Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Francoise Powell"'
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
Supplementary Materials and Methods: Cell line treatment Gene expression microarray Whole exome DNA sequencing Theranostics health reverse phase protein array Protein array data transformation for executable network model construction PhosphoScan pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9b383b82a5845707a9b2379f3f086d
https://doi.org/10.1158/0008-5472.22416533.v1
https://doi.org/10.1158/0008-5472.22416533.v1
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
The following tables are supplied in the excel file due to their sizes: Table S6. Phosphosite Overlap. PhosphoScan mass-spectrometry in MOLM16 cells after 3 hour treatment with AZD1208 Table S7. Literature Entries. Full literature entries. Table S8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb152958e30799e2310eea005ed16ab
https://doi.org/10.1158/0008-5472.22416530.v1
https://doi.org/10.1158/0008-5472.22416530.v1
Autor:
Jasmin Fisher, Jonathan Dry, Berthold Gottgens, Francoise Powell, Dennis Wang, Shaun Grosskurth, Dana Silverbush
Figure S1. A schematic representation for the method of transforming the log2 linear RPPA values to a 5 point categorical scale suitable for BMA modeling. Figure S2. Differential AML signaling responses to single agent PIM inhibition with AZD1208 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc8a130edd3747af7df20ce96d71686
https://doi.org/10.1158/0008-5472.22416536
https://doi.org/10.1158/0008-5472.22416536
Autor:
Gaurang Patel, Adrian Sheldon, David Plourde, Susan Dearborn, Patty Walton, Allison Lewia, Francoise Powell, Jakal Amin
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S52
Autor:
Jonathan R. Dry, Berthold Göttgens, Francoise Powell, Dennis Wang, Dana Silverbush, Jasmin Fisher, Shaun E. Grosskurth
Publikováno v:
Cancer research. 77(4)
Personalized therapy is a major goal of modern oncology, as patient responses vary greatly even within a histologically defined cancer subtype. This is especially true in acute myeloid leukemia (AML), which exhibits striking heterogeneity in molecula
Autor:
Kate Byth, Jon Read, Rong-Fang Gu, Jamal Carlos Saeh, Jiaquan Wu, Mark Roth, Dorin Toader, Zhongwu Lai, Huawei Chen, Francoise Powell, Nicholas A. Larsen
Publikováno v:
ACS chemical biology. 8(3)
Transforming growth factor-β activated kinase-1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that regulates several signaling pathways including NF-κB signal transduction and p38 activation. TAK1 deregulat
Autor:
Terry MacIntyre, Corinne Reimer, Alwin Schuller, Kate Byth, Francoise Powell, Ammar Adam, Paul Secrist, Deborah Lawson
Publikováno v:
Blood. 124:5304-5304
Over-expression of the antiapoptotic proteins Bcl-2 and Bcl-xL provides a common mechanism through which cancer cells gain a survival advantage and become resistant to conventional standard of care therapies. Because Bcl-2 family members play key, bu
Autor:
Altaf Kassam, Paul L. Gunyuzlu, Kathleen Murphy, John Link, Gregory F Hollis, Bowman Miao, Mark J Rupar, Peter R. Young, Mark R. Cunningham, Timothy C. Burn, Reid M. Huber, Ranjan Mukherjee, Thomas F. Haws, Francoise Powell
Publikováno v:
Gene. 290(1-2)
Bile acid biosynthesis is regulated by both feed-forward and feedback mechanisms involving a cascade of nuclear hormone receptors. Feed-forward regulation of the rate limiting enzyme in bile acid biosynthesis is provided by oxysterols through liver-X
Autor:
Kate Byth, Francoise Powell, Corinne Reimer, Nin Guan, Jamal Carlos Saeh, Dorin Toader, Raymond Chen
Publikováno v:
Cancer Research. 73:2459-2459
Transforming growth factor β-activated kinase 1 (TAK1), a member of the MAPKKK family, is a key mediator of proinflammatory and stress signaling. It was shown previously that inhibition of TAK1 via the use of siRNA or small-molecule kinase inhibitor
Autor:
Kate Byth, Yue Zhang, Zhongwu Lai, Francoise Powell, Julie Parmentier, Melissa Passino, Greg O'Connor, Erik Devereaux
Publikováno v:
Blood. 120:3720-3720
Abstract 3720 Spleen tyrosine kinase (SYK) plays a key role in B cell receptor mediated survival in certain B cell malignancies including Diffuse Large B Cell Lymphoma (DLBCL). Therefore, targeting SYK represents an emerging therapeutic approach for