Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Frank, Costantini"'
Autor:
Pamela I. Good, Ling Li, Holly A. Hurst, Ileana Serrano Herrera, Katherine Xu, Meenakshi Rao, David A. Bateman, Qais Al-Awqati, Vivette D. D’Agati, Frank Costantini, Fangming Lin
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%
Externí odkaz:
https://doaj.org/article/c77b63374e4a4df497ef65ec62d8c85d
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 127-137 (2014)
Nephrons, the functional units of the kidney, develop from progenitor cells (cap mesenchyme [CM]) surrounding the epithelial ureteric bud (UB) tips. Reciprocal signaling between UB and CM induces nephrogenesis and UB branching. Although low nephron n
Externí odkaz:
https://doaj.org/article/9dcf189a4bbc4c0691847062a9e5f85e
Publikováno v:
PLoS Biology, Vol 14, Iss 2, p e1002382 (2016)
Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephron number, while low nephron number is implicated in hypertension and renal disease. Ureteric bud growth and branching requi
Externí odkaz:
https://doaj.org/article/024466790d2540c6ad1f61144b9ad22f
Autor:
Anneliis Ihermann-Hella, Maria Lume, Ilkka J Miinalainen, Anniina Pirttiniemi, Yujuan Gui, Johan Peränen, Jean Charron, Mart Saarma, Frank Costantini, Satu Kuure
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004193 (2014)
Although the growth factor (GF) signaling guiding renal branching is well characterized, the intracellular cascades mediating GF functions are poorly understood. We studied mitogen-activated protein kinase (MAPK) pathway specifically in the branching
Externí odkaz:
https://doaj.org/article/eb8667839a81469e916e3de3647bc746
Publikováno v:
Development
Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret-expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips to generate
Autor:
Satu Kuure, Cristina Cebrian, Quentin Machingo, Benson C Lu, Xuan Chi, Deborah Hyink, Vivette D'Agati, Christine Gurniak, Walter Witke, Frank Costantini
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001176 (2010)
The actin depolymerizing factors (ADFs) play important roles in several cellular processes that require cytoskeletal rearrangements, such as cell migration, but little is known about the in vivo functions of ADFs in developmental events like branchin
Externí odkaz:
https://doaj.org/article/86dee68d369d49f882836a7dbd9dd8e6
Autor:
Odyssé Michos, Cristina Cebrian, Deborah Hyink, Uta Grieshammer, Linda Williams, Vivette D'Agati, Jonathan D Licht, Gail R Martin, Frank Costantini
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000809 (2010)
GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans. Furthermore, many other mutant genes that cause renal agenesis exert their effects v
Externí odkaz:
https://doaj.org/article/0570a987a25d461193ef088a4b034c59
Publikováno v:
PLoS Biology, Vol 6, Iss 12, p e310 (2008)
SUMO-specific protease 2 (SENP2) modifies proteins by removing SUMO from its substrates. Although SUMO-specific proteases are known to reverse sumoylation in many defined systems, their importance in mammalian development and pathogenesis remains lar
Externí odkaz:
https://doaj.org/article/36f7e505978d49c1acfaa282e85fd0b3
Autor:
David Grote, Sami Kamel Boualia, Abdallah Souabni, Calli Merkel, Xuan Chi, Frank Costantini, Thomas Carroll, Maxime Bouchard
Publikováno v:
PLoS Genetics, Vol 4, Iss 12, p e1000316 (2008)
Metanephric kidney induction critically depends on mesenchymal-epithelial interactions in the caudal region of the nephric (or Wolffian) duct. Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating
Externí odkaz:
https://doaj.org/article/59356595d08c45f79fa39d9fc71d9fb9
Autor:
Frank, Costantini
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1926
For studies of gene function during development, it can be very useful to generate mosaic embryos in which a small subset of cells in a given cell lineage lacks a gene of interest and carries a marker that allows the mutant cells to be specifically v