Fibrotic Changes and Endothelial-to-Mesenchymal Transition Promoted by VEGFR2 Antagonism Alter the Therapeutic Effects of VEGFA Pathway Blockage in a Mouse Model of Choroidal Neovascularization

Autor: Franco Aparecido Rossato, Yu Su, Ashley Mackey, Yin Shan Eric Ng

Publikováno v: Cells, Vol 9, Iss 9, p 2057 (2020)

Many patients with wet age-related macular degeneration do not respond well to anti- vascular endothelial growth factor A (VEGFA) therapy for choroidal neovascularization (CNV), and the efficacy of anti-VEGFA decreases over time. We investigated the

Externí odkaz: https://doaj.org/article/ba750e905f7548e9bf187e5aa0a7d74f

Cytotoxicity of the coagulant Moringa oleifera lectin (cMoL) to B16-F10 melanoma cells

Autor: Thiago Henrique Napoleão, Rute Alves Pereira e Costa, Patrícia Maria Guedes Paiva, Luciana A. Luz, Franco Aparecido Rossato, Luana Cassandra Breitenbach Barroso Coelho

Publikováno v: Toxicology in Vitro. 44:94-99

Moringa oleifera seeds are used in alternative medicine to treat inflammation, tumors and bacterial and protozoan infections, for example. The seeds contain lectins, which are carbohydrate-binding proteins with several biological properties including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cde64030e96a1656e6e95219da8c12b
https://doi.org/10.1016/j.tiv.2017.06.019

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

Autor: Felipe Osório-Costa, Marília M. Dias, Anibal E. Vercesi, Mario J.A. Saad, Eduardo R. Ropelle, José B.C. Carvalheira, Franco Aparecido Rossato, Guilherme Z. Rocha

Publikováno v: Clinical Cancer Research. 17:3993-4005

Purpose: Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated protein kinase (AMPK) and reduction of mTOR signaling, have become noteworthy. Chemotherapy produces genotoxic stress and indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95788e2c51ca710321436745b4e7a26
https://doi.org/10.1158/1078-0432.ccr-10-2243

Endocytosis of tight junctions caveolin nitrosylation dependent is improved by cocoa via opioid receptor on RPE cells in diabetic conditions

Autor: Mariana Aparecida Brunini Rosales, Diego Andreazzi Duarte, Franco Aparecido Rossato, José B. Lopes de Faria, Jacqueline M. Lopes de Faria, Kamila C. Silva

Publikováno v: Investigative ophthalmologyvisual science. 55(9)

PURPOSE Retinal pigment epithelium cells, along with tight junction (TJ) proteins, constitute the outer blood retinal barrier (BRB). Contradictory findings suggest a role for the outer BRB in the pathogenesis of diabetic retinopathy (DR). The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd9f053d1c8750e52998f9cbdd4a654
https://pubmed.ncbi.nlm.nih.gov/25190662

Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration

Autor: Franco Aparecido Rossato, Roger F. Castilho, Luciane C. Alberici, Rose Mara Ortega, Paolo G. La Guardia, Rodrigo Ramos Catharino, Anibal E. Vercesi, Rute Alves Pereira e Costa, Edgard Graner, Karina G. Zecchin

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e101060 (2014)
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0652824fcef0e51351d946686db9ac6a
http://europepmc.org/articles/PMC4071076?pdf=render