Výsledky vyhledávání - "Frank, Mendrzyk"

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci

Autor: Bernhard Radlwimmer, Otmar D. Wiestler, Andrey Korshunov, Guido Reifenberger, Andreas E. Kulozik, Stefan Joos, Stefan Rutkowski, Marc Remke, Nicolas U. Gerber, Frank Mendrzyk, Frauke Devens, Peter Lichter, Jörg Felsberg, Andrea Wittmann, Stefan M. Pfister, Axel Benner, Wolfram Scheurlen, Grischa Toedt

Publikováno v: Journal of Clinical Oncology. 27:1627-1636

Purpose Medulloblastoma is the most common malignant brain tumor in children. Current treatment decisions are based on clinical variables. Novel tumor-derived biomarkers may improve the risk stratification of medulloblastoma patients. Patients and Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6cf9453c4fe73238ab1889152dddef
https://doi.org/10.1200/jco.2008.17.9432

Zobrazit plný text záznamu

Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats

Autor: Frank Schwarz, Bernhard Radlwimmer, Frank Mendrzyk, Stefan Joos, Bernhard Korn, Andreas Hochhaus, Andrey Korshunov, Grischa Toedt, Peter Lichter, Claudia Schoch

Publikováno v: Genes, Chromosomes and Cancer. 45:401-410

Medulloblastoma is a highly malignant embryonal tumor of the cerebellum that accounts for 20%-25% of all intracranial pediatric tumors. The most frequent chromosomal rearrangement in medulloblastoma is isochromosome 17, or i(17q). Its frequency sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c4ae7ac35424e14737a701dbbeeb656
https://doi.org/10.1002/gcc.20304

Zobrazit plný text záznamu

High-Resolution Genomic Profiling Reveals Association of Chromosomal Aberrations on 1q and 16p with Histologic and Genetic Subgroups of Invasive Breast Cancer

Autor: Frank Mendrzyk, Bernhard Radlwimmer, Daniel E. Stange, Falk Schubert, Hans Kreipe, Grischa Toedt, Andreas Pich, Peter Lichter, Ulrich Lehmann, Frank Traub, Roland Eils

Publikováno v: Clinical Cancer Research. 12:345-352

Purpose: Invasive ductal carcinoma and invasive lobular carcinoma (ILC) represent the major histologic subtypes of invasive breast cancer. They differ with regard to presentation, metastatic spread, and epidemiologic features. To elucidate the geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125dad0bd072b38df07235e04d387e4a
https://doi.org/10.1158/1078-0432.ccr-05-1633

Zobrazit plný text záznamu

Genomic and Protein Expression Profiling Identifies CDK6 As Novel Independent Prognostic Marker in Medulloblastoma

Autor: Nigel P. Carter, Kai Neben, Andrey Korshunov, Bernhard Radlwimmer, Peter Lichter, Axel Benner, Heike Fiegler, Daniel E. Stange, Frank Mendrzyk, Stefan Joos, Guido Reifenberger, Felix Kokocinski

Publikováno v: Journal of Clinical Oncology. 23:8853-8862

PurposeMedulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly half of the patients die as a result of this tumor. Identification of molecular markers for prognosis and development of nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b46557b18fa07012ef40b8991f5fe4b
https://doi.org/10.1200/jco.2005.02.8589

Zobrazit plný text záznamu

The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma

Autor: Stefan, Pfister, Stephen, Rea, Mikko, Taipale, Frank, Mendrzyk, Beate, Straub, Carina, Ittrich, Olaf, Thuerigen, Hans Peter, Sinn, Asifa, Akhtar, Peter, Lichter

Publikováno v: International journal of cancer. 122(6)

Loss of H4 lysine 16 (H4K16) acetylation was shown to be a common feature in human cancer. However, it remained unclear which enzyme is responsible for the loss of this modification. Having recently identified the histone acetyltransferase human MOF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1be8e2351251d2bb556aded81e7b4ca3
https://pubmed.ncbi.nlm.nih.gov/18058815

Zobrazit plný text záznamu

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas

Autor: Peter Lichter, Wiebke Werft, Wolfram Scheurlen, Grischa Toedt, Stefan M. Pfister, Andrey Korshunov, Andrea Wittmann, Axel Benner, Andreas E. Kulozik, Stefan Rutkowski, Frank Mendrzyk, Bernhard Radlwimmer, Katja von Hoff, Frauke Devens, Marc Remke

Publikováno v: Genes, chromosomescancer. 46(9)

Supratentorial primitive neuroectodermal tumors (stPNETs) and medulloblastomas have long been thought to arise from a common cell type in the subventricular germinal matrix. Because of the infrequent occurrence of stPNETs, little is known about their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a700fe6c60f09e62e85b084071f2bab
https://pubmed.ncbi.nlm.nih.gov/17592618

Zobrazit plný text záznamu

Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma

Autor: Andrea Wittmann, Peter Lichter, Bernhard Radlwimmer, Wolfram Scheurlen, Axel Benner, Andreas E. Kulozik, Stefan M. Pfister, Christof Schlaeger, Frank Mendrzyk

Publikováno v: Nucleic Acids Research

Existing microarray-based approaches for screening of DNA methylation are hampered by a number of shortcomings, such as the introduction of bias by DNA copy-number imbalances in the test genome and negligence of tissue-specific methylation patterns.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64e8383c7b921ac1e9618d704b2d346
https://pubmed.ncbi.nlm.nih.gov/17344319

Zobrazit plný text záznamu

Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma

Autor: Bernhard Radlwimmer, Stefan M. Pfister, Peter Lichter, Axel Benner, Grischa Toedt, Andrey Korshunov, Frank Mendrzyk

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 12(7 Pt 1)

Purpose: Pathogenesis of ependymomas is still poorly understood and molecular markers for risk-adapted patient stratification are not available. Our aim was to screen for novel genomic imbalances and prognostic markers in ependymal tumors. Experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c27333799a66f1effa728ae0e3a605
https://pubmed.ncbi.nlm.nih.gov/16609018

Zobrazit plný text záznamu

Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization

Autor: Daniel E. Stange, Bernhard Radlwimmer, Peter Lichter, Dietmar R. Lohmann, Grischa Toedt, Frank Mendrzyk, Boris Zielinski, Sandrine Gratias

Publikováno v: Genes, chromosomescancer. 43(3)

The genetic hallmark of retinoblastoma is mutation or deletion of the RB1 gene, whereas other genetic alterations that are also required are largely unknown. To screen for genomic imbalances on a genomewide level, we studied a series of 17 primary re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec39c8b0e276cf6bc80ac6640be4f008
https://pubmed.ncbi.nlm.nih.gov/15834944

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání