The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity.

Autor: Guizzo JA; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Chaudhuri S; Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada., Prigol SR; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Yu RH; Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada., Dazzi CC; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Balbinott N; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Frandoloso GP; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Kreutz LC; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil., Frandoloso R; Laboratory of Microbiology and Advanced Immunology, Faculty of Agronomy and Veterinary Medicine, University of Passo Fundo, Passo Fundo, 99052-900, Brazil. rfran@upf.br., Schryvers AB; Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. schryver@ucalgary.ca.

Publikováno v: Scientific reports [Sci Rep] 2018 May 09; Vol. 8 (1), pp. 7372. Date of Electronic Publication: 2018 May 09.