Výsledky vyhledávání - "Francois, Bordeleau"

Akademický článek

Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA

Autor: Wenjun Wang, Paul V. Taufalele, Martial Millet, Kevin Homsy, Kyra Smart, Emily D. Berestesky, Curtis T. Schunk, Matthew M. Rowe, Francois Bordeleau, Cynthia A. Reinhart-King

Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112338- (2023)

Summary: During intravasation, cancer cells cross the endothelial barrier and enter the circulation. Extracellular matrix stiffening has been correlated with tumor metastatic potential; however, little is known about the effects of matrix stiffness o

Externí odkaz: https://doaj.org/article/7fdc709fb6454d83b7c97e3b8661d0fc

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Akademický článek

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

Autor: Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King

Publikováno v: eLife, Vol 11 (2022)

Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with w

Externí odkaz: https://doaj.org/article/622c88bf6fa14684a1a8c69fe64f0098

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Akademický článek

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Autor: Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jacob A. VanderBurgh, Paul V. Taufalele, Aadhar Jain, David Erickson, Francois Bordeleau, Cynthia A. Reinhart-King

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinemen

Externí odkaz: https://doaj.org/article/d89947d85d604810a3c24366f9f1743c

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Akademický článek

Improving fascin inhibitors to block tumor cell migration and metastasis

Autor: Shaoqin Han, Jianyun Huang, Bingqian Liu, Bowen Xing, Francois Bordeleau, Cynthia A. Reinhart-King, Wenxin Li, J. Jillian Zhang, Xin-Yun Huang

Publikováno v: Molecular Oncology, Vol 10, Iss 7, Pp 966-980 (2016)

Tumor metastasis is the major cause of mortality of cancer patients, being responsible for ∼90% of all cancer deaths. One of the key steps during tumor metastasis is tumor cell migration which requires actin cytoskeletal reorganization. Among the c

Externí odkaz: https://doaj.org/article/3c6aa1559fc64dbe851d5e4d20f47ae8

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