Výsledky vyhledávání - "Frank, Balis"

Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment

Autor: Catherine Lai, Diane E. Cole, Seth M. Steinberg, Nicole Lucas, Eva Dombi, Christopher Melani, Mark Roschewski, Frank Balis, Brigitte C. Widemann, Wyndham H. Wilson

Publikováno v: Blood Advances. 7:529-532

Aggressive lymphomas are curable with doxorubicin-based chemotherapy. In patients presenting with elevated serum bilirubin, doxorubicin is commonly dose reduced or delayed based on limited pharmacokinetic data. We evaluated plasma pharmacokinetics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef3df87608aed09ba3c21a05f44f620
https://doi.org/10.1182/bloodadvances.2022007431

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Data from A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

Autor: Tito Fojo, Susan E. Bates, Olaf Van Tellingen, Frank Balis, Barry Goldspiel, Andrew Dwyer, Rob Robey, Susan Bakke, Ann Rutt, Clara Chen, Richard Wilson, Maureen Edgerly, Jame Abraham

Purpose: P-glycoprotein (Pgp) antagonists have had unpredictable pharmacokinetic interactions requiring reductions of chemotherapy. We report a phase I study using tariquidar (XR9576), a potent Pgp antagonist, in combination with vinorelbine.Experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d530611d13c96f5fb5d2ab30697e39e
https://doi.org/10.1158/1078-0432.c.6517044

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A phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer

Autor: Lebowitz, P. F., Eng-Wong, J., Widemann, B. C., Frank Balis, Jayaprakash, N., Chow, C., Clark, G., Gantz, S. B., Venzon, D., Zujewski, J.

Publikováno v: Scopus-Elsevier

Purpose: Farnesyltransferase (FTase) inhibitors, which were designed to inhibit oncogenic Ras, act synergistically with tamoxifen in preclinical breast cancer models. We studied the safety and toxicity of tipifarnib in combination with tamoxifen in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d6755abdfa7d52ccaf2c91f6e7b5df
https://pubmed.ncbi.nlm.nih.gov/15709195

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Mixing during intravertebral arterial infusions in an in vitro model

Autor: Robert J, Lutz, Kathy, Warren, Frank, Balis, Nicholas, Patronas, Robert L, Dedrick

Publikováno v: Journal of neuro-oncology. 58(2)

Regional delivery of drugs can offer a pharmacokinetic advantage in the treatment of localized tumors. One method of regional delivery is by intra-arterial infusion into the basilar/vertebral artery network that provides local access to infratentoria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c0a6140dcecb3a75312d45854d1b2f7
https://pubmed.ncbi.nlm.nih.gov/12164691

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Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates

Autor: Warren, K. E., Patel, M. C., Mccully, C. M., Montuenga, L. M., Frank Balis

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Scopus-Elsevier

PURPOSE: P-glycoprotein (Pgp) is a transmembrane drug efflux pump that is expressed in multidrug-resistant cancer cells and in a variety of normal tissues, including brain capillary endothelial cells which comprise the blood-brain barrier. We studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b840a5731c5be3459ab85a27feead37
https://hdl.handle.net/10171/20174

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Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome

Autor: Carmen J. Allegra, Bruce A. Chabner, Carmelita U. Tuazon, Debra Ogata-Arakaki, Barbara Baird, James C. Drake, J. Thayer Simmons, Ernest E. Lack, James H. Shelhamer, Frank Balis, Robert Walker, Joseph A. Kovacs, H. Clifford Lane, Henry Masur

Publikováno v: The New England journal of medicine. 317(16)

Preclinical studies have demonstrated that trimetrexate is a potent inhibitor of dihydrofolate reductase from Pneumocystis carinii. On the basis of this evidence, this lipid-soluble antifolate was used as an antipneumocystis agent in 49 patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46eedd860d5bfb22feb279b8893c763b
https://pubmed.ncbi.nlm.nih.gov/2958710

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