Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francois T. Bruderlein"'
Publikováno v:
Canadian Journal of Chemistry. 52:2119-2122
Two synthetic routes to (±)-(4a,13b-trans)-2,3,4,4a,8,9,13b,14-octahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinoline hydrochloride (1) (taclamine hydrochloride) are described. Configurational assignments have been made on the basis of
Publikováno v:
Journal of Medicinal Chemistry. 21:1225-1231
The synthesis of analogues of the antipsychotic drug butaclamol bearing chloro substituents on the benzene rings is described. On the basis of a perceived topographical similarity of a putative chlorophenylethylamine pharmacophore present in these an
Publikováno v:
Chemischer Informationsdienst. 10
The synthesis of analogues of the antipsychotic drug butaclamol bearing chloro substituents on the benzene rings is described. On the basis of a perceived topographical similarity of a putative chlorophenylethylamine pharmacophore present in these an
Publikováno v:
ACS Symposium Series ISBN: 9780841205215
Computer-Assisted Drug Design
Computer-Assisted Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30ea994be2fd80ebe95be8b06c9131f
https://doi.org/10.1021/bk-1979-0112.ch010
https://doi.org/10.1021/bk-1979-0112.ch010
Publikováno v:
Chemischer Informationsdienst. 9
The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The animal models were predictive of neuroleptic activity as well as side effects commonly associated with neuroleptic thera
Publikováno v:
Chemischer Informationsdienst. 5
Two synthetic routes to (±)-(4a,13b-trans)-2,3,4,4a,8,9,13b,14-octahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinoline hydrochloride (1) (taclamine hydrochloride) are described. Config...
Publikováno v:
Chemischer Informationsdienst. 10
Publikováno v:
Journal of medicinal chemistry. 22(7)
Several analogues of the neuroleptic agent butaclamol, having modifications in the ring E region of the molecule, have been synthesized. Pharmacological evaluation identified two of the analogues as being equipotent to butaclamol, namely, anhydrobuta
Publikováno v:
Chemischer Informationsdienst. 6
Publikováno v:
Journal of medicinal chemistry. 18(2)
The syntheses and the structural and stereochemical requirements for antagonism of (+)-amphetamine-induced sterotypy are described for a series of benzocycloheptapyridoisoquinoline derivatives. One of these compounds, (plus or minus)-(4a,13b-trans)[3