Zobrazeno 1 - 10
of 443
pro vyhledávání: '"Frank, Grosveld"'
Autor:
Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J. M. van Kuppeveld, Frank Grosveld, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown. The virus relies on its spike (S) protein for cell e
Externí odkaz:
https://doaj.org/article/9dcf63e5b3054d1fac1699924a218ec5
Autor:
Lucas Kuijpers, Bastian Hornung, Mirjam C. G. N. van den Hout - van Vroonhoven, Wilfred F. J. van IJcken, Frank Grosveld, Eskeatnaf Mulugeta
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Single-cell sequencing techniques are revolutionizing every field of biology by providing the ability to measure the abundance of biological molecules at a single-cell resolution. Although single-cell sequencing approaches have be
Externí odkaz:
https://doaj.org/article/2529024ff6db4061927e54fffe6e9d30
Autor:
Franziska K. Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z. Mykytyn, Mathijs P. Raadsen, Mart M. Lamers, Francine Rodrigues Ianiski, Tatiana M. Shamorkina, Joost Snijder, Federico Armando, Georg Beythien, Malgorzata Ciurkiewicz, Tom Schreiner, Eva Gruber-Dujardin, Martina Bleyer, Olga Batura, Lena Erffmeier, Rabea Hinkel, Cheila Rocha, Monica Mirolo, Dubravka Drabek, Berend-Jan Bosch, Mark Emalfarb, Noelia Valbuena, Ronen Tchelet, Wolfgang Baumgärtner, Markku Saloheimo, Stefan Pöhlmann, Frank Grosveld, Bart L. Haagmans, Albert D.M.E. Osterhaus
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Monoclonal antibodies are an increasingly important tool for prophylaxis and treatment of acute virus infections like SARS-CoV-2 infection. However, their use is often restricted due to the time required for development, variable yields and
Externí odkaz:
https://doaj.org/article/98f6041d164849c48be914ce65c5b198
Autor:
Rick Janssens, Rien van Haperen, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Dubravka Drabek
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane-a
Externí odkaz:
https://doaj.org/article/3c74ea07b1e04f779a3a5ebe46da50e4
Autor:
Julien Slagboom, Abigail H. Lewis, Wietse M. Schouten, Rien van Haperen, Mieke Veltman, Mátyás A. Bittenbinder, Freek J. Vonk, Nicholas R. Casewell, Frank Grosveld, Dubravka Drabek, Jeroen Kool
Publikováno v:
Toxicon: X, Vol 21, Iss , Pp 100185- (2024)
Snakebite envenoming is a priority Neglected Tropical Disease that causes an estimated 81,000–135,000 fatalities each year. The development of a new generation of safer, affordable, and accessible antivenom therapies is urgently needed. With this g
Externí odkaz:
https://doaj.org/article/aa72a3429ba844ee87def2003bd12c3d
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-11 (2023)
Abstract Our understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last few years. High-resolution techniques based on next-generation sequencing as well as optical imaging that can investigat
Externí odkaz:
https://doaj.org/article/719bedbff6f34092a88999c249134d05
Autor:
Karol Nowosad, Rutger W. W. Brouwer, Adrian Odrzywolski, Anne L. Korporaal, Bartłomiej Gielniewski, Bartosz Wojtaś, Wilfred F. J. van IJcken, Frank Grosveld, Danny Huylebroeck, Przemko Tylzanowski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The formation of the synovial joint begins with the visible emergence of a stripe of densely packed mesenchymal cells located between distal ends of the developing skeletal anlagen called the interzone. Recently the transcriptome of the earl
Externí odkaz:
https://doaj.org/article/1d1993d01b414e72859fe01102787e3e
Autor:
Chunyan Wang, Emma L. Hesketh, Tatiana M. Shamorkina, Wentao Li, Peter J. Franken, Dubravka Drabek, Rien van Haperen, Sarah Townend, Frank J. M. van Kuppeveld, Frank Grosveld, Neil A. Ranson, Joost Snijder, Raoul J. de Groot, Daniel L. Hurdiss, Berend-Jan Bosch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodi
Externí odkaz:
https://doaj.org/article/a254f75862064c1d9048eaf549552960
Autor:
Wenjuan Du, Rick Janssens, Anna Z. Mykytyn, Wentao Li, Dubravka Drabek, Rien van Haperen, Marianthi Chatziandreou, Melanie Rissmann, Joline van der Lee, Melissa van Dortmondt, Itziar Serna Martin, Frank J. M. van Kuppeveld, Daniel L. Hurdiss, Bart L. Haagmans, Frank Grosveld, Berend-Jan Bosch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Emerging SARS-CoV-2 variants have accrued mutations within the spike protein rendering most therapeutic monoclonal antibodies against COVID-19 ineffective. Hence there is an unmet need for broad-spectrum mAb treatments for COVID-19 that are more resi
Externí odkaz:
https://doaj.org/article/a2e974cb90cd4149a3c38cfea0d08f4d
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Modern-day hematopoietic stem cell (HSC) therapies, such as gene therapy, modify autologous HSCs prior to re-infusion into myelo-conditioned patients and hold great promise for treatment of hematological disorders. While this approach has been succes
Externí odkaz:
https://doaj.org/article/dd8b9d0eff7a42b39bd9a3f5eb845088