Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Frank, Begrow"'
Publikováno v:
Molecules, Vol 27, Iss 19, p 6622 (2022)
Extracts from Drosera rotundifolia are traditionally used to treat cough symptoms during a common cold. The present study aimed to investigate the impact of extracts from D. rotundifolia and active compounds on the respiratory tract. Tracheal slices
Externí odkaz:
https://doaj.org/article/e5345eeb58d444cfad8749919f1ea391
Autor:
Frank Begrow, Eugen J. Verspohl
Publikováno v:
Pharmacology & Pharmacy. :176-181
Cystic fibrosis is a life-threatening, wide spread genetic disease diagnosed in 1 to 3000 livebirths of the Caucasian population. Here a mouse model for this disease is described and optimized using the CFTR-channel selective inhibitor CFTR(inh 172).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33df58d0f228e6fb7b9d1b5c02e12b5c
https://doi.org/10.4236/pp.2013.42025
https://doi.org/10.4236/pp.2013.42025
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:123-132
Objectives Adenosine is known to induce a bronchospasm in asthma- and COPD patients. The role of A2B receptors was investigated with respect to several parameters of the respiratory tract: tonus of smooth muscle, ciliary beat frequency as measured by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05045106729b2547ab8d3480888f2f3
https://doi.org/10.1111/j.2042-7158.2012.01580.x
https://doi.org/10.1111/j.2042-7158.2012.01580.x
Publikováno v:
Planta Medica. 73:629-635
UNLABELLED Thyme is a broncholytic und secretomotoric agent. Thus, our aim was to investigate the influence of a thyme extract on beta (2)-receptors in competition binding experiments and relaxation experiments on rat uteri and trachea. Furthermore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76bbc5d85e037ffc7f8d5d83e546124
https://doi.org/10.1055/s-2007-981535
https://doi.org/10.1055/s-2007-981535
Autor:
Gabriela Hanske, Uta Reinke, Marek Matus, Joachim Neumann, Peter Boknik, Frank Begrow, Wilhelm Schmitz, G. Paul Matherne, Isabel Justus
Publikováno v:
Cardiovascular Research. 60:529-537
Objective: The aim of the present study was to assess the effects of A1-adenosine receptor (A1-AR) stimulation in ventricle of A1-adenosine receptor overexpressing mice (transgenic mice, TG). Methods: Effects of the A1-adenosine receptor agonist R-PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fdf41b49d9372af5c37b5ed386661f
https://doi.org/10.1016/j.cardiores.2003.09.012
https://doi.org/10.1016/j.cardiores.2003.09.012
Autor:
Kai C. Wollert, Suzanne M. Lohmann, Frank Begrow, Ulrich Walter, Sevdalina Yurukova, Stepan Gambaryan, Ana Kilic, Michaela Kuhn, Beate Fiedler
Publikováno v:
British Journal of Pharmacology. 140:1227-1236
C-type natriuretic peptide (CNP) and its receptor guanylyl cyclase (GC-B) are expressed in the heart and modulate cardiac contractility in a cGMP-dependent manner. Since the distal cellular signalling pathways remain unclear, we evaluated the peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f9c0a5a89ca30351275e84ebe469f80
https://doi.org/10.1038/sj.bjp.0705567
https://doi.org/10.1038/sj.bjp.0705567
Autor:
Rita Holtwick, Boris V. Skryabin, Frank Begrow, Alexander Bubikat, Hideo A. Baba, Martin van Eickels, Michael D. Schneider, David L. Garbers, Michaela Kuhn
Publikováno v:
Journal of Clinical Investigation. 111:1399-1407
Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Atrial natriuretic peptide (ANP) has been postulated to exert local antihypertrophic effects in the heart. Thus, a loss of function of the ANP receptor guanylyl c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3712ba3124f3322a7d587da5f4ac2f
https://doi.org/10.1172/jci17061
https://doi.org/10.1172/jci17061
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 94
Structural modification of the GluN2B selective NMDA receptor antagonist ifenprodil led to the 3-benzazepine WMS-1410 with similar GluN2B affinity but higher receptor selectivity. Herein the in vitro and in vivo biotransformation of WMS-1410 is repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfb9be041a0c4aaef6476874e3526fd
https://pubmed.ncbi.nlm.nih.gov/24534302
https://pubmed.ncbi.nlm.nih.gov/24534302
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 88
The NMDA receptor antagonist ifenprodil is an important lead structure for developing new GluN2B selective NMDA receptor antagonists. Ifenprodil itself has a high affinity to the GluN2B subunit but a poor selectivity for the NMDA receptor. This aspec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee33bd606df3c4a79d1f8ab65512fce
https://pubmed.ncbi.nlm.nih.gov/24042122
https://pubmed.ncbi.nlm.nih.gov/24042122
Publikováno v:
Planta medica. 78(8)
Silymarin and harpagoside are derived from drugs which are used for their protective effects against hepatotoxicity and inflammatory processes. Both are now investigated with respect to the respiratory tract. They were able to reduce the release of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5618bdceb710be7caea2955d09527af
https://pubmed.ncbi.nlm.nih.gov/22411727
https://pubmed.ncbi.nlm.nih.gov/22411727