Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Francois Brial"'
Autor:
Pierre Zalloua, Hanane Kadar, Essa Hariri, Layal Abi Farraj, Francois Brial, Lyamine Hedjazi, Aurelie Le Lay, Alexandre Colleu, Justine Dubus, David Touboul, Fumihiko Matsuda, Mark Lathrop, Jeremy K. Nicholson, Marc-Emmanuel Dumas, Dominique Gauguier
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis and myocardial infarction. Epidemiological, genetic and experimental observations have implicated the associ
Externí odkaz:
https://doaj.org/article/0f841e838d45496fa533e172b6df96fa
Autor:
Francois Brial, Lyamine Hedjazi, Kazuhiro Sonomura, Cynthia Al Hageh, Pierre Zalloua, Fumihiko Matsuda, Dominique Gauguier
Publikováno v:
Metabolites, Vol 12, Iss 7, p 596 (2022)
Analysis of the genetic control of small metabolites provides powerful information on the regulation of the endpoints of genome expression. We carried out untargeted liquid chromatography–high-resolution mass spectrometry in 273 individuals charact
Externí odkaz:
https://doaj.org/article/5178b793c8164b74b99fd79580f85605
Autor:
Francois Brial, Fawaz Alzaid, Kazuhiro Sonomura, Yoichiro Kamatani, Kelly Meneyrol, Aurélie Le Lay, Noémie Péan, Lyamine Hedjazi, Taka-Aki Sato, Nicolas Venteclef, Christophe Magnan, Mark Lathrop, Marc-Emmanuel Dumas, Fumihiko Matsuda, Pierre Zalloua, Dominique Gauguier
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2306-2320.e5 (2020)
Summary: Exposure to natural metabolites contributes to the risk of cardiometabolic diseases (CMDs). Through metabolome profiling, we identify the inverse correlation between serum concentrations of 4-cresol and type 2 diabetes. The chronic administr
Externí odkaz:
https://doaj.org/article/32e9beb218a54a328a3b0c228d5df1d6
Autor:
Cynthia Al Hageh, Ryan Rahy, Georges Khazen, Francois Brial, Rony S Khnayzer, Dominique Gauguier, Pierre A Zalloua
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242019 (2020)
Aortic valve stenosis (AVS) is a prevalent condition among the elderly population that eventually requires aortic valve replacement. The lack of reliable biomarkers for AVS poses a challenge for its early diagnosis and the application of preventive m
Externí odkaz:
https://doaj.org/article/9e009dfacb604c45af2f20f22206bf66
Autor:
Lesley Hoyles, Maria L. Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R. Gibson, Jeremy D. Sanderson, Jeremy K. Nicholson, Dominique Gauguier, Anne L. McCartney, Marc-Emmanuel Dumas
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA). However, little is known about the use of trimethylamine N-oxid
Externí odkaz:
https://doaj.org/article/03479cc65b71470e90c9d21a08eb262c
Autor:
Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from th
Externí odkaz:
https://doaj.org/article/d979937a0bc24797ae8857c1bcbbda14
Publikováno v:
Biochimie. 194:35-42
The gut microbiota contributes to mammalian host biology by supplying metabolites from nutrients and pro-inflammatory molecules. We have recently shown that urinary hippurate is associated with reduced risk of obesity, increased gut microbiome divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42865cd95ab790298dfc7b3beae014ba
https://doi.org/10.1016/j.biochi.2021.12.010
https://doi.org/10.1016/j.biochi.2021.12.010
Autor:
Petros Andrikopoulos, Fatima Djouadi, Lesley Hoyles, Trine Nielsen, Matej Orešič, Karine Clément, Nicolas Pons, Andrea Rodriguez-Martinez, Sofia K. Forslund, Gwen Falony, Francois Brial, Stanislav Dusko Ehrlich, Tuulia Hyötyläinen, Dominique Gauguier, Peer Bork, Marc-Emmanuel Dumas, Michael Olanipekun, Ana Luisa Neves, Jeroen Raes, Julien Chilloux, Jeremy K. Nicholson, Sara Vieira-Silva, Torben Hansen, Emmanuelle Le-chatelier, Aurélie Le Lay, Oluf Pedersen, Ghiwa Ishac Mouawad
Publikováno v:
Gut
Gut, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Gut, BMJ Publishing Group, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P, Olanipekun, M, Hoyles, L, Djouadi, F, Neves, A L, Rodriguez-Martinez, A, Mouawad, G I, Pons, N, Forslund, S, Le-chatelier, E, Le Lay, A, Nicholson, J, Hansen, T, Hyotylainen, T, Clement, K, Oresic, M, Bork, P, Ehrlich, S D, Raes, J, Pedersen, O B, Gauguier, D & Dumas, M-E 2021, ' Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health ', Gut, vol. 70, no. 11, pp. 2105-2114 . https://doi.org/10.1136/gutjnl-2020-323314
Gut, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Gut, BMJ Publishing Group, 2021, 70 (11), pp.2105-2114. ⟨10.1136/gutjnl-2020-323314⟩
Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P, Olanipekun, M, Hoyles, L, Djouadi, F, Neves, A L, Rodriguez-Martinez, A, Mouawad, G I, Pons, N, Forslund, S, Le-chatelier, E, Le Lay, A, Nicholson, J, Hansen, T, Hyotylainen, T, Clement, K, Oresic, M, Bork, P, Ehrlich, S D, Raes, J, Pedersen, O B, Gauguier, D & Dumas, M-E 2021, ' Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health ', Gut, vol. 70, no. 11, pp. 2105-2114 . https://doi.org/10.1136/gutjnl-2020-323314
ObjectiveGut microbial products are involved in regulation of host metabolism. In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d9d81ce9f99ebb92c836853b611c64
https://cnrs.hal.science/hal-03451210
https://cnrs.hal.science/hal-03451210
Autor:
Gwen Falony, Ghiwa Ishac Mouawad, Trine Nielsen, Jeremy K. Nicholson, Jeroen Raes, Lesley Hoyles, Karine Clément, Oluf Pedersen, Sofia K. Forslund, Ana Luisa Neves, Aurélie M. Le Lay, Francois Brial, Julien Chilloux, Peer Bork, Andrea Rodriguez-Martinez, S. Dusko Ehrlich, Marc-Emmanuel Dumas, Nicolas Pons, Sara Vieira-Silva, Torben Hansen, Dominique Gauguier
ObjectiveGut microbial products are involved in type 2 diabetes, obesity and insulin resistance. In particular, hippurate, a hepatic phase 2 conjugation product of microbial benzoate metabolism, has been associated with a healthy phenotype. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d924084303c0cdf516ba270ca4da2bd
http://edoc.mdc-berlin.de/18619/1/18619oa.pdf
http://edoc.mdc-berlin.de/18619/1/18619oa.pdf
Autor:
Richard Mott, Georg W. Otto, Aurélie Le Lay, Dominique Gauguier, Francois Brial, Jean-Baptiste Cazier, Pamela J. Kaisaki
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b3ec2e92f20786c6057a480f6c9ebb
https://pubmed.ncbi.nlm.nih.gov/31213483
https://pubmed.ncbi.nlm.nih.gov/31213483