Výsledky vyhledávání - "Franco Puleo"

Akademický článek

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich’s Ataxia

Autor: Ryan J. McGinty, Franco Puleo, Anna Y. Aksenova, Julia A. Hisey, Alexander A. Shishkin, Erika L. Pearson, Eric T. Wang, David E. Housman, Claire Moore, Sergei M. Mirkin

Publikováno v: Cell Reports, Vol 20, Iss 10, Pp 2490-2500 (2017)

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. Whereas the length of an expandable repeat is the main factor determining disease inheritance, re

Externí odkaz: https://doaj.org/article/0dfcf17ded7242c7a59c4d6e7f1ea13e

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Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gαi 2 protein‐dependent, salt‐sensitive hypertension

Autor: Tara L. Moore, Alissa A. Frame, Kayla M. Nist, Parul Chaudhary, Franco Puleo, Richard D Wainford, Jesse D. Moreira, Eric Abkin, Jonique C. George

Publikováno v: Experimental Physiology

New findings • What is the central question of this study? We hypothesized that central inflammatory processes that involve activation of microglia and astrocytes contribute to the development of Gαi2 protein-dependent, salt-sensitive hypertension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ba3ccd72c3789cc11596178f7de5f7
https://doi.org/10.1113/ep087924

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Sympathetic Regulation of the NCC (Sodium Chloride Cotransporter) in Dahl Salt-Sensitive Hypertension

Autor: Eric Abkin, Franco Puleo, Erica Comsti, Jesse D. Moreira, Alissa A. Frame, Kiyoung Kim, Mohammed Z. Ferdaus, Richard D Wainford, Kayla M. Nist, Kathryn R Walsh, Elizabeth Faudoa

Publikováno v: Physiol Res

Increased sympathoexcitation and renal sodium retention during high salt intake are hallmarks of the salt sensitivity of blood pressure. The mechanism(s) by which excessive sympathetic nervous system release of norepinephrine influences renal sodium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2116fd6c183b6c4f4e066d90b10f0d
https://pubmed.ncbi.nlm.nih.gov/33992042

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A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich’s Ataxia

Autor: Franco Puleo, Anna Y. Aksenova, Claire Moore, Julia A. Hisey, David E. Housman, Sergei M. Mirkin, Erika L. Pearson, Ryan J. McGinty, Eric T. Wang, Alexander A. Shishkin

Publikováno v: Cell Reports, Vol 20, Iss 10, Pp 2490-2500 (2017)

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. While the length of an expandable repeat is the main factor determining disease inheritance, rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6ebcc6e70d3d19e94d427452044cfc
http://www.sciencedirect.com/science/article/pii/S2211124717311762

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Abstract 055: Sex Differences in the Development of Age-Dependent Hypertension and the Salt Sensitivity of Blood Pressure

Autor: Parul Chaudhary, Richard D Wainford, Franco Puleo, Alissa A. Frame

Publikováno v: Hypertension. 74

Aim: Age-dependent hypertension (HTN) develops at different rates in men versus women. These studies tested the hypothesis that in a model of normal aging, the Sprague Dawley rat, alterations in fluid and electrolyte balance contribute to age-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfd2bac947a63d3514cd132a32cfef84
https://doi.org/10.1161/hyp.74.suppl_1.055

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Abstract 086: Pvn-Specific Microgliosis Drives Inflammation in G-Alpha-i 2 Protein Dependent Salt Sensitive Hypertension and Gnai2 Snps Correlate With Essential Hypertension

Autor: Kayla M. Nist, Jesse D. Moreira, Eric Abkin, Parul Chaudhary, Franco Puleo, Richard D Wainford, Alissa A. Frame

Publikováno v: Hypertension. 74

Aim: Failure to upregulate hypothalamic paraventricular nucleus (PVN) Gαi 2 proteins promotes salt sensitive hypertension (ssHTN) and central inflammation plays a role in HTN. We hypothesize that 1) PVN-specific inflammation contributes to Gαi 2 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0378753051dbadfffd04fad04a458a
https://doi.org/10.1161/hyp.74.suppl_1.086

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A selective impairment in the mechanosensitive afferent renal nerve‐mediated sympathoinhibitory reno‐renal reflex contributes to age‐related hypertension

Autor: Alissa A. Frame, Franco Puleo, Elizabeth Faudoa, Richard D Wainford, Jesse D. Moreira

Publikováno v: The FASEB Journal. 33

Aim The afferent renal nerves (ARN) mediate reno-renal reflexes that influence efferent renal sympathetic nerve activity, sodium homeostasis, and blood pressure. These studies tested the hypothesis...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57fa9c1771f4fa9c267473408e656cd3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.569.16

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