Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Francoise Berlioz-Seux"'
Autor:
Brinley Furey, Francoise Berlioz-Seux, Irina Nikolaevna Kadiyala, Rebecca S. Shawgo, Rima Patel, Patricia Hurter, Michael Briggs, Diane M. Boucher, Howard Li, Karem Reda, Kirk Tanner
Publikováno v:
Journal of Pharmaceutical Sciences. 107:856-862
The reported proof of principle study demonstrated the feasibility of local delivery of a c-Met inhibitor (VXc-140) in a subcutaneous xenograft tumor model. VXc-140 was formulated in a wafer delivery system for direct implantation into the tumor. Sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb61e8a5622a7f2e87ff2b078c2cd75e
https://doi.org/10.1016/j.xphs.2017.10.025
https://doi.org/10.1016/j.xphs.2017.10.025
Autor:
Hamilton B. Bennett, Paul S. Charifson, Michael P. Clark, Rene Rijnbrand, Colleen F. McNeil, Joshua R. Leeman, Alice W. Tsai, Cassey Huang, Randal Byrn, Nti-Addae Kwame Wiredu, Jones Steven, Francoise Berlioz-Seux, Ursula A. Germann
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:6007-6016
Through antigenic drift and shifts, influenza virus infections continue to be an annual cause of morbidity in healthy populations and of death among elderly and at-risk patients. The emergence of highly pathogenic avian influenza viruses such as H5N1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1710f9750418fb421faa6ad9a7ab7c6d
https://doi.org/10.1128/aac.00781-15
https://doi.org/10.1128/aac.00781-15
Autor:
Simon Giroux, Nigel Ewing, Youssef L. Bennani, Francoise Berlioz-Seux, Rebecca S. Shawgo, Anne-Laure Grillot, Nathalie Chauret, Kevin M. Cottrell, Laval C. Chan, Evelyne Dietrich, Francois Denis, Morris Mark A, John Maxwell, Sanjoy Kumar Das, Lucille L’Heureux, Darius Bilimoria, T. Jagadeeswar Reddy, Subajini Selliah, Caroline Cadilhac, Olivier Nicolas, Jinwang Xu, James A. Henderson, Nagraj Mani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:936-939
The discovery of C2-symmetric bis-thienoimidazoles HCV NS5A inhibitors is herein reported. Two straightforward approaches to access the requisite diyne and biphenyl linker moieties are described. This study revealed the paramount importance of the ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597bec3afadcf6a330d92543b0a8f6ee
https://doi.org/10.1016/j.bmcl.2014.12.046
https://doi.org/10.1016/j.bmcl.2014.12.046
Autor:
Jian Wang, Anne-Laure Grillot, Carl Poisson, Simon Giroux, Nigel Ewing, Youssef L. Bennani, Rebecca S. Shawgo, Ronald Grey, Louis Vaillancourt, Nathalie Chauret, Darius Bilimoria, Olivier Nicolas, Lucille L’Heureux, Subajini Selliah, Kevin M. Cottrell, B. Govinda Rao, Constantin Yannopoulos, Guy Falardeau, Monica Bubenik, Laval C. Chan, James A. Henderson, Sanjoy Kumar Das, Francois Denis, T. Jagadeeswar Reddy, Caroline Cadilhac, Morris Mark A, Oswy Z. Pereira, Evelyne Dietrich, Nagraj Mani, John Maxwell, Francoise Berlioz-Seux, Bingcan Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The treatment of HCV with highly efficacious, well-tolerated, interferon-free regimens is a compelling clinical goal. Trials employing combinations of direct-acting antivirals that include NS5A inhibitors have shown significant promise in meeting thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e4ebe2d070d70ea590c6cfa7ac65e5
https://pubmed.ncbi.nlm.nih.gov/25577041
https://pubmed.ncbi.nlm.nih.gov/25577041
Autor:
Anne-Laure Grillot, Nigel Ewing, Youssef L. Bennani, Simon Giroux, Nathalie Chauret, Caroline Cadilhac, Kevin M. Cottrell, Olivier Nicolas, T. Jagadeeswar Reddy, Evelyne Dietrich, Lucille L’Heureux, Francois Denis, Oswy Z. Pereira, Rebecca S. Shawgo, Jinwang Xu, Nagraj Mani, Francoise Berlioz-Seux, Jian Wang, Sanjoy Kumar Das, John Maxwell, Bingcan Liu, James A. Henderson, Louis Vaillancourt, Subajini Selliah, Guy Falardeau, Laval C. Chan, Morris Mark A, Carl Poisson, Darius Bilimoria, Monica Bubenik
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
Inhibitors of the HCV NS5A nonstructural protein are showing promising clinical potential in the treatment of hepatitis C when used in combination with other direct-acting antiviral agents. Current NS5A clinical candidates such as daclatasvir, ledipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7cd5e136e04d9531ebb95d47a5b4ba
https://pubmed.ncbi.nlm.nih.gov/25577039
https://pubmed.ncbi.nlm.nih.gov/25577039
Autor:
John Maxwell, Francois Denis, Kevin M. Cottrell, Francoise Berlioz-Seux, Subajini Selliah, Rebecca S. Shawgo, Nigel Ewing, Youssef L. Bennani, Morris Mark A, Anne-Laure Grillot, Laval C. Chan, Simon Giroux, Darius Bilimoria, Nagraj Mani, Caroline Cadilhac, T. Jagadeeswar Reddy, James A. Henderson, Olivier Nicolas, Sanjoy Kumar Das, Nathalie Chauret, Jinwang Xu, Lucille L’Heureux, Evelyne Dietrich
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The discovery of non-symmetric thienoimidazole-containing HCV NS5A inhibitors is described. The inhibitors herein reported display high potencies against both genotype 1a and 1b. In this follow-up manuscript, we discuss the importance of the linker a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2653e538bf9676e04cefdff02bc3f577
https://pubmed.ncbi.nlm.nih.gov/25597006
https://pubmed.ncbi.nlm.nih.gov/25597006
Autor:
Nathalie Chauret, Francoise Berlioz-Seux, Anne-Laure Grillot, Nigel Ewing, Sanjoy Kumar Das, Jinwang Xu, Oliver Nicolas, James A. Henderson, Youssef L. Bennani, Darius Bilimoria, Simon Giroux, Francois Denis, John Maxwell, Caroline Cadilhac, Morris Mark A, Mark N. Namchuk, Nagraj Mani, Laval C. Chan, Lucille L’Heureux, Subajini Selliah, T. Jagadeeswar Reddy, Rebecca S. Shawgo, Kevin M. Cottrell
The discovery of potent thienoimidazole-based HCV NS5A inhibitors is herein reported. A novel method to access the thienoimidazole [5,5]-bicyclic system is disclosed. This method gave access to a common key intermediate (6) that was engaged in Suzuki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6659bdfa639f80381f726c3da883bd65
https://europepmc.org/articles/PMC4027595/
https://europepmc.org/articles/PMC4027595/
Autor:
Donald Hodges, Joseph Prezioso, Ursula A. Germann, Kirk Tanner, Hong Gao, Doris Damian, Francoise Berlioz-Seux, Malar Pannirselvam
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:e45-e46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1a4f22504564affa0b067cabbbf6cb
https://doi.org/10.1016/j.vascn.2013.01.164
https://doi.org/10.1016/j.vascn.2013.01.164