Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Franco FO"'
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Andrea Mattarei, Stefano Comai, Franco Folli, Marco Pappagallo, Clotilde Guidetti, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 341-352 (2024)
Abstract Background and Objectives Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker that showed a rapid and sustained adjunctive antidepressant effec
Externí odkaz:
https://doaj.org/article/54082aea68a3451ba1202c9e94b535ab
Autor:
Jingyu An, Roma Kurilov, Teresa Peccerella, Frank Bergmann, Mouad Edderkaoui, Adrian Lim, Xu Zhou, Katrin Pfütze, Angela Schulz, Stephan Wolf, Kai Hu, Christoph Springfeld, Sadaf S. Mughal, Lenart Zezlina, Franco Fortunato, Georg Beyer, Julia Mayerle, Susanne Roth, Johannes Hulkkonen, Daniela Merz, Shigenori Ei, Arianeb Mehrabi, Martin Loos, Mohammed Al-Saeedi, Christoph W. Michalski, Markus W. Büchler, Thilo Hackert, Benedikt Brors, Stephen J. Pandol, Peter Bailey, John P. Neoptolemos
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102109- (2024)
Background: Despite some recent advances, pancreatic ductal adenocarcinoma (PDAC) remains a growing oncological challenge. New drugs capable of targeting more than one oncogenic pathway may be one way to improve patient outcomes. This study character
Externí odkaz:
https://doaj.org/article/df5a8e4d1fe7474090e2aa259e799323
Autor:
Filippo Liviero, Maria Luisa Scapellato, Anna Volpin, Monica Battistella, Laura Fabris, Laura Brischigliaro, Franco Folino, Angelo Moretto, Paola Mason, Sofia Pavanello
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionPrior investigations into post-COVID dysautonomia often lacked control groups or compared affected individuals solely to healthy volunteers. In addition, no data on the follow-up of patients with SARS-CoV-2-related autonomic imbalance are
Externí odkaz:
https://doaj.org/article/7b46e8c68b844a209ee27ae6853eb049
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 1, Pp 51-68 (2023)
Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blo
Externí odkaz:
https://doaj.org/article/9a07ec79820f4842b2bf83183c3444df
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Autor:
Maria Elena Lunati, Vincenzo Cimino, Davide Bernasconi, Alessandra Gandolfi, Paola Silvia Morpurgo, Camilla Tinari, Elisa Lazzaroni, Laura Baruffaldi, Milena Muratori, Laura Montefusco, Ida Pastore, Antonio Rossi, Ivano Giuseppe Franzetti, Fabrizio Muratori, Roberto Manfrini, Olga Eugenia Disoteo, Rosa Terranova, Paolo Desenzani, Angela Girelli, Renata Ghelardi, Francesca D’Addio, Moufida Ben Nasr, Cesare Berra, Franco Folli, Loredana Bucciarelli, Paolo Fiorina
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107040- (2024)
Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor and semaglutide, a glucagon-like peptide 1 receptor agonist, have both demonstrated efficacy in glycemic control, reducing blood pressure, body weight, risk of renal and heart failure in type
Externí odkaz:
https://doaj.org/article/896fc8acef4049c186f0bd9af04fa581
Autor:
Sara Piccini, Giuseppe Favacchio, Cristina Panico, Emanuela Morenghi, Franco Folli, Gherardo Mazziotti, Andrea Gerardo Lania, Marco Mirani
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in cardiovascular outcome trials in type 2 diabetes mellitus. However, the most convincing evidence was obtained in subjects with established
Externí odkaz:
https://doaj.org/article/90dfb7662cc049948061b82984ee197b
Autor:
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert c
Externí odkaz:
https://doaj.org/article/af8fabe8ee0d48f4ab00370a37dd858f
Autor:
de Almeida, RF, Silveira, CH, Mikhael, JER, Franco, FO, Ribeiro, BT, Ferreira, A de Siqueira, de Sa Mendonca, E, Wendling, B
Publikováno v:
African Journal of Biotechnology; Vol 13, No 33 (2014)
The decomposition/mineralization of organic material from crop residues constitutes an important nutrient reservoir for plants. This process produces CO2 and is influenced by biophysical and environmental conditions such as temperature, oxygen availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=78975075580c::5226e1676c83630d50c60a061623e514
https://www.ajol.info/index.php/ajb/article/view/122006
https://www.ajol.info/index.php/ajb/article/view/122006
Autor:
Marco Anzidei, Daniele Trippanera, Alessandro Bosman, Franco Foresta Martin, Fawzi Doumaz, Antonio Vecchio, Enrico Serpelloni, Tommaso Alberti, Sante Francesco Rende, Michele Greco
Publikováno v:
Journal of Marine Science and Engineering, Vol 11, Iss 10, p 2013 (2023)
The island of Ustica (Italy) is constantly exposed to the effects of sea-level rise, which is threatening its coastal zone. With the aim of assessing the sea levels that are anticipated by 2150 CE under the climatic projections shown in the AR6 repor
Externí odkaz:
https://doaj.org/article/c6bfb6f7df29441387ff4afe1d1371d5