Výsledky vyhledávání - "Franco J. DeMayo"

Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse

Autor: Yalda Afshar, Damian Roqueiro, Franco J. DeMayo, Jae Wook Jeong, John P. Lydon, Freddy Radtke, Rachel Radnor, Asgerally T. Fazleabas, Lucio Miele

Publikováno v: The FASEB Journal. 26:282-294

Uterine receptivity implies a dialogue between the hormonally primed maternal endometrium and the free-floating blastocyst. Endometrial stromal cells proliferate, avert apoptosis, and undergo decidualization in preparation for implantation; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d740e95cf2739471e4480bd95c92999c
https://doi.org/10.1096/fj.11-184663

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Repressor of Estrogen Receptor Activity (REA) Is Essential for Mammary Gland Morphogenesis and Functional Activities: Studies in Conditional Knockout Mice

Autor: John P. Lydon, Sunghee Park, Yuechao Zhao, Sangyeon Yoon, Jianming Xu, Benita S. Katzenellenbogen, Lan Liao, Franco J. DeMayo, Bert W. O'Malley

Publikováno v: Endocrinology. 152:4336-4349

Estrogen receptor (ER) is a key regulator of mammary gland development and is also implicated in breast tumorigenesis. Because ER-mediated activities depend critically on coregulator partner proteins, we have investigated the consequences of reductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880804b0345a36db5a89335b6b002100
https://doi.org/10.1210/en.2011-1100

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Postnatal Deletion of Wnt7a Inhibits Uterine Gland Morphogenesis and Compromises Adult Fertility in Mice1

Autor: Kanako Hayashi, Edmund B. Rucker, Justyna Filant, Jian Min Deng, Jae Wook Jeong, Thomas E. Spencer, John P. Lydon, Gwonhwa Song, Kathrin A. Dunlap, Richard R. Behringer, Franco J. DeMayo

Publikováno v: Biology of Reproduction. 85:386-396

The success of postnatal uterine morphogenesis dictates, in part, the embryotrophic potential and functional capacity of the adult uterus. The definitive role of Wnt7a in postnatal uterine development and adult function requires a conditional knockou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::820a84655b01b80a38444b42ccb4fa68
https://doi.org/10.1095/biolreprod.111.091769

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Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles

Autor: Franco J. DeMayo, Linda C. Giudice, Ricardo Francalacci Savaris, A.E. Hamilton, Jeremy M. Groll, Bruce A. Lessey, Jae Wook Jeong, Steven L. Young

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 96:1737-1746

Polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women, is characterized by ovulatory dysfunction and hyperandrogenism.The aim was to compare gene expression between endometrial samples of normal fertile controls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3382ab0b91e4c898b4eca4570701eb20
https://doi.org/10.1210/jc.2010-2600

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β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus

Autor: Makoto Mark Taketo, Jae Wook Jeong, Sophia Y. Tsai, H. S. Lee, Franco J. DeMayo, Russell Broaddus, John P. Lydon, Heather L. Franco

Publikováno v: Oncogene. 28:31-40

Endometrioid adenocarcinoma is the most frequent form of endometrial cancer, usually developing in pre- and peri-menopausal women. beta-catenin abnormalities are common in endometrioid type endometrial carcinomas with squamous differentiation. To inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a047a3d8fd1dbd5496f6a8181040ce
https://doi.org/10.1038/onc.2008.363

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Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis

Autor: John P. Lydon, Bilgin Gurates, Franco J. DeMayo, Sijun Yang, Mitsutoshi Tamura, Serdar E. Bulun, Zongjuan Fang

Publikováno v: Fertility and Sterility. 82:673-678

Objective To determine the role of P and its nuclear receptor PR in the growth of ectopic uterine tissue of mice with or without a disrupted PR gene. Design Animal study. Setting Academic medical center. Animal(s) Female wild-type (WT) and transgenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34779c198e67585561414262c7d80402
https://doi.org/10.1016/j.fertnstert.2004.01.048

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CRISPR bacon: a sizzling technique to generate genetically engineered pigs

Autor: Thomas E. Spencer, Franco J. DeMayo

Publikováno v: Biology of reproduction. 91(3)

The cisgenic and transgenic capabilities of the CRISPR/Cas9 system provides important applications to create animal models and revolutionize all aspects of science in agriculture and human health.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a595b3f467b8b8438f0b20614ed74233
https://pubmed.ncbi.nlm.nih.gov/25100711

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