Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Francois Bellamy"'
Publikováno v:
Urology. 61:474-478
Objectives Pretreatment with oral tadenan (TAD) has been shown to possess a protective effect on bladder dysfunction-induced obstruction. We evaluated the functional influence of cotreatment and post-treatment with oral TAD on the frequency/volume ch
Autor:
Robert M. Levin, P. A. T. Horan, Pak Ham Chow, Francois Bellamy, John A. Gosling, Katherine Whitbeck, Lai Sin Kung, Martha A. Hass
Publikováno v:
Scopus-Elsevier
There is increasing evidence that the progressive dysfunction induced by partial outlet obstruction is mediated by ischemia-reperfusion, and bladder decompensation results from ischemia-reperfusion induced damage to the cellular and subcellular organ
Autor:
Takeo Matsukura, Jean Claude Ortuno, Shigeo Ohbayashi, Alan D Edgar, Jean Binet, Akihiro Matsuura, Thierry Laugel, Paul Padovani, Christiane Legendre, Christian Guffroy, Stéphane Perrey, Francois Bellamy, Toshiya Tanaka
Publikováno v:
Atherosclerosis. 155:359-370
The cholesteryl ester, foam cell-enriched vulnerable plaque is a principle pharmacological target for reducing athero-thrombosis. Acyl CoA:cholesterol Acyl Transferase (ACAT) catalyzes the esterification of free cholesterol in intestine, liver, adren
Fenofibrate protects lipoproteins from lipid peroxidation: Synergistic interaction with α-tocopherol
Publikováno v:
Lipids. 34:497-502
One of the earliest steps of atherosclerotic plaque formation is an increase of circulating apolipoprotein B-containing lipoproteins which, after infiltrating the subendothelial space, undergo oxidative modification. Fenofibrate is an effective chole
Publikováno v:
Carbohydrate Research. 316:104-111
Treatment of the 2,3-isopropylidene acetal of the title dithioxyloside with 2,4,5-triiodoimidazole-PPh3 caused replacement of the 4-hydroxyl group by iodine to afford 82% of the 4-axial iodide 6, converted by base into 4-cyanophenyl 2,3-O-isopropylid
Publikováno v:
Carbohydrate Research. 314:161-167
The title dithioxyloside 1 , an orally active antithrombotic agent, as its 2,3-isopropylidene acetal, was converted into the corresponding glycos-4-ulose, which served as precursor via reduction to the 4-epimer of 1 and via oximation–reduction to t
Autor:
Francois Bellamy, Jean Millet, Niall Martin, Jocelyne Theveniaux, Christiane Sepulchre, Philippe Masson
Publikováno v:
Seminars in Thrombosis and Hemostasis. 22:247-254
Following a screening program for orally active antithrombotic drugs, it was found that a series of thioxyloside compounds presented with good venous antithrombotic properties. Of more than 500 compounds, LF 09-0055, LF 04-0212, and LF 05-0030 were t
Autor:
Lev Krasnopolsky, Francois Bellamy, Yang Zhao, Robert M. Levin, J.-P. Riffaud, Mohamed Habib, Alan J. Wein, Dorothea Rohrmann
Publikováno v:
Journal of Urology. 155:1466-1470
Purpose: Tadenan (DEBAT, Paris, France) is a pharmaceutical agent used in the treatment of benign prostatic hyperplasia (BPH). The specific aim of this study was to determine if pretreatment of rabbits with Tadenan reduced either the hypertrophic res
Publikováno v:
Carbohydrate Research. 249:39-48
The title glycoside undergoes acetonation with 2-methoxypropene to give a 2:1 mixture of the crystalline 2,3- and 3,4-isopropylidene acetals in 94% yield, which upon methylation under controlled conditions followed by deacetonation afforded the respe
Autor:
Derek Horton, Jean Bernard Chazan, Francois Bellamy, Millet Jean, Francois Picart, Soth Samreth
Publikováno v:
Journal of Medicinal Chemistry. 36:898-903
A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an