Výsledky vyhledávání - "Francoise Bouchoux"

Synthesis and binding affinity to human α and β estrogen receptors of various 7-hydroxycoumarins substituted at 4- and 3,4- positions

Autor: Serge Kirkiacharian, Anh Tuan Lormier, Evelyne Cerede, Francoise Bouchoux, Henri Chidiack

Publikováno v: Il Farmaco. 59:981-986

The study of the relative binding affinity (RBA) to the human alpha and beta estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERalpha and ERbeta. The 4-(4-hydroxyphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3259d98cfa6b521e601731dcfa9524
https://doi.org/10.1016/j.farmac.2004.08.004

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Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls

Autor: Bernadette Tric, E. Cerede, Dominique Lesuisse, Georges Teutsch, Sophie Tessier, Jean-Michel Lefrancois, Eva Albert, Francoise Bouchoux, Marc-Olivier Levif

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:1709-1712

In the course of a programme aimed at discovering new ligands of the estrogen receptor, we explored a series of substituted biphenyls. Their synthesis and binding affinity are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4ec805f9959c70ee56ea94d8ce6df3
https://doi.org/10.1016/s0960-894x(01)00267-0

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RU 58 668, a new pure antiestrogen inducing a regression of human mammary carcinoma implanted in nude mice

Autor: Francoise Bouchoux, F. Nique, D. Lucas, S. Viet, J. Bremaud, C. Moratille, M. C. Hameau, Daniel Philibert, P. Van de Velde, G. Teutsch

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 48:187-196

RU 58 668, a new steroidal antiestrogen, has been synthesized. Its in vitro and in vivo pharmacological activities have been compared to those of tamoxifen and ICI 182,780. In vitro, it displayed affinities for human and murine estrogen receptors equ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550448f490453bcd54e482577fd9b97a
https://doi.org/10.1016/0960-0760(94)90144-9

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Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor

Autor: D. Gofflo, Evelyne Cerede, T. Battmann, G. Teutsch, Martine Gaillard-Kelly, A. Bonfils, Daniel Philibert, Francoise Bouchoux, Francois Goubet

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 48:111-119

New N-substituted arylthiohydantoin antiandrogens were synthesized. These compounds presented exceptionally high relative binding affinities (RBAs) for the rat androgen receptor (AR): up to 3 times that of testosterone (T) and 100 times the RBAs of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b010fd3f3b732626498cf6d6f8415a3
https://doi.org/10.1016/0960-0760(94)90257-7

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Synthesis of a fluorescent steroid derivative with high affinities for the glucocorticoid and progesterone receptors

Autor: G. Teutsch, Francoise Bouchoux, Daniel Philibert, Evelyne Cerede, Michel Klich

Publikováno v: Steroids. 59:22-26

The synthesis of RU 45196, an 11β-substituted 19-norsteroid of the estra-4,9-diene series, incorporating the nitrobenzoxadiazole (NBD) fluorophore, is reported. The highly fluorescent target compound displayed remarkable affinity for both the proges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20e1dcdb4a0cb63f58b78ebee816d19
https://doi.org/10.1016/0039-128x(94)90040-x

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ChemInform Abstract: Synthesis and Relative Binding Affinity to Steroid Receptors and Antiproliferative Activity on MCF-7 Cells of 2,3-Disubstituted Indenes

Autor: Francoise Bouchoux, Serge Kirkiacharian, Daniel Philibert, Pantelis G. Koutsourakis, Patrick Van De Velde

Publikováno v: ChemInform. 31

The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1365fe87d6ce4bb02178259443de41ab
https://doi.org/10.1002/chin.200006094

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Synthesis and Binding Affinity to Human ? and ? Estrogen Receptors of Various 7-Hydroxycoumarins Substituted at 4- and 3,4-Positions

Autor: Serge Kirkiacharian, Evelyne Cerede, Anh Tuan Lormier, Francoise Bouchoux, Henri Chidiack

Publikováno v: ChemInform. 36

The study of the relative binding affinity (RBA) to the human α and β estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERα and ERβ. The 4-(4-hydroxyphenyl)-7-hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc109a0f54580f7e4437590b03469675
https://doi.org/10.1002/chin.200516124

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Synthesis and Relative Binding Affinity to Human Steroid Receptors of Substituted 3-Aryloxycoumarins

Autor: Serge Kirkiacharian, Francoise Bouchoux, Francois Terrier, Evelyne Cerede, Michele Resche‐Rigon, Robert Bakhchinian

Publikováno v: ChemInform. 35

The synthesis of a set of substituted 3-aryloxycoumarins was performed. The study of the relations between their structure and their relative binding affinity to human androgen, progesterone, α and β estrogen receptors was achieved.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5c43faaa678432fee166743cc8758c
https://doi.org/10.1002/chin.200409113

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