Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters

Autor: Margherita Festa, Velia Minicozzi, Anna Boccaccio, Laura Lagostena, Antonella Gradogna, Tianwen Qi, Alex Costa, Nina Larisch, Shin Hamamoto, Emanuela Pedrazzini, Stefan Milenkovic, Joachim Scholz-Starke, Matteo Ceccarelli, Alessandro Vitale, Petra Dietrich, Nobuyuki Uozumi, Franco Gambale, Armando Carpaneto

Publikováno v: Cells, Vol 11, Iss 6, p 921 (2022)

A distinct set of channels and transporters regulates the ion fluxes across the lysosomal membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is involved in various human diseases, such as lysosomal storage disorder

Externí odkaz: https://doaj.org/article/fdbe2428eb234230ab4b6c8065d1a986

Osmoregulated Chloride Currents in Hemocytes from Mytilus galloprovincialis.

Autor: Monica Bregante, Armando Carpaneto, Veronica Piazza, Francesca Sbrana, Massimo Vassalli, Marco Faimali, Franco Gambale

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167972 (2016)

We investigated the biophysical properties of the transport mediated by ion channels in hemocytes from the hemolymph of the bivalve Mytilus galloprovincialis. Besides other transporters, mytilus hemocytes possess a specialized channel sensitive to th

Externí odkaz: https://doaj.org/article/64789327adf4466088ceff0caf021915

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Autor: Armando Carpaneto, Antonio Filippini, Irene Pafumi, Fioretta Palombi, Francesca Papacci, Margherita Festa, Annarita Favia, Laura Lagostena, Laura Cornara, Vijay Gutla, Franco Gambale, Cristina Giunta

Publikováno v: Scientific Reports
Scientific reports (Nature Publishing Group) 7 (2017). doi:10.1038/s41598-017-04974-1
info:cnr-pdr/source/autori:Pafumi I, Festa M, Papacci F, Lagostena L, Giunta C, Gutla V, Cornara L, Favia A, Palombi F, Gambale F, Filippini A, Carpaneto A/titolo:Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis/doi:10.1038%2Fs41598-017-04974-1/rivista:Scientific reports (Nature Publishing Group)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696e4fd0ba32a283619faaec773cb41a
https://doi.org/10.1038/s41598-017-04974-1

Malate transport by the vacuolar AtALMT6 channel in guard cells is subject to multiple regulation

Autor: Joachim Scholz-Starke, Bo Burla, Enrico Martinoia, Alexis De Angeli, Franco Gambale, Stefan Meyer, Peter Kovermann

Publikováno v: The Plant Journal. 67:247-257

Gas exchange in plants is controlled by guard cells, specialized cells acting as turgor pressure-driven valves. Malate is one of the major anions accumulated inside the vacuole during stomatal opening counteracting the positive charge of potassium. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a95438a6553b41e3a8c3307c3d50973
https://doi.org/10.1111/j.1365-313x.2011.04587.x

Roles of tandem-pore K+ channels in plants - a puzzle still to be solved*

Autor: Shin Hamamoto, Ingo Dreyer, Judith Lucia Gomez-Porras, Camilla Voelker, Katrin Czempinski, Bernd Mueller-Roeber, Nobuyuki Uozumi, Dirk Becker, Franco Gambale

Publikováno v: Plant Biology. 12:56-63

The group of voltage-independent K+ channels in Arabidopsis thaliana consists of six members, five tandem-pore channels (TPK1-TPK5) and a single K-ir-like channel (KCO3). All TPK/KCO channels are located at the vacuolar membrane except for TPK4, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c7d235ac18bf6baa9465e8fed4fa264
https://doi.org/10.1111/j.1438-8677.2010.00353.x