Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Frank, Eisenhaber"'
Autor:
Nithin R. Iyer, Siew-Pang Chan, Oi Wah Liew, Jenny P.C. Chong, Jennifer A. Bryant, Thu-Thao Le, Chanchal Chandramouli, Patrick J. Cozzone, Frank Eisenhaber, Roger Foo, A. Mark Richards, Carolyn S.P. Lam, Martin Ugander, Calvin W-L. Chin, on behalf of the ATTRaCT investigators
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Heart failure (HF) and diabetes are associated with increased incidence and worse prognosis of each other. The prognostic value of global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been e
Externí odkaz:
https://doaj.org/article/50c9a119501141aaba899532f7f7c77d
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chronological lifespan in human cell
Externí odkaz:
https://doaj.org/article/e6061c31863549b8ad5d29645c27f527
Autor:
Mohammad Alfatah, Jolyn Jia Jia Lim, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng, Sonia Yogasundaram, Nashrul Afiq Faidzinn, Jovian Jing Lin, Birgit Eisenhaber, Frank Eisenhaber
Publikováno v:
eLife, Vol 12 (2024)
Uncovering the regulators of cellular aging will unravel the complexity of aging biology and identify potential therapeutic interventions to delay the onset and progress of chronic, aging-related diseases. In this work, we systematically compared gen
Externí odkaz:
https://doaj.org/article/6d69ed0e4b1c4eccb799998c85be894a
Autor:
Alok K. Mishra, Tianyi Ye, Shahid Banday, Ritesh P. Thakare, Chinh Tran-To Su, Ngoc N.H. Pham, Amjad Ali, Ankur Kulshreshtha, Shreya Roy Chowdhury, Tessa M. Simone, Kai Hu, Lihua Julie Zhu, Birgit Eisenhaber, Sara K. Deibler, Karl Simin, Paul R. Thompson, Michelle A. Kelliher, Frank Eisenhaber, Sunil K. Malonia, Michael R. Green
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114041- (2024)
Summary: CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a “don’t eat me” signal that prevents targeting and phagocytos
Externí odkaz:
https://doaj.org/article/51c10ad4e53242b1b570a3e817e3e103
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Background Although the genome of Saccharomyces cerevisiae (S. cerevisiae) was the first one of a eukaryote organism that was fully sequenced (in 1996), a complete understanding of the potential of encoded biomolecular mechanisms has not yet
Externí odkaz:
https://doaj.org/article/d2ad1d9ec5894b0c9629b84943f3455a
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background Although Escherichia coli (E. coli) is the most studied prokaryote organism in the history of life sciences, many molecular mechanisms and gene functions encoded in its genome remain to be discovered. This work aims at quantifying
Externí odkaz:
https://doaj.org/article/6d444852c2c447d88ec83f2ff13fe8d7
Autor:
Erwin Tantoso, Birgit Eisenhaber, Miles Kirsch, Vladimir Shitov, Zhiya Zhao, Frank Eisenhaber
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-26 (2022)
Abstract Background Escherichia coli (E. coli) has been one of the most studied model organisms in the history of life sciences. Initially thought just to be commensal bacteria, E. coli has shown wide phenotypic diversity including pathogenic isolate
Externí odkaz:
https://doaj.org/article/d0485d63426d40958e0a0bf703f0273d
Autor:
Birgit Eisenhaber, Swati Sinha, Chaitanya K. Jadalanki, Vladimir A. Shitov, Qiao Wen Tan, Fernanda L. Sirota, Frank Eisenhaber
Publikováno v:
Biology Direct, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background The human proteins TMTC1, TMTC2, TMTC3 and TMTC4 have been experimentally shown to be components of a new O-mannosylation pathway. Their own mannosyl-transferase activity has been suspected but their actual enzymatic potential has
Externí odkaz:
https://doaj.org/article/fed922648154468882676b99654838c7
Publikováno v:
Biology Direct, Vol 15, Iss 1, Pp 1-17 (2020)
Abstract Background The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal propeptide with a defined
Externí odkaz:
https://doaj.org/article/19ee47b62dc748eb826c98a0437435ce
Autor:
Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-13 (2020)
Abstract Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal screening campaign, we identifie
Externí odkaz:
https://doaj.org/article/ec0148909bdf449eae2f3e74c507b601