Dynamic Behavior of Polymer Microbubbles During Long Ultrasound Tone-Burst Excitation and Its Application for Sonoreperfusion Therapy

Autor: Xianghui Chen, Xucai Chen, Jianjun Wang, Francois T.H. Yu, Flordeliza S. Villanueva, John J. Pacella

Publikováno v: Ultrasound in Medicine & Biology. 49:996-1006

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::837e05a9e99d98b2d0c29d0a7667d351
https://doi.org/10.1016/j.ultrasmedbio.2022.12.013

The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer

Autor: Balasubramanian Sellamuthu, Marie Amate, Francois T.H. Yu, Joseph Goldgewicht, John Stagg

Publikováno v: Nanotheranostics

In solid tumors, the limited diffusion of therapeutic molecules in the perivascular space is a known limitation impacting treatment efficacy. Ultrasound Targeted Microbubble Cavitation (UTMC) has been shown to increase vascular permeability and impro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9018fcc8049950976c610fb0316447c
https://doi.org/10.7150/ntno.46892

Localized release of extracellular ATP by ultrasound and microbubbles for enhancing cancer immunotherapy

Autor: B. Sellamuthu, Falonne Demeze Kenfack, Andrea Shima, Francois T.H. Yu

Publikováno v: 2020 IEEE International Ultrasonics Symposium (IUS).

Introduction: Extracellular ATP (eATP) is a damage-associated molecular pattern (DAMP) which plays a critical role in the activation of the NLRP3 inflammasome, an important mediator of the innate immune response. Ultrasound (US) and microbubbles (MB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79bae0c51ee2687feee783f0bed3a8f6
https://doi.org/10.1109/ius46767.2020.9251556

Inertial Cavitation Ultrasound with Microbubbles Improves Reperfusion Efficacy When Combined with Tissue Plasminogen Activator in an In Vitro Model of Microvascular Obstruction

Autor: Andrew D. Althouse, Akash Goyal, John J. Pacella, Mathea G. Tenwalde, Francois T.H. Yu, Flordeliza S. Villanueva, Xucai Chen

Publikováno v: Ultrasound in Medicine & Biology. 43:1391-1400

We have previously reported that long-tone-burst, high-mechanical-index ultrasound (US) and microbubble (MB) therapy can restore perfusion in both in vitro and in vivo models of microvascular obstruction (MVO). Addition of MBs to US has been found to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20450c4e8d05fedd5f47bb163ae3f8a
https://doi.org/10.1016/j.ultrasmedbio.2017.02.013

SONOREPERFUSION THERAPY KINETICS IN WHOLE BLOOD USING ULTRASOUND, MICROBUBBLES AND TISSUE PLASMINOGEN ACTIVATOR

Autor: Sebastiaan T. Roos, Xucai Chen, John J. Pacella, Francois T.H. Yu, Flordeliza S. Villanueva, Otto Kamp

Publikováno v: Ultrasound in Medicine and Biology, 42(12), 3001-3009. Elsevier USA
Roos, S T, Yu, F T, Kamp, O, Chen, X, Villanueva, F S & Pacella, J J 2016, ' SONOREPERFUSION THERAPY KINETICS IN WHOLE BLOOD USING ULTRASOUND, MICROBUBBLES AND TISSUE PLASMINOGEN ACTIVATOR ', Ultrasound in Medicine and Biology, vol. 42, no. 12, pp. 3001-3009 . https://doi.org/10.1016/j.ultrasmedbio.2016.08.013

Coronary intervention for myocardial infarction often results in microvascular embolization of thrombus. Sonoreperfusion therapy (SRP) using ultrasound and microbubbles restored perfusion in our in vitro flow model of microvascular obstruction. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0b1c4780b8690a543d6a2c2090e28d
https://doi.org/10.1016/j.ultrasmedbio.2016.08.013