Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Franco Conti"'
Autor:
Michele Pistacchi, Andrea Pezzato, Roberta Rudà, Manuela Gioulis, Franco Contin, Federica Fragiacomo, Sandro Zambito Marsala
Publikováno v:
Folia Neuropathologica, Vol 61, Iss 3, Pp 225-234 (2023)
Spontaneous intracranial hypotension (SIH) is a condition of negative intracranial pressure resulting from cerebrospinal fluid (CSF) leakage from the dural sac and is a well-known cause of orthostatic headache. Diagnosis and management can be difficu
Externí odkaz:
https://doaj.org/article/51d19133235a4491b7c155b4517eb5de
Publikováno v:
Biophysical Journal. 86:191-209
Kappa-conotoxin PVIIA (kappa-PVIIA), a 27-amino acid peptide identified from the venom of Conus purpurascens, inhibits the Shaker K+ channel by blocking its outer pore. The toxin appears as a gating modifier because its binding affinity decreases wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74db832780a4c199b057217d0d2e7a18
https://doi.org/10.1016/s0006-3495(04)74096-5
https://doi.org/10.1016/s0006-3495(04)74096-5
Tonic and Phasic Guanidinium Toxin-Block of Skeletal Muscle Na Channels Expressed in Mammalian Cells
Publikováno v:
Biophysical Journal. 84:2999-3006
The blockage of skeletal muscle sodium channels by tetrodotoxin (TTX) and saxitoxin (STX) have been studied in CHO cells permanently expressing rat Nav1.4 channels. Tonic and use-dependent blockage were analyzed in the framework of the ion-trapped mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee17fa0255aa405fdbbd78622e224b79
https://doi.org/10.1016/s0006-3495(03)70026-5
https://doi.org/10.1016/s0006-3495(03)70026-5
Sodium channel heterologous expression in mammalian cells and the role of the endogenous β1-subunits
Publikováno v:
Neuroscience Letters. 336:175-179
Sodium currents in cell lines transfected with the sole alpha-subunit, or constitutively expressing sodium channels, have an inactivation that is always prevalently mono-exponential. Differently, expression of alpha-subunit in Xenopus oocytes exerts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b38b7d645808c6406b13c32bf50b4a1
https://doi.org/10.1016/s0304-3940(02)01284-3
https://doi.org/10.1016/s0304-3940(02)01284-3
Autor:
Antonella Liantonio, Sonia Traverso, Franco Conti, Patrizia Guida, Alessio Accardi, Michael Pusch, Diana Conte Camerino
Publikováno v:
Molecular Membrane Biology. 19:285-292
CLC proteins are a nine-member gene family of Cl- channels that have diverse roles in the plasma membrane and in intracellular organelles. The recent structure determination of bacterial CLC homologues by Dutzler et al. was a breakthrough for the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc512551782f046a173309f74c6b5bd
https://doi.org/10.1080/09687680210166938
https://doi.org/10.1080/09687680210166938
Autor:
Franco Conti, Oscar Moran
Publikováno v:
Biochemical and Biophysical Research Communications. 282:55-59
The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac384336f2b4c034f8fb4c5794ce135a
https://doi.org/10.1006/bbrc.2001.4502
https://doi.org/10.1006/bbrc.2001.4502
Autor:
Antonella Liantonio, Michael Pusch, Franco Conti, Diana Conte Camerino, Annamaria De Luca, Alessio Accardi, Loretta Ferrera
Publikováno v:
The Journal of General Physiology
We investigated in detail the mechanism of inhibition by the S(−) enantiomer of 2-(p-chlorophenoxy)butyric acid (CPB) of the Torpedo Cl− channel, ClC-0. The substance has been previously shown to inhibit the homologous skeletal muscle channel, CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6612b5e82be66e497a96ab8d5c3d71
http://europepmc.org/articles/PMC2233749
http://europepmc.org/articles/PMC2233749
Publikováno v:
Biochemical and Biophysical Research Communications. 275:839-844
Several observations suggest an interaction of the sodium channel alpha-subunit with the cytoskeletal structures. However, there is a wide variability in the results of experiments of heterologous expression in Xenopus oocytes and studies on mammalia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314a088c3eb679902e2dc70dcb8883a8
https://doi.org/10.1006/bbrc.2000.3398
https://doi.org/10.1006/bbrc.2000.3398
Publikováno v:
The Journal of General Physiology
κ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5548e292ab29829af4b550e77ff4bdfd
https://doi.org/10.1085/jgp.114.1.125
https://doi.org/10.1085/jgp.114.1.125
Publikováno v:
Journal of Bioenergetics and Biomembranes. 31:591-608
Three groups of mutations of the α subunit of the rat skeletal muscle sodium channel (rSkM1),homologous to mutations linked to human muscle hereditary diseases, have been studied byheterologous expression in frog oocytes: S798F, G1299E, G1299V, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46d055b1dedf85375546326f547c114c
https://doi.org/10.1023/a:1005473129183
https://doi.org/10.1023/a:1005473129183