Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Frank, Hannemann"'
Publikováno v:
Journal of Biotechnology. 325:355-359
Calcifediol (25(OH)VD3) is a physiologically very important vitamin D3 metabolite and of high pharmaceutical importance, due to its potential for treating not only vitamin D3 deficiencies but also coronary diseases and cancer. Previously, we establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b07eb76921a07a334452d15a5942f2
https://doi.org/10.1016/j.jbiotec.2020.09.027
https://doi.org/10.1016/j.jbiotec.2020.09.027
Publikováno v:
Journal of Biotechnology. 294:38-48
Over the past decades, Bacillus megaterium has gained significant interest in the biotechnological industry due to its high capacity for protein production. Although many proteins have been expressed efficiently using the optimized xylose inducible s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c924b6970ea4672939081b75da4b71
https://doi.org/10.1016/j.jbiotec.2019.01.018
https://doi.org/10.1016/j.jbiotec.2019.01.018
Autor:
Frank Hannemann, Rita Bernhardt, Michael C. Hutter, Ammar Abdulmughni, Basma M. EL‐Gayar, Elizabeth M. J. Gillam, Silja J. Strohmaier, Philip Hartz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a1179c712517eb26792ca920aa23df0
https://doi.org/10.1111/febs.16054/v2/response1
https://doi.org/10.1111/febs.16054/v2/response1
Autor:
Philip Hartz, Basma M. EL‐Gayar, Rita Bernhardt, Ammar Abdulmughni, Michael C. Hutter, Silja J. Strohmaier, Elizabeth M. J. Gillam, Frank Hannemann
Publikováno v:
The FEBS journalReferences. 288(22)
Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s were able to retain their oxygenase function following relocation to the mitochondrial matrix an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfbf2fafe1366dfae1b170e0880805c
https://pubmed.ncbi.nlm.nih.gov/34092040
https://pubmed.ncbi.nlm.nih.gov/34092040
Publikováno v:
Journal of biotechnology. 329
Bacillus megaterium has become increasingly important for the biotechnological production of valuable compounds of industrial and pharmaceutical importance. Despite recent advances in rational strain design of B. megaterium, these studies have been l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a237f82429b3c205382e3764294ca2df
https://pubmed.ncbi.nlm.nih.gov/33600891
https://pubmed.ncbi.nlm.nih.gov/33600891
Publikováno v:
Journal of biotechnology. 325
Calcifediol (25(OH)VD3) is a physiologically very important vitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b527978895b6b2c82d26373e40b5a82b
https://pubmed.ncbi.nlm.nih.gov/33268138
https://pubmed.ncbi.nlm.nih.gov/33268138
Publikováno v:
Biotechnology and Applied Biochemistry. 64:315-326
Escherichia coli has developed into an attractive organism for heterologous cytochrome P450 production, but, in some cases, was restricted as a host in view of a screening of orphan cytochromes P450 or mutant libraries in the context of molecular evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8302bed7ddf9fc0c76558f168a2c5343
https://doi.org/10.1002/bab.1488
https://doi.org/10.1002/bab.1488
Autor:
Josef Zapp, Elisa Brill, Andy-Mark W. H. Thunnissen, Rita Bernhardt, Ilona K. Jóźwik, Frank Hannemann, Natalia Putkaradze, Ammar Abdulmughni
Publikováno v:
Journal of Biotechnology, 243, 38-47. Elsevier
In this study the ability of CYP109E1 from Bacillus megaterium to metabolize vitamin D3 (VD3) was investigated. In an in vitro system using bovine adrenodoxin reductase (AdR) and adrenodoxin (Adx4-108), VD3 was converted by CYP109E1 into several prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9691216556031f30481716923f0b7f
https://research.rug.nl/en/publications/7f9e6bc4-febf-4036-b74f-6b0b95a60c24
https://research.rug.nl/en/publications/7f9e6bc4-febf-4036-b74f-6b0b95a60c24
Autor:
Lisa König, Frank Hannemann, Rita Bernhardt, Daniela Tavouli‐Abbas, Mohammed Milhim, Simone Brixius-Anderko, Michael C. Hutter
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(4)
Synthetic glucocorticoids such as methylprednisolone are compounds of fundamental interest to the pharmaceutical industry as their modifications within the sterane scaffold lead to higher inflammatory potency and reduced side effects compared with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb66e66085a7ef5ab7bc69c1564dee03
https://pubmed.ncbi.nlm.nih.gov/31814109
https://pubmed.ncbi.nlm.nih.gov/31814109
Autor:
Martin Litzenburger, Natalia Putkaradze, Rita Bernhardt, Elisa Brill, Frank Hannemann, Mohammed Milhim, Ammar Abdulmughni
CYP109E1 is a cytochrome P450 monooxygenase from Bacillus megaterium with a hydroxylation activity for testosterone and vitamin D3. This study reports the screening of a focused library of statins, terpene-derived and steroidal compounds to explore t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dd3ba13b132217426e18c77c8ffb0a