Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Francois Binette"'
Autor:
Paige A. Winkler, Ratnesh K. Singh, Francois Binette, Simon M. Petersen-Jones, Igor O. Nasonkin
Publikováno v:
Stem Cells Dev
Progressive vision loss, caused by retinal degenerative (RD) diseases such as age-related macular degeneration, retinitis pigmentosa, and Leber congenital amaurosis, severely impacts quality of life and affects millions of people. Finding efficient t
Autor:
Francois Binette, Maria M Campos, Thomas I. Zarembinski, Michael O'Boyle, Igor O. Nasonkin, Ratnesh K. Singh, Randolph D. Glickman, Michael Onorato
Publikováno v:
J Ocul Pharmacol Ther
Purpose: To determine the long-term biocompatibility of HyStem(®) hydrogel in the rabbit eye for use as a carrier for cell or drug delivery into the ocular space. Methods: HyStem hydrogel formulation solidifies ∼20 min after reconstitution, thus c
Autor:
Igor O. Nasonkin, Paige A. Winkler, Randolph D. Glickman, Ratnesh K. Singh, Francois Binette, Simon M. Petersen-Jones, Magdalene J. Seiler
Publikováno v:
J Tissue Eng Regen Med
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and
Autor:
Igor O. Nasonkin, Ratnesh K. Singh, Simon M. Petersen-Jones, Laurence M. Occelli, Francois Binette, Felipe Marinho
Publikováno v:
J Vis Exp
Retinal degenerative (RD) conditions associated with photoreceptor loss such as age-related macular degeneration (AMD), retinitis pigmentosa (RP) and Leber Congenital Amaurosis (LCA) cause progressive and debilitating vision loss. There is an unmet n
Autor:
Igor O. Nasonkin, Simon M. Petersen-Jones, Francois Binette, Ratnesh K. Singh, Laurence M. Occelli
Publikováno v:
Stem Cells and Development
To develop biological approaches to restore vision, we developed a method of transplanting stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat). Human embryonic stem cells (hESC) were differentiated to retinal
Autor:
Ratnesh K. Singh, Paige Winkler, Francois Binette, Randolph D. Glickman, Magdalene Seiler, Simon M. Petersen‐Jones, Igor O. Nasonkin
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 14
Autor:
Francois Binette, Michael D. West, Hal Sternberg, Oscar Cuzzani, Igor O. Nasonkin, Ratnesh K. Singh
Publikováno v:
Stem Cell Reviews
The retina is a very fine and layered neural tissue, which vitally depends on the preservation of cells, structure, connectivity and vasculature to maintain vision. There is an urgent need to find technical and biological solutions to major challenge
Autor:
Hal Sternberg, Charles Irving, Francois Binette, Michael D. West, David Larocca, Karen B. Chapman
Publikováno v:
Regenerative Medicine. 11:331-334
Human somatic cells are mortal due in large part to telomere shortening associated with cell division. Limited proliferative capacity may, in turn, limit response to injury and may play an important role in the etiology of age-related pathology. Plur
Publikováno v:
Journal of Visualized Experiments : JoVE
The epigenetics of retinal development is a well-studied research field, which promises to bring a new level of understanding about the mechanisms of a variety of human retinal degenerative diseases and pinpoint new treatment approaches. The nuclear
Autor:
Ron Edgar, Alina Shitrit, Francois Binette, Karen B. Chapman, Hal Sternberg, Jianjie Jiang, Pamela Sim, Jennifer Kidd, Michael D. West, David Larocca, Jeffrey Janus, Ariel Rinon
Publikováno v:
Regenerative Medicine. 9:53-66
Aims: The transcriptome and fate potential of three diverse human embryonic stem cell-derived clonal embryonic progenitor cell lines with markers of cephalic neural crest are compared when differentiated in the presence of combinations of TGFβ3, BMP