Transcription factor protein interactomes reveal genetic determinants in heart disease

Autor: Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E.J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J.G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Publikováno v: Cell, vol 185, iss 5
Cell
Cell (Cambridge) 185 (2022): 794–814.e30. doi:10.1016/j.cell.2022.01.021
info:cnr-pdr/source/autori:Gonzalez-Teran B.; Pittman M.; Felix F.; Thomas R.; Richmond-Buccola D.; Huttenhain R.; Choudhary K.; Moroni E.; Costa M.W.; Huang Y.; Padmanabhan A.; Alexanian M.; Lee C.Y.; Maven B.E.J.; Samse-Knapp K.; Morton S.U.; McGregor M.; Gifford C.A.; Seidman J.G.; Seidman C.E.; Gelb B.D.; Colombo G.; Conklin B.R.; Black B.L.; Bruneau B.G.; Krogan N.J.; Pollard K.S.; Srivastava D./titolo:Transcription factor protein interactomes reveal genetic determinants in heart disease/doi:10.1016%2Fj.cell.2022.01.021/rivista:Cell (Cambridge)/anno:2022/pagina_da:794/pagina_a:814.e30/intervallo_pagine:794–814.e30/volume:185

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcdf4435eb5987a378294012ffb20d0
https://escholarship.org/uc/item/00m1b8f0

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

Autor: Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Bruce D. Gelb, Elisabetta Moroni, Giorgio Colombo, Casey A. Gifford, Nevan J. Krogan, Deepak Srivastava, Kaitlen Samse-Knapp, Brian L. Black, Bonnie Cole, Franco Felix, Michael Alexanian, Bárbara González-Terán, Benoit G. Bruneau, Katherine S. Pollard, Maureen Pittman, Michael McGregor, Bruce R. Conklin, Krishna Choudhary

SUMMARYCongenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains a challenge despite large-scale genomic sequencing efforts. We hypothesized that genetic determinants for CHDs may lie in protein in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08cb514f7b4ca318bf306b2c3b24e86a
https://doi.org/10.1101/2021.01.05.423837

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Autor: Parisha P. Shah, Arun Padmanabhan, Franco Felix, Ricardo Linares-Saldana, Rajan Jain, Andrew J. Connolly, Qiming Duan, Michael Alexanian, Qiaohong Wang, Wonho Kim, Saptarsi M. Haldar, Austin Hsu, Gaia Andreoletti, Yu Huang, Sarah A. B. Winchester, Juan A. Perez-Bermejo, Bárbara González-Terán, Li Li, Deepak Srivastava

Publikováno v: Circulation, vol 142, iss 24

Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2f901da1e37ad46432723db6cc69f5
https://escholarship.org/uc/item/9592f6t2

A transcriptional switch governs fibroblast activation in heart disease

Autor: Rajan Jain, Ricardo Linares-Saldana, Rudi Micheletti, Pawel F. Przytycki, Arun Padmanabhan, Katherine S. Pollard, Sanjeev S. Ranade, Lin Ye, Li Li, Ana C. Silva, Bárbara González-Terán, Angelo Pelonero, Qiming Duan, Saptarsi M. Haldar, Nandhini Sadagopan, Joshua G. Travers, Michael Alexanian, Deepak Srivastava, Clara Youngna Lee, Franco Felix, Michael G. Rosenfeld, Gaia Andreoletti, Timothy A. McKinsey, Yu Huang, Casey A. Gifford

Publikováno v: Signal Transduction and Targeted Therapy
Nature
Nature, vol 595, iss 7867

In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b4799c8e327071d007123e085da0e
https://pubmed.ncbi.nlm.nih.gov/34952898

Maten a Darwin

Autor: Franco Félix

Maten a Darwin es una desmesurada selva narrativa, desquiciadamente minuciosa y total. Los descendientes de Charles Darwin están obsesionados con encontrar la fórmula de la vida eterna. Sin embargo, y paradójicamente, al ser el resultado de una un