Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Frank, Otto"'
Autor:
Thiago A Patente, Thomas A Gasan, Maaike Scheenstra, Arifa Ozir-Fazalalikhan, Katja Obieglo, Sjoerd Schetters, Stijn Verwaerde, Karl Vergote, Frank Otto, Ruud H P Wilbers, Eline van Bloois, Yolanda van Wijck, Christian Taube, Hamida Hammad, Arjen Schots, Bart Everts, Maria Yazdanbakhsh, Bruno Guigas, Cornelis H Hokke, Hermelijn H Smits
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012457 (2024)
Chronic infection with Schistosoma mansoni parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against allergic airway inflammation (AAI) in mice. One of the main secretory/excretory molecules from s
Externí odkaz:
https://doaj.org/article/8e9219acf37049d6b38930cd17cd8862
Autor:
Luís Almeida, Ruthger van Roey, Thiago Andrade Patente, Frank Otto, Tom Veldhuizen, Mohan Ghorasaini, Angela van Diepen, Gabriele Schramm, Jianyang Liu, Helena Idborg, Marina Korotkova, Per-Johan Jakobsson, Martin Giera, Cornelis Hendrik Hokke, Bart Everts
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The parasitic helminth Schistosoma mansoni is a potent inducer of type 2 immune responses by stimulating dendritic cells (DCs) to prime T helper 2 (Th2) responses. We previously found that S. mansoni soluble egg antigens (SEA) promote the synthesis o
Externí odkaz:
https://doaj.org/article/81da8022d2aa40008df4aeac71952bd4
Autor:
Hendrik J.P. vanderZande, Eline C. Brombacher, Joost M. Lambooij, Leonard R. Pelgrom, Anna Zawistowska-Deniziak, Thiago A. Patente, Graham A. Heieis, Frank Otto, Arifa Ozir-Fazalalikhan, Maria Yazdanbakhsh, Bart Everts, Bruno Guigas
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Obesity-associated metabolic inflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1 (LKB1) has recently been
Externí odkaz:
https://doaj.org/article/a2a53ade54994d4e8b65b8433ec93d8d
Autor:
Saurabh Vig, Joost M. Lambooij, Mette C. Dekkers, Frank Otto, Françoise Carlotti, Bruno Guigas, Arnaud Zaldumbide
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. Accumulating evidence suggests the engagement of cellular stress during the initial stage of the disease, preceding destructio
Externí odkaz:
https://doaj.org/article/61cf86ab88874b8c93ca856edcc182d2
Autor:
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir-Fazalalikhan, Alwin J. van der Ham, Hendrik J.P. van der Zande, Graham A. Heieis, Ramon Arens, Bart Everts
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111032- (2022)
Summary: How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming capacity has primarily been investigated in vitro, but how mTORC1 regulates this in viv
Externí odkaz:
https://doaj.org/article/af5a88d5847d42b5978559763a00c5ea