Red blood cell metabolomics identify ergothioneine as a key metabolite in DMARD-naïve rheumatoid arthritis and response to methotrexate

Autor: Johanna Sigaux, Christophe Junot, Marie-Christophe Boissier, Mylène Petit, Magali Breckler, Florence Castelli, François Fenaille, Paul-Henri Roméo, Luca Semerano

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)

Abstract Using a new red blood cell (RBC) metabolite extraction protocol, we performed a metabolomic analysis on RBCs in rheumatoid arthritis (RA) patients treated or not with methotrexate (MTX), with the two following objectives: to compare the RBC

Externí odkaz: https://doaj.org/article/70f13b2d3953432ba82a48b514092aa6

MilkOligoThesaurus, a dataset of mammalian milk oligosaccharide synonyms

Autor: Mathilde Rumeau, François Fenaille, Agnès Girard, Valentin Loux, Mouhamadou Ba, Claire Nédellec, Louise Deléger, Robert Bossy, Sophie Aubin, Christelle Knudsen, Sylvie Combes

Publikováno v: Data in Brief, Vol 54, Iss , Pp 110404- (2024)

There is a growing interest in milk oligosaccharides (MOs) because of their numerous benefits for newborns’ and long-term health. A large number of MO structures have been identified in mammalian milk. Mostly described in human milk, the oligosacch

Externí odkaz: https://doaj.org/article/c79bce06a41d44c9a72ed220ed3de47a

Uveitic glaucoma-like features in Yap conditional knockout mice

Autor: Juliette Bitard, Elodie-Kim Grellier, Sophie Lourdel, Helena Prior Filipe, Annaïg Hamon, François Fenaille, Florence Anne Castelli, Emeline Chu-Van, Jérôme E. Roger, Morgane Locker, Muriel Perron

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Abstract Glaucoma is a multifactorial neurodegenerative disease characterized by the progressive and irreversible degeneration of the optic nerve and retinal ganglion cells. Despite medical advances aiming at slowing degeneration, around 40% of treat

Externí odkaz: https://doaj.org/article/5094564ec34949d59e846b3ed1d20852

Insights from metabolomic and molecular signatures to detect, in a blood sample, muscle anabolic resistance associated with catabolic situation. Case model of glucocorticoids effect in mini-pigs

Autor: Sergio Polakof, Marie Tremblay-Franco, Nathalie Poupin, Florence Castelli, Jérémie David, Marianne Jarzaguet, Didier Rémond, Francois Fenaille, Dominique Dardevet

Publikováno v: Fifth International Congress of Translational Research in Human Nutrition (ICTRHN)
Fifth International Congress of Translational Research in Human Nutrition (ICTRHN), Jun 2019, Clermont-Ferrand, France
HAL

ICTRHN Nutrition, Physical activity and health Oral communication SESSION 2: MUSCLE WASTING AND ORGAN FAILURE ICTRHN Nutrition, Physical activity and health Oral communication SESSION 2: MUSCLE WASTING AND ORGAN FAILUREICTRNH Nutrition, Physical acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e7e8960ae8ad4e629ca8555c4d41b7a6
https://hal.archives-ouvertes.fr/hal-02154641

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial

Autor: Torben Hansen, Pere Ginès, Wim Laleman, Peer Bork, Vishal C Patel, Debbie Shawcross, Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam, Ed J Kuijper, Frank Erhard Uschner, Michael Praktiknjo, Mária Papp, Saeed Shoaie, Michael Kühn, Maja Thiele, Paolo Angeli, Joan Claria, Vicente Arroyo, Manolo Laiola, Benoit Quinquis, Sabine Klein, Minneke J Coenraad, François Fenaille, Debbie Lindsay Shawcross, Wenyi Gu, Adria Juanola, Elisa Pose, Aleksander Krag, Ivica Letunic, Alain Pruvost, Hervé M Blottière, Nathalie Galleron, Cristina López-Vicario, Peter V Treit, Matthias Mann, Jelle Matthijnssens, Mark J W Mcphail, Philipp E Geyer, Hans Olav Melberg, Stefanie Kandels, Cristina Sánchez-Garrido, Florence A Castelli, Christophe Junot, Lars Asphaug, Mads Israelsen, Helene Bæk Juel, Nikolaj Torp, Minneke Coenraad, Marko Korenjak, Ferran Aguilar-Parera, Patricia Sierra-Casas, Anna Bosch-Comas, David Tornai, Boglarka Balogh, Katrine Holtz Thorhauge, Casper Sahl Poulsen, Thea Van Rossum, Suguru Nishijima, Marisa I Keller, Diënty H M Hazenbrink, Sylvain Dechaumet, Sebastian D Burz, Emeline Chu-Van, Etienne Thévenot, Florian A Rosenberger, Sebastian Van Blerk, Amirouche Ouzerdine, Alain Roulet, Jean-Louis-Marie Insonere, Céline Serres, Mathieu Almeida, Florence Thirion, Camille Champion, Chaima Ezzine, Célia Chamignon, Nicolas Lapaque, Mamadou Gabou Thiam, Lore Van Espen, Quinten R Ducarmon, Annelotte GC Broekhoven, Susan Fischer, Romy Zwittink, Itziar De Lecuona, Giulio Rosati, Celia Fuentes-Chust, Arben Merkoçi, Massimo Urban, José Alfonso Marrugo-Ramirez, Ameli Schwalber, Lindsey Ann Edwards, Victoria Tatiana Kronsten, David Moyes, Azadeh Harzandi, Jordi Gratacós-Ginès, Martina Pérez-Guasch, Miriam Pellón, Bryan Contreras, Max Brol, Manfred Fobker, Renata Antonina Feuerborn

Publikováno v: BMJ Open, Vol 14, Iss 2 (2024)

Introduction Human albumin is used in the treatment of complications of cirrhosis. However, the use of long-term human albumin administration is costly and resource demanding for both patients and healthcare systems. A precision medicine approach wit

Externí odkaz: https://doaj.org/article/289f12a27d2047adb5cb758cb2809703