Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Frank, Dieterle"'
Autor:
Carolin A. Imbery, Frank Dieterle, Claudia Ottka, Corinna Weber, Götz Schlotterbeck, Elisabeth Müller, Hannes Lohi, Urs Giger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS,
Externí odkaz:
https://doaj.org/article/f1e934d555284afb995964a5ca58674e
Autor:
Carolin Anna Imbery, Frank Dieterle, Claudia Ottka, Corinna Weber, Götz Schlotterbeck, Elisabeth Müller, Hannes Lohi, Urs Giger
Publikováno v:
Metabolites, Vol 12, Iss 4, p 339 (2022)
The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic and therapeutic challenge. S
Externí odkaz:
https://doaj.org/article/ad6a793a323d406c9dbda3f000b22feb
Autor:
Frank Dieterle
While multiple publications have described the use of biomarkers for personalized medicine in early stages, only limited numbers of biomarkers have progressed to use in patient care, owing to limitations in the scientific evidence, the development re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdec044b3fc427fa6bf8c59fb011a5c1
https://doi.org/10.1016/b978-0-12-820493-1.00011-8
https://doi.org/10.1016/b978-0-12-820493-1.00011-8
Publikováno v:
CHIMIA, Vol 61, Iss 10 (2007)
Externí odkaz:
https://doaj.org/article/9020971bf4084d13887c34c1c1690ea7
Autor:
Alexander, Amberg, Björn, Riefke, Götz, Schlotterbeck, Alfred, Ross, Hans, Senn, Frank, Dieterle, Matthias, Keck
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1641
Metabolomics, also often referred as "metabolic profiling," is the systematic profiling of metabolites in biofluids or tissues of organisms and their temporal changes. In the last decade, metabolomics has become more and more popular in drug developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aa5c79e9e101698df3f19f20611021b
https://pubmed.ncbi.nlm.nih.gov/28748468
https://pubmed.ncbi.nlm.nih.gov/28748468
Autor:
Alexander Amberg, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Frank Dieterle, Matthias Keck
Publikováno v:
Methods in Molecular Biology ISBN: 9781493971701
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41c0c89001c8eb0bf9e8c80d21f9164
https://doi.org/10.1007/978-1-4939-7172-5_13
https://doi.org/10.1007/978-1-4939-7172-5_13
Autor:
Laura Suter, Aliza Thompson, Ernie Harpur, Gerard Maurer, Bruno Flamion, Douglas C. Throckmorton, Phil Rossi, Jackie Akunda, Nancy Xu, Stefan Sultana, Federico Goodsaid, Jonathan A. Phillips, Sven A. Beushausen, Valérie G. Barlow, Denise Bounous, Jacky Vonderscher, David Gerhold, Sean P. Troth, Elizabeth Hausner, Karol L. Thompson, Matthew J. Schipper, Spiros Vamvakas, David Jacobson-Kram, William Taylor, Jean Marc Vidal, Beatriz Silva Lima, Albert F. Defelice, Supriya Jayadev, Magalie Guffroy, Yi Zhong Gu, James Eric McDuffie, Daniela Ennulat, Jeff Waring, Patricia Harlow, Leslie A. Obert, Sandra Snook, Frank D. Sistare, Eric A.G. Blomme, William B. Mattes, Craig P. Webb, Mark Pinches, David Honor, Romaldas Mačiulaitis, Myrtle Davis, Jinhe Lee, Frank Dieterle, Marisa Papaluca, Melanie Blank, Nathaniel Collins, William Baer, Peter L. Goering, Shen Xiao, Anthony J. Senagore, Krishna Prasad, Denise Robinson-Gravatt, Josef S Ozer, Eric Abadie, Graham Betton, Kevin Carl, Peter Kasper, David Laurie, Manisha Sonee, Dina Andrews-Cleavenger, Elizabeth G. Walker, Dan Holder, Markku Pasanen
Publikováno v:
Nature Biotechnology. 28:455-462
The first formal qualification of safety biomarkers for regulatory decision making marks a milestone in the application of biomarkers to drug development. Following submission of drug toxicity studies and analyses of biomarker performance to the Food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153a6b13ac5e7fb2e36ce91685f63c53
https://doi.org/10.1038/nbt.1625
https://doi.org/10.1038/nbt.1625
Autor:
Daniel J. Holder, Douglas Thudium, Francois Legay, P. F. Verdes, Salah-Dine Chibout, Warren E. Glaab, Sean P. Troth, Frank D. Sistare, Wendy J. Bailey, Andreas Mahl, Frank Staedtler, David Gerhold, Katerina Vlasakova, Michael J Topper, Hong Jin, Frank Dieterle, Daniel Robert Roth, Gerard Maurer, Zoltan Erdos, Spencer Reynolds, Daniel Wahl, Yan Yu, Joseph F. Sina, André Cordier, Tom Forest, Elias Perentes, Holly K Clouse, Thomas R. Skopek, Olivier Grenet, Jacky Vonderscher, Nagaraja Muniappa, Josef S Ozer
Publikováno v:
Nature Biotechnology. 28:486-494
The Predictive Safety Testing Consortium's first regulatory submission to qualify kidney safety biomarkers revealed two deficiencies. To address the need for biomarkers that monitor recovery from agent-induced renal damage, we scored changes in the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be18e7daf842766d51dfd09786e797eb
https://doi.org/10.1038/nbt.1627
https://doi.org/10.1038/nbt.1627
Publikováno v:
Nature Biotechnology. 28:436-440
There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e12613efdbcbacc959696537d9a905
https://doi.org/10.1038/nbt0510-436
https://doi.org/10.1038/nbt0510-436