zannad, Hiroyuki Arashi, Robert Byington, Robert Clarke, Marcus Flather, Uri Goldbourt, Shinya Goto, Jemma Hopewell, Kees Hovingh, Patricia Kearney, George Kitas, Connie Newman, Marc S Sabatine, Greg Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamaguchi

Publikováno v: The Lancet, 400(10355), 832-845. Elsevier Limited

Background: Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4616cab962081ebdd901d4a6e1652a20
https://pure.amc.nl/en/publications/effect-of-statin-therapy-on-muscle-symptoms(c31d56e2-803e-4f3b-881a-6f09bfa1f0f4).html

553-P: Changes in Circulating Bile Acids and the Improvements in Glucose and Insulin Metabolism in Response to Weight-Loss Diets: The POUNDS Lost Trial

Autor: YORIKO HEIANZA, XUAN WANG, HAO MA, JENNIFER ROOD, CLARY B. CLISH, GEORGE BRAY, FRANK SACKS, LU QI

Publikováno v: Diabetes. 71

Bile acids (BAs) are synthesized from cholesterol in the liver and are essential for nutrient absorption. The host-derived primary BAs are transformed into secondary BAs in the intestine. Various BA subtypes may play pivotal roles as endocrine molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::507845ffa3cc7b6801938d0922232444
https://doi.org/10.2337/db22-553-p

1410-P: Changes in Circulating MicroRNA-193b and Long-Term Successful Weight Loss in Response to Dietary and Lifestyle Interventions: The POUNDS Lost and CENTRAL Trials

Autor: YORIKO HEIANZA, QIAOCHU XUE, JENNIFER ROOD, KNUT K. KROHN, ANAT YASKOLKA MEIR, MATTHIAS BLÜHER, PETER KOVACS, IRIS SHAI, GEORGE BRAY, FRANK SACKS, LU QI

Publikováno v: Diabetes. 71

Circulating microRNAs (miRNAs) have been implicated in controlling whole-body metabolism through intercellular communications. MicroRNA-193b (miR-193b) plays essential roles in white and brown adipocyte adipogenesis and regulating adipokine secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f724fc9a096ee55d047c56cab28c9be
https://doi.org/10.2337/db22-1410-p

Abstract MP30: Circulating MicroRNA-128-1 And Changes In Energy Metabolism And Insulin Sensitivity In Response To Weight Loss Diet Interventions: The Pounds Lost Trial

Autor: Yoriko Heianza, Qiaochu Xue, Jennifer Rood, George Bray, Frank Sacks, Lu Qi

Publikováno v: Circulation. 145

Background: MicroRNA (miRNAs) are short non-coding RNAs that play important roles in regulating gene expression. Recently, miR-128-1 was identified as a potential thrifty miRNA that controls energy expenditure, contributing to obesity and metabolic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6deb90c6508d91f8757a79415e97963a
https://doi.org/10.1161/circ.145.suppl_1.mp30

Abstract 10659: Blood DNA Methylation at TXNIP and Glycemic Changes in Response to Weight-Loss Diet Interventions: The POUNDS Lost Trial

Autor: Xiang Li, Xiaojian SHAO, Qiaochu Xue, Elin Grundberg, George Bray, Frank Sacks, Lu Qi

Publikováno v: Circulation. 144

Introduction: Thioredoxin Interacting Protein ( TXNIP ) functions as a master regulator for glucose homeostasis. Hypomethylation at the 5'-cytosine-phosphate-guanine-3' (CpG) site cg19693031 of TXNIP has been consistently related to islet dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c3e3c81b2093389b0b87e601b428912
https://doi.org/10.1161/circ.144.suppl_1.10659