Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Frank, Reimann"'
Autor:
Mireia Montaner, Jessica Denom, Vincent Simon, Wanqing Jiang, Marie K. Holt, Daniel I. Brierley, Claude Rouch, Ewout Foppen, Nadim Kassis, David Jarriault, Dawood Khan, Louise Eygret, Francois Mifsud, David J. Hodson, Johannes Broichhagen, Lukas Van Oudenhove, Xavier Fioramonti, Victor Gault, Daniela Cota, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne-Li, Stefan Trapp, Hirac Gurden, Christophe Magnan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells,
Externí odkaz:
https://doaj.org/article/cb3515a89fa242b4a3b002d0b2c03c19
Autor:
Jo E. Lewis, Danae Nuzzaci, Paula-Peace James-Okoro, Mireia Montaner, Elisabeth O'Flaherty, Tamana Darwish, Marito Hayashi, Stephen D. Liberles, David Hornigold, Jacqueline Naylor, David Baker, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101945- (2024)
Objective: Glucose dependent insulinotropic polypeptide (GIP) is well established as an incretin hormone, boosting glucose-dependent insulin secretion. However, whilst anorectic actions of its sister-incretin glucagon-like peptide-1 (GLP-1) are well
Externí odkaz:
https://doaj.org/article/f4e357a2899c4a37a4ab6ce977e8d82c
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionMotilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans, regulating the migratory motor complex. It is understudied at least in part due to th
Externí odkaz:
https://doaj.org/article/7a08dd0a587d436180ed385259c9be65
Autor:
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We ex
Externí odkaz:
https://doaj.org/article/98622c9a195d4352900a24be2e5b4bd3
Autor:
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell
Externí odkaz:
https://doaj.org/article/166afa66325d42c88ebcf56718483f72
Autor:
Marito Hayashi, Judith A Kaye, Ella R Douglas, Narendra R Joshi, Fiona M Gribble, Frank Reimann, Stephen D Liberles
Publikováno v:
eLife, Vol 12 (2023)
Enteroendocrine cells are specialized sensory cells of the gut-brain axis that are sparsely distributed along the intestinal epithelium. The functions of enteroendocrine cells have classically been inferred by the gut hormones they release. However,
Externí odkaz:
https://doaj.org/article/b863a0448c744108ad2ef3a271ccf20f
Autor:
Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101665- (2023)
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g
Externí odkaz:
https://doaj.org/article/a7f4d6b4357e4a4d9af68e183e845a6f
Autor:
Jo E. Lewis, Orla RM. Woodward, Danaé Nuzzaci, Christopher A. Smith, Alice E. Adriaenssens, Lawrence Billing, Cheryl Brighton, Benjamin U. Phillips, John A. Tadross, Sarah J. Kinston, Ernesto Ciabatti, Berthold Göttgens, Marco Tripodi, David Hornigold, David Baker, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101604- (2022)
Objective: Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be orexigenic, and the high fat diet (HFD) preference observed in wildtype mice is altered
Externí odkaz:
https://doaj.org/article/6a6921f8d6fa48b28215077b1699f22b
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate
Externí odkaz:
https://doaj.org/article/ff2b898ea1e54b2b8684c6ba582ddc31